Oral cancer in young adults: report of three cases and review of the literature

Oliver, Richard; Dearing, James W.; Hindle, I

doi:10.1038/sj.bdj.4800481

Cited by 45 publications

(37 citation statements)

References 20 publications

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“…Llewellyn et al analyzed risk factors for oral cancer in patients 45 and younger and showed a significantly elevated odds ratios for oral cancer in patients who smoked C21 years [20]. This points to the potential influence of additional etiologic factors-such as genetic susceptibility, immunodeficiency, or viral infection-may be at work [2,3,12,21,22]. Lingen et al studied the overexpression of p53 in individuals \40 years old with tongue cancer and no known risk factors [17].…”

Section: Discussionmentioning

confidence: 99%

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Müller

Pan

et al. 2008

Head and Neck Pathol

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Background Several recent reports suggest an increasing incidence of oral squamous cell carcinoma (OSCC) among young persons in many regions of the world-a trend which is particularly concerning given the overall stabilization or even decline in incidence rates for head and neck cancer in general. The aim of this study is to determine whether there has been an increase in the number of cases of OSCC diagnosed in patients \40 years old by our biopsy service from 1971 to 2006. Methods A retrospective review of all OSCC cases diagnosed from 1971 to 2006 by the Emory University Hospital Oral Pathology biopsy service was performed. A comparison of demographic information, frequency, location and histologic grade was made between these cases as a whole and those occurring in a subset of patients \40 years old. Statistical procedures included chi-square analyses. Results From 1971-2006, 1,919 cases of OSCC were diagnosed, and 95 (5.0%) occurred in patients \40 years old.

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Section: Discussionmentioning

confidence: 99%

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Müller

Pan

et al. 2008

Head and Neck Pathol

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“…Head and neck cancer represents 5-10% of cases in europe, where there is a rising incidence of oral cancer and associated mortality, especially among young populations (1). the most frequent oral cancers are oral squamous cell carcinomas (osccs) which are the most malignant tumours of the head and neck (2).…”

Section: Introductionmentioning

confidence: 99%

Methylation in oral cancer and pre-cancerous lesions (Review)

Bascones-Martinez

2011

Oncol Rep

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Abstract. there is considerable interest in the analysis of epigenetic alterations in cancer, including oral cancer and pre-cancerous lesions. these processes affect or inactivate the functions of genes without altering their structure or sequence. one example is the methylation of the promoter region of some genes involved in cell cycle control. Knowledge of methylation patterns is very important for understanding the expression of genes in normal and pathological situations. this review provides an update on research into this issue in oral cancer and pre-cancerous lesions. A greater understanding of this epigenetic alteration could not only assist the diagnosis and prognosis of oral cancer but could also open up novel therapeutic approaches. the presence of methylation in specific tumour suppressor genes could modify their function and alter cell cycle control, so the patients could have an increased risk of developing cancer and also a higher degree of malignancy. the most frequently and extensively studied methylated genes in oral premalignant lesions are p16, MGMT, RARβ 2 , E-cadherin and DAP-kinase.

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“…2 Talvez defeitos genéticos em pacientes fumantes possam ter um papel importante na etiologia do CCE oral. 24 A etiologia ainda se encontra incerta, mas tem se dado cada vez mais importância a uma predisposição genética. 24 Uma consideração futura no desenvolvimento do CCE de cabeça e pescoço em adultos jovens pode ser a predisposição genética aos carcinógenos ambientais, anormalidades cromossômicas, aumento da suscetibilidade a um dano cromossômico induzido por um mutagen ou reparo deficiente do DNA.…”

Section: Associação De Fatoresunclassified

“…24 A etiologia ainda se encontra incerta, mas tem se dado cada vez mais importância a uma predisposição genética. 24 Uma consideração futura no desenvolvimento do CCE de cabeça e pescoço em adultos jovens pode ser a predisposição genética aos carcinógenos ambientais, anormalidades cromossômicas, aumento da suscetibilidade a um dano cromossômico induzido por um mutagen ou reparo deficiente do DNA. 16 Outras causas são propostas para o CCE oral em pacientes jovens sem fatores de risco assim como imunossupressão, infecção viral, hereditariedade, xeroderma pigmentoso, ou exposição oral a polivinil clorado.…”

Section: Associação De Fatoresunclassified

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Carcinoma de células escamosas da cavidade oral em pacientes jovens e sua crescente incidência: revisão de literatura

Venturi¹,

Pamplona

Cardoso

2004

Rev. Bras. Otorrinolaringol.

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A proposta deste estudo é rever o carcinoma de células escamosas oral na população jovem. A literatura mostra um comportamento diferente neste tipo de doença, que parece ser mais agressivo. Existe uma forte relação entre alguns hábitos (tabaco e consumo de álcool) e o desenvolvimento do carcinoma de células escamosas (CCE) oral, mas nestes casos os pacientes normalmente não relatam hábitos considerados de risco. Existe um pequeno número de relatos de casos de CCE oral em pacientes com menos de 40 anos de idade, então é difícil de provar o aumento da incidência do CCE da cavidade oral como dito na literatura. Outros estudos são necessários para entendermos melhor esta entidade. A identificação das características desta população jovem se faz necessária, pois pode refletir problemas no controle do câncer e pode possibilitar o desenvolvimento de um programa de prevenção primária para o CCE oral em pacientes jovens.

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Oral cancer in young adults: report of three cases and review of the literature

Cited by 45 publications

References 20 publications

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Changing Trends in Oral Squamous Cell Carcinoma with Particular Reference to Young Patients: 1971–2006. The Emory University Experience

Methylation in oral cancer and pre-cancerous lesions (Review)

Carcinoma de células escamosas da cavidade oral em pacientes jovens e sua crescente incidência: revisão de literatura

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