Oral cancer awareness for the general practitioner: new approaches to patient care

Farah, CS; McCullough, Michael

doi:10.1111/j.1834-7819.2007.00002.x

Cited by 47 publications

(47 citation statements)

References 62 publications

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“…The most common oral diseases classified as OPMD are leukoplakia, oral lichen planus, verrucous proliferative leukoplakia and erythroplakia, manifesting as white-, red-, white-red patches or spots (6,14,15).…”

Section: Discussionmentioning

confidence: 99%

Direct Visualization of Oral-Cavity Tissue Fluorescence as Novel Aid for Early Oral Cancer Diagnosis and Potentially Malignant Disorders Monitoring

Paderni

Compilato

Nardi

et al. 2011

Int J Immunopathol Pharmacol

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Direct visualization of the oral tissue autofluorescence has been recently reviewed in several studies as a possible adjunctive tool for early recognition and diagnosis of potentially malignant and malignant oral disorders. The aims of this study were to assess: a) the value of a simple handheld device for tissue auto-fluorescence visualization of potentially malignant oral lesions; and b) the sensitivity, specificity and diagnostic accuracy of tested device, using histological examination as the gold standard. 175 consecutive patients, with at least one clinical oral lesion, were enrolled in the study. Clinical conventional inspections were performed for each patient by two blind operators. Then, oral biopsy and histological examination were performed. Pathologist was blind with respect to the autofluorescence results. The 175 histological assessments revealed no dysplasia, mild dysplasia, moderate/severe dysplasia and OSCC, in the 67.4%, 8.6%, 8%,16% of cases, respectively. Oral lesions diagnosed as OSCC were found as positive under fluorescent light in the 96.4% of cases. Statistically significant correlation was observed between oral dysplastic lesions and the loss of tissue fluorescence (p-value=O.OOI). Low sensitivity values (60% and 71%) were recorded about the ability of the device in differentiating mild dysplasia vs, lack of dysplasia and moderate/severe dysplasia vs absence of dysplasia, respectively. The device tested in our study was found to not replace the histopathology procedure. However, we assessed its usefulness for oral tissue examination, especially within an oral medicine secondary care facility, before performing a biopsy and in monitoring oral lesions.

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Section: Discussionmentioning

confidence: 99%

Direct Visualization of Oral-Cavity Tissue Fluorescence as Novel Aid for Early Oral Cancer Diagnosis and Potentially Malignant Disorders Monitoring

Paderni

Compilato

Nardi

et al. 2011

Int J Immunopathol Pharmacol

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“…There are currently a number of devices available commercially and readers are referred to a recent excellent perspective review of these. 3 It is also very significant that there is a current NHMRC-funded project jointly between the universities of Melbourne and Queensland examining just these issues.…”

mentioning

confidence: 99%

Screening programmes for the early detection and prevention of oral cancer

Kujan¹,

Glenny²,

Oliver³

et al. 2009

Australian Dental Journal

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Background: Screening programmes for major cancers, such as breast and cervical cancer have effectively decreased the mortality rate and helped to reduce the incidence of these cancers. Although oral cancer is a global health problem with increasing incidence and mortality rates, no national population-based screening programmes for oral cancer have been implemented. To date there is debate on whether to employ screening methods for oral cancer in the daily routine work of health providers. Objectives: To assess the effectiveness of current screening methods in decreasing oral cancer mortality. Search strategy: Electronic databases (MEDLINE, CANCERLIT, EMBASE (1966 to July 2005 and CENTRAL (The Cochrane Library 2005, Issue 3), bibliographies, handsearching of specific journals and contact authors were used to identify published and unpublished data. Selection criteria: Randomized controlled trials of screening for oral cancer or precursor oral lesions using visual examination, toluidine blue, fluorescence imaging or brush biopsy. Data collection and analysis: The search found 112 citations and these have been reviewed. One randomized controlled trial of screening strategies for oral

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“…52 -54 Public awareness of oral cancer seems alarmingly low, as demonstrated by Horowitz et al, 55 who found that fewer than 25% of subjects could name alcohol or tobacco as risk factors. 5 Use of a cancer information leaflet had a significant effect in raising the long-term level of knowledge of oral cancer in the general public and also had a secondary effect on disease awareness in the locale. 56 Lack of knowledge is only part of the problem, as a comparison of studies by McLeod et al 57 and Schnetler 58 provides evidence to suggest that campaigns to raise public awareness have made little T Baykul, HH Yilmaz, Ü Aydin et al…”

Section: Causes Of Delaymentioning

confidence: 99%

“…2,3 Survival rates for oral cancer are very poor, at approximately 50% overall, and have not improved markedly in the last few decades despite advances in therapeutic interventions. 4,5 It is now well established that early diagnosis of oral malignancies is an effective way of improving the clinical outcome for patients. 5 Detecting oral cancer at an early stage, when lesions are small or localized, is believed to be the most effective means to reduce death, morbidity and disfigurement from this disease.…”

Section: Introductionmentioning

confidence: 99%