Oral cancer in Southern India: the influence of body size, diet, infections and sexual practices

Rajkumar, Thangarajan; Hanumanthaiah, Sridhar; Balaram, Prabha; Vaccarella, Salvatore; Gajalakshmi, Vendhan; Nandakumar, A.; Ramdas, K.; Jayshree, R. S.; Muñóz, Núbia; Herrero, Rolando; Franceschi, Silvia; Weiderpass, Elisabete

doi:10.1097/00008469-200304000-00007

Cited by 85 publications

(80 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…General characteristics of case-control and cohort studies are shown in Tables 1 and 2, respectively. Case-control studies were published between 1994 and 2014; three were conducted in Italy (13,19,22) , two each in Iran (10,15) , China (12,23) and Australia (14,29) , and one each in Poland (16) , Spain (11) , Czech Republic (17) , Brazil (18) , UK (20) , India (24) , Hawaii (25) , Mexico (26) , Sweden (27) and Uruguay (28) . One was a multinational study conducted in nine countries worldwide (Italy, Spain, Poland, Northern Ireland, India, Cuba, Canada, Australia and Sudan) (21) Cohort studies were published between 1998 and 2012; nine were conducted in the USA (30,31,(34)(35)(36)(37)39,40,45) and eight were conducted in Europe (32,33,38,(41)(42)(43)(44)46) .…”

Section: Literature Searchmentioning

confidence: 99%

Apple intake and cancer risk: a systematic review and meta-analysis of observational studies

Fabiani

Minelli

Rosignoli

2016

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Conflicting results on the association between fruit consumption and cancer risk have been reported. Little is known about the cancer preventive effects of different fruit types. The present meta-analysis investigates whether an association exists between apple intake and cancer risk. Design: Relevant observational studies were identified by literature search (PubMed, Web of Science and Embase). A random-effect model was used to estimate the cancer risk in different anatomical sites. Between-study heterogeneity and publication bias were assessed using adequate statistical tests. Results: Twenty case-control (three on lung, five on colorectal, five on breast, two on oesophageal, three on oral cavity, two on prostate and one each on pancreas, bladder, larynx, ovary, kidney and brain cancer) and twenty-one cohort (seven on lung, two on colorectal, three on breast and one each on oesophageal, pancreas, bladder, kidney, endometrial, head-neck, urothelial and stomach cancer) studies met the inclusion criteria. Comparing the highest v. lowest level of apple consumption, the reduction of lung cancer risk was statistically highly significant in both case-control (OR = 0·75; 95 % CI 0·63, 0·88; P = 0·001, I 2 = 0 %) and cohort studies (relative risk = 0·89; 95 % CI 0·84, 0·94; P < 0·001, I 2 = 53 %). Instead, in the case of colorectal (OR = 0·66; 95 % CI 0·54, 0·81; P < 0·001, I 2 = 55 %), breast (OR = 0·79; 95 % CI 0·73, 0·87; P < 0·001, I 2 = 1 %) and overall digestive tract (OR = 0·50; 95 % CI 0·36, 0·69; P < 0·001, I 2 = 90 %) cancers a significant preventive effect of apples was found only in case-control studies while prospective studies indicated no effect. No evidence of publication bias could be detected for colorectal, oral cavity, oesophageal and breast cancer. However, some confounding effects may be present and related to the consumption of other fruit which have not been considered as adjusting factors. Conclusions: The present meta-analysis indicates that consumption of apples is associated with a reduced risk of cancer in different anatomical sites. Keywords Cancer preventionApple intake Dietary Epidemiology Meta-analysis Cancer is a chronic degenerative disease causing major morbidity and mortality in Western countries. It has been estimated that in the year 2012, 14·1 million new cancer cases were diagnosed and 8·2 million cancer deaths were established (1) . The overall age-standardized cancer incidence rates vary three-to fivefold across different regions of the world (2) . These variations may be related to different modifiable risk and preventive factors among which diet may play a central role. It has been estimated that about one-third of all cancer could be avoidable by changes in eating habits (3) .Foods of plant origin have received particular interest over the years as potential cancer-preventive components of a healthy diet. Fruit and vegetables contain a myriad of bioactive phytochemicals that, through various molecular mechanisms, show chemopreventive properties in both in...

show abstract

Section: Literature Searchmentioning

confidence: 99%

Apple intake and cancer risk: a systematic review and meta-analysis of observational studies

Fabiani

Minelli

Rosignoli

2016

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…Most of the oral cancers in India are linked with diet, weight and other lifestyle factors including betal quid (paan) chewing (Tondon et al, 2000). Body mass index (BMI) has been inversely associated with oral cancer, and paan chewers with low BMI has a very high risk of oral cancer (Rajkumar et al, 2003). Sharma et al (2010) have observed variable incidence of oral cancer within one geographical location as per age, sex, site or habit.…”

Section: Cancer Mouthmentioning

confidence: 99%

Head and Neck Cancer: Global Burden and Regional Trends in India

Mishra

Meherotra²

2014

Asian Pacific Journal of Cancer Prevention

158

100

View full text Add to dashboard Cite

“…72,73 In Sweden, several large, population-based, case-control studies reported no association between intensity or duration of moist snuff use (pasteurized and low in TSNA) and oral cancer. 69,[74][75][76] In India, where smokeless tobacco is often mixed with other carcinogenic substances (betel, areca nut, and lime), very strong doseresponse relationships were observed with increased intensity and duration of smokeless tobacco use and risk of premalignant 77,78 and malignant 44,79,80 lesions of the oral cavity. These conflicting findings can be explained by type of smokeless tobacco use, variability in qualitative and quantitative measures of use, and the number of cases and their anatomic site distribution.…”

Section: Smokeless Tobaccomentioning

confidence: 99%

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

2007

View full text Add to dashboard Cite

Oral cancer incidence rates rose dramatically during the twentieth century in the United States and Europe, especially among individuals under the age of 60 years. Although influenced by age, sex, and country of origin, incidence trends were most strongly affected by elevated risk among individuals born after approximately 1915. This cohort effect was indicative of strong behavioral influences on oral cancer risk. In this article, associations between oral cancer risk and established behavioral risk factors including alcohol and tobacco use are reviewed. Additionally, possible associations between oral cancer risk and oral hygiene, diet, nutritional status, and sexual behavior as well as the influence of genetic factors on oral cancer risk are considered. Special emphasis is placed on evaluating possible risk differences in individuals above and below the age of 45 and in users and nonusers of alcohol and tobacco. Oral squamous cell carcinomas arise from several anatomic sites within the oral cavity and oropharynx, but most commonly from the oral, mobile tongue.1 In the 1980s, 2 cancer centers in the United States (U.S.) reported an increase in the proportion of incident oral tongue cancers diagnosed in men younger 40 years.2,3 Although absolute numbers had increased, these reports provided no real evidence of rising incidence. Shortly thereafter, however, a significant 2-fold increase in oral tongue cancer mortality rates between 1950 and 1982 was reported in the U.S. for men younger than 30 years. 4 This finding was corroborated by a study in Scotland. 5 Further analysis of the Scottish data revealed that the increase in incidence was not restricted to those younger than 40 but extended to all age groups less than 65 years of age born after 1920-a strong ''cohort effect.'' The cohort effect was indicated by a strong effect of year of birth on oral cancer incidence rates. A flurry of research on global changes in oral cancer incidence was stimulated by these reports.

show abstract

Oral cancer in Southern India: the influence of body size, diet, infections and sexual practices

Cited by 85 publications

References 24 publications

Apple intake and cancer risk: a systematic review and meta-analysis of observational studies

Apple intake and cancer risk: a systematic review and meta-analysis of observational studies

Head and Neck Cancer: Global Burden and Regional Trends in India

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

Contact Info

Product

Resources

About