Oral Cancer: Risk Factors and Molecular Pathogenesis

Ram, Hari; Sarkar, Jayanta; Kumar, Hemant; Konwar, Rituraj; Bhatt, M L B; Mohammad, Shadab

doi:10.1007/s12663-011-0195-z

Cited by 197 publications

(162 citation statements)

References 31 publications

(34 reference statements)

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“…Depending on the location of the cancer within the oral cavity, men are two to six times more likely to be affected than females, which largely owes to their higher intake of alcohol and tobacco [9]. Also, in our study, more men than women had potentially malignant disorders which needing BBs, which was expected.…”

Section: Discussionsupporting

confidence: 47%

Transepithelial Brush Biopsy – Oral CDx® – A Noninvasive Method for the Early Detection of Precancerous and Cancerous Lesions

Casparis

Borm

Tomic

et al. 2014

JCDR

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Section: Discussionsupporting

confidence: 47%

Transepithelial Brush Biopsy – Oral CDx® – A Noninvasive Method for the Early Detection of Precancerous and Cancerous Lesions

Casparis

Borm

Tomic

et al. 2014

JCDR

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“…23 OSCC carcinogenesis is a multistep process involving biomolecular changes, premalignant lesions, and invasive cancer. 7,24 When the biomolecular changes begin in tissue, it is possible that the earliest mutations cause only increased keratin formation without visible dysplasia. 3 It is necessary to detect these biomolecular changes at the earliest time to prevent progression of the disease.…”

Section: Resultsmentioning

confidence: 99%

The Evaluation of Ghrelin Expression In Oral Leukoplakia And Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Fikirli¹,

Özeç²,

Eğılmez³

et al. 2017

EÜ Dişhek Fak Derg

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ÖZET AMAÇ: Biobelirteçler normal dokuda, prekanseröz lezyonlarda ve kanserli dokuda farklı miktarlarda bulunabilen proteinler veya genlerdir, biobelirteçlerin değerlendirilmesi daha etkin bir şekilde malign transformasyon öngörüsü yapılmasını sağlayabilir. Bu çalışmanın amacı normal oral epitel, oral lökoplaki ve oral skuamoz hücreli karsinomada (OSHK) ghrelin seviyelerinin araştırılarak karşılaştırılmasıdır. YÖNTEM: Patoloji bölümü arşivinden elde edilen toplam 55 adet daha önce tanısı konulmuş normal oral mukoza (n = 15), oral lökoplaki (n = 18) ve OSHK (n = 22) bloklarından deparafinize edilerek elde edilen preparatlar özel antikorlar kullanılarak immünhistokimyasal olarak boyanmış ve ghrelin seviyeleri değerlendirilmiştir. İmmünhistokimyasal boyamada ghrelin mevcudiyeti mikroskop altında 100 hücre değerlendirilerek sayısallaştırılmıştır. Ghrelin pozitif hücrelerde kahverengi sitoplazmik boyama görülmüştür. BULGULAR: Normal oral mukozada hücrelerinin % 64'ünde, oral lökoplaki hücrelerinin % 66'sında ghrelin pozitif boyama görülürken, OSHK'da bu boyama yalnızca hücrelerin % 8'inde olmuştur. Diğer gruplar ile karşılaştırıldığı zaman OSHK grubunda ghrelin pozitif boyalı hücre miktarının istatistiksel olarak anlamlı şekilde az olduğu görülmüştür (P < 0.05). SONUÇ: Normal oral mukoza ve oral lökoplaki ile karşılaştırıldığı zaman OSHK grubunda ghrelin seviyesinin daha az olduğu tespit edilmiştir. Oral lökoplaki ve normal oral mukoza gruplarının ghrelinin seviyelerinin benzer olduğu belirlenmiştir. Oral karsinogenezis ile birlikte oluşan ghrelin seviyesinde ki değişikliklerin artmış malign potansiyelin belirlenmesinde bir biobelirteç olabileceği düşünülmektedir.

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“…The high rate of OC in France and Eastern Europe has historically been linked to the heavy consumption of alcohol and tobacco in these countries. [2] Cancer is a major public health problem in the United States and many other parts of the world. One in 4 deaths in the United States is due to cancer.…”

Section: Incidence and Occurrencementioning

confidence: 99%

Oral Cancer Screening in Dental Set Up

Saini¹

2015

Int J of Biomed & Adv Res

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Cancer is a major public health problem in the United States and many other parts of the world. One in 4 deaths in the United States is due to cancer. Oral cancer (OC) is the sixth most common cancer worldwide. Oral cancer can be divided into three clinic-pathological categories: carcinoma of the lip vermillion, carcinoma of the oral cavity proper, and carcinoma of the oropharynx. The chief predisposing factors are tobacco use, alcohol consumption, and persistent viral infections such as HPV 16. Oral cancer is particularly dangerous because in its early stages it may not be noticed by the patient, as it can frequently prosper without producing pain or symptoms they might readily recognize, and because it has a high risk of producing second, primary tumors. The incorporation of OralID in the first-line practice settings, such as dental offices and primary health care settings may be a boon to population for their regular check up for early detect ion of pre malignant lesions.

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Oral Cancer: Risk Factors and Molecular Pathogenesis

Abstract: Considering known risk factors, oral cancer appears to be to a certain extent, a preventable disease. Recent development of molecular picture of pathoprogression and molecular genetic tools opens the avenue for easier diagnosis, better prognostication and efficient therapeutic management.

Cited by 197 publications

References 31 publications

Transepithelial Brush Biopsy – Oral CDx® – A Noninvasive Method for the Early Detection of Precancerous and Cancerous Lesions

Transepithelial Brush Biopsy – Oral CDx® – A Noninvasive Method for the Early Detection of Precancerous and Cancerous Lesions

The Evaluation of Ghrelin Expression In Oral Leukoplakia And Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Oral Cancer Screening in Dental Set Up

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