Oral cancer detection and diagnosis: A promising future with quantum dots

Venkatachalam, Vijayaraj; Shanmugamprema, Deepankumar; Shellaiah, Muthaiah; Panchu, Sandeep Eswaran

doi:10.1016/j.pdpdt.2024.104251

Photodiagnosis and Photodynamic Therapy

2024

DOI: 10.1016/j.pdpdt.2024.104251

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Oral cancer detection and diagnosis: A promising future with quantum dots

Vijayaraj Venkatachalam,

Deepankumar Shanmugamprema,

Muthaiah Shellaiah

et al.

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2024

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Cited by 3 publications

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Quantum dots in dental applications: paving the way for a promising future

Venkatachalam

2024

Eur Arch Paediatr Dent

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Quantum dots in dental applications: paving the way for a promising future

Venkatachalam

2024

Eur Arch Paediatr Dent

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Luminescent probes/conjugates derived from quantum dots, nanoparticles, and nanoclusters for cyanide (CN⁻) detection

Shellaiah,

Manikandan,

Sun

et al. 2024

Nano Ex.

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Advancing the development of the luminescent nanoprobes and conjugates toward the toxic analyte quantification plays a crucial role in environmental remedy. Cyanide ions (CN-) play vital role in many industries, such as electroplating, mining, textiles, metallurgy, etc. The highly toxic CN- may be discharged into the environment. The presence of CN- in aquatic environment at micromolar level could lead to fatal issue in humans and living beings, which requires scrutiny to maintain the ecosystem. Thus, diverse probes, such as organic fluorophores, noble metal nanoparticles/clusters (NPs/NCs), carbon/graphene quantum dots (CQDs/GQDs), cadmium telluride/selenide quantum dots (CdTe QDs/CdSe QDs), cadmium/zinc/silver sulfide quantum dots (CdS QDs/ZnS QDs/ Ag2S QDs), etc., were proposed toward the quantification of CN- ions with real-time applications. Among them, the luminescent probes/conjugates derived from QDs, NPs, and NCs are unique and display astonishing selectivity and sensitivity to CN-. The observed luminescent responses can be attributed to agglomeration, inner filter effect (IFE), fluorescence resonance energy transfer (FRET), chemiluminescence resonance energy transfer (CRET), etc. Till now there is no review article reporting the applications of the luminescent probes/conjugates derived from QDs, NPs, and NCs for CN- quantification. In this review, the employment of these probes/conjugates for detecting CN- is illustrated with detailed underlying mechanisms and real-time applications. Furthermore, the design requirements, advantages, limitations, and directions of the luminescent probes/conjugates are delivered for future studies.

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Internal Audit of an Oral Pathology Laboratory: Perspectives on Finances and Operational Management

Ramalingam,

Ramani

et al. 2024

Cureus

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Background Internal audits are essential tools for enhancing the operational efficiency, quality, and effectiveness of healthcare departments. Audits enable the departments and laboratories to meet the changing needs of the healthcare environment by giving a detailed picture of the department's operations and highlighting areas for possible growth and development. Aims and objectives This study focuses on the biopsies received in the Oral Pathology Department at Saveetha Dental College, aiming to evaluate biopsy trends, financial performance, and resource utilization over one year. Materials and methods The oral pathology department audit covered the period from 1st April 2023 to 31st March 2024. The institutional human ethical committee and scientific review board approved the retrospective audit. It involved a comprehensive analysis of biopsy data, financial records, and material usage. Data on different biopsy types (excisional, incisional, frozen sections), immunohistochemistry, cytology, and special stains were collected and analyzed across four quarters. Financial performance was assessed by comparing total income and expenses, while resource utilization was examined through the use of histopathological blocks and other consumables. Statistical analysis (chi-square) was performed using IBM SPSS Statistics for Windows, Version 23 (Released 2015; IBM Corp., Armonk, New York, United States). A P-value less than 0.05 was considered statistically significant. Results We received 1100 cases during the study period. Excisional biopsies were the most common, with 474 (43.09%) cases, followed by incisional biopsies with a total of 432 (39.27%). Out of total cases of 1100, the second quarter (July-September 2023) had the highest case volume of 305 (27.72%), while the third quarter (October-December 2023) recorded the lowest of 250 (22.72%) cases. A financial audit revealed an annual deficit of ₹1,03,321 primarily due to higher expenses towards laboratory reagents. The overall expense incurred per case was ₹448.5. Tissue blocks cost ₹85.23 per case (19.00%) of the average cost per case. The chi-square test analysis was insignificant among the different types of biopsies and the reagent consumption across the four quarters. Conclusion The audit identified critical areas for improvement in both clinical workload and financial management. High volumes of biopsies, but net financial deficits highlight the need for better cost management and resource utilization strategies to maintain sustainability without compromising diagnostic quality.

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Oral cancer detection and diagnosis: A promising future with quantum dots

Cited by 3 publications

References 13 publications

Quantum dots in dental applications: paving the way for a promising future

Quantum dots in dental applications: paving the way for a promising future

Luminescent probes/conjugates derived from quantum dots, nanoparticles, and nanoclusters for cyanide (CN⁻) detection

Internal Audit of an Oral Pathology Laboratory: Perspectives on Finances and Operational Management

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Oral cancer detection and diagnosis: A promising future with quantum dots

Cited by 3 publications

References 13 publications

Quantum dots in dental applications: paving the way for a promising future

Quantum dots in dental applications: paving the way for a promising future

Luminescent probes/conjugates derived from quantum dots, nanoparticles, and nanoclusters for cyanide (CN−) detection

Internal Audit of an Oral Pathology Laboratory: Perspectives on Finances and Operational Management

Contact Info

Product

Resources

About

Luminescent probes/conjugates derived from quantum dots, nanoparticles, and nanoclusters for cyanide (CN⁻) detection