Oral cancer awareness among aged patients with chronic oral mucosal diseases in Russian Federation

Гилева, О. С.; Libik, T. V.; Daurova, Fatima; Mudrova, O A; Redinova, Tatiana

doi:10.1051/bioconf/20202201027

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…The early diagnosis and management of OPMD represent a unique opportunity to develop strategies that will prevent malignant transformation, in addition to the existing such as avoiding tobacco/alcohol exposures. A multiple approach integrating health education, tobacco/alcohol decrease, and early detection is needed to intercept OPMD to OCSCC transformation [4,6]. Improving awareness of patients and caregivers and better screening of these lesions at the earlier stages are the key measures to slow down oral cancers occurrence.…”

Section: Introductionmentioning

confidence: 99%

The 4P: Preventing Preneoplasia through Patients Partnership

Virgone

Badreh

2021

Cancers

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The early diagnosis and management of oral potentially malignant disorders (OPMD) represent a unique opportunity to develop strategies that will prevent malignant transformation. Despite a high prevalence, awareness remains low, patient outcomes poor, and quality of life highly affected. How can patient advocacy groups (PAGs) bring more awareness to preneoplasia preceding oral cancers and help patients after the identification of a suspicious oral leukoplakia presented as white patches in the mouth? PAGs are today involved with awareness campaigns, lobbying, and education of both health care systems as well as the survivor and the newly diagnosed. PAGs are a link between the clinician and the patient, making sure that the medical terminology used is explained in layman language and that psychological support is available during and after treatment. This review outlines the actions that could be deployed by PAGs to successfully complete OPMD prevention challenge. The added value of researchers and patient representatives working together is the increased awareness of the problem. To know at which angle to best approach it for encouraging early diagnosis, improved education of disease signs and symptoms will condition effective prevention from the beginning.

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Section: Introductionmentioning

confidence: 99%

The 4P: Preventing Preneoplasia through Patients Partnership

Virgone

Badreh

2021

Cancers

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Key dental problems of an elderly patient: interdisciplinary educational platform

Гилева

Ризаев

Бекжанова

et al. 2023

Perm Medical Journal

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Objective. To analyze the key dental problems of an elderly patient, to justify interdisciplinary approaches to diagnostics, treatment and prevention of age-associated diseases of the oral cavity and maxillofacial region. Materials and methods. The materials of the international interdisciplinary discourse on the problem of Elderly patient: panorama of the challenges of modern dentistry are summarized. The most urgent and not completely solved problems of modern gerodontology are highlighted based on the analysis of new and updated specialized scientific information, as well as generalization of the experience of own clinical observations in the provision of dental (medical) care to the elderly. Results. Updated definitions of the aging process of the body are presented, its main patterns are revealed. The significance of determining the aging profile by organismal, molecular, cellular and genetic indicators is revealed. Promising laboratory parameters for assessing biological age / aging rate based on the analysis of oral fluid and cytological material of the oral epithelium are presented. The importance of intersystem interactions between a dentist and internists (therapists, cardiologists, dermatologists, neurologists, etc.) for the provision of effective and safe dental care to the elderly has been determined. New data on the nature of age-related changes in the hard dental tissues, periodontium, oral mucosa, oral oncopathology, as well as features of the manifestation, diagnosis and treatment of major age-associated oral diseases are disclosed. Conclusions. The peculiarities of dental treatment of elderly patients are regulated taking into account the necessary volumes, time regulations, ergonomics, sanitary and antiepidemic regime, methods of conducting, used therapeutic agents and materials. The significance of the development of new interdisciplinary educational platforms on the problems of gerodontology for dentists of various profiles is determined.

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Risk assessment of oral leukoplakia malignant transformation based on the ubiquitin-proteasome system indicators

Mikhalev,

Baydik,

Kondakova

et al. 2023

Parodontologiâ

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Relevance. The ubiquitin-proteasome system controls the activity and stability of various cellular proteins that affect cellular homeostasis by the regulation of signalling cascades. The system activity is associated with the onset and progression of oral squamous cell carcinoma, as the system participates in the specific proteolysis of most intracellular proteins involved in cancer pathogenesis.Material and methods. The study included 61 patients (28 men and 33 women) aged 21 to 75 y.o. The study determined chymotrypsin-like (CTL) and caspase-like (CL) activities of circulating and intracellular proteasomes in blood serum and biopsy specimens taken from the oral mucosa by hydrolysis of the corresponding fluorogenic oligopeptide on a «Cytation1» multi-mode microplate reader-imager at an excitation wavelength of 360 nm and an emission of 460 nm, the specific activity of the proteasomes was expressed in units of activity.Results. The value of the specific chymotrypsin-like activity of circulating proteasomes in non-homogeneous leukoplakia and oral squamous cell carcinoma was 1.76 (p < 0.001) times and 2.27 (p < 0.001) times higher relative to the comparison group. Pairwise comparison of signs showed a statistically significant difference in chymotrypsinlike activity between the groups of non-homogeneous and homogeneous leukoplakia (p < 0.001), non-homogeneous leukoplakia and oral squamous cell carcinoma (p = 0.04). The values of specific chymotrypsin-like and caspase-like activities of intracellular proteasomes in biopsy specimens taken from the pathological focus in the groups of homogeneous, non-homogeneous leukoplakia and squamous cell carcinoma of the oral cavity were 1.6, 2.38, 3 (p = 0.002, p = 0.004, p = 0.03) and 1.5, 2.8 and 3.3 (p = 0.003, p = 0.012, p < 0.001) times higher compared to the control group.Conclusion. The proposed logit model for risk assessment of oral leukoplakia malignant transformation, based on the indicators of the ubiquitin-proteasome system, can improve the quality of diagnosis.

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Oral cancer awareness among aged patients with chronic oral mucosal diseases in Russian Federation

Cited by 3 publications

References 30 publications

The 4P: Preventing Preneoplasia through Patients Partnership

The 4P: Preventing Preneoplasia through Patients Partnership

Key dental problems of an elderly patient: interdisciplinary educational platform

Risk assessment of oral leukoplakia malignant transformation based on the ubiquitin-proteasome system indicators

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