Oral Candida isolates and fluconazole susceptibility patterns in older Mexican women

Benito‐Cruz, Beatriz; Aranda‐Romo, Saray; López-Esqueda, Francisco Javier; Rosa-García, Estela de la; Rosas-Hernández, Rebeca; Sánchez-Vargas, Luis Octavio

doi:10.1016/j.archger.2016.04.001

Cited by 17 publications

(19 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Voriconazole can be used as step-down treatment of C. glabrata or C. krusei infections (if susceptibility results suggest that they are active) or if additional mould coverage is required [2,3]. In the elderly, colonisation and infections with non-albicans species, including C. glabrata, has been shown to be increased [6,33,34]. In recent studies, the susceptibility to fluconazole and voriconazole of non-albicans species isolated from the elderly was approximately doubled when compared with the susceptibility of isolates obtained from younger patients [6,7,35].…”

Section: Azolesmentioning

confidence: 99%

Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board

et al. 2016

View full text Add to dashboard Cite

Candida infections in the elderly are an important and expanding clinical problem, with significantly higher mortality in this group than in younger patients. The increasing problem of invasive Candida infections may be related to higher prevalence of immunocompromised older people and the emergence of treatment resistance. Older people, especially the frail and critically ill, are at higher risk of medication-related harmful effects due to changes in pharmacokinetics and pharmacodynamics, which may be further complicated by organ dysfunction, diminished homeostatic control, co-morbidities and polypharmacy. Here, we review the available options for the treatment of Candida infections and provide insights into the challenges surrounding the optimal use of antifungal drugs in the elderly. Key PointsCandida infections are a growing problem in elderly patients, with significant mortality in this group.Treatment in the elderly requires careful consideration of benefit and harm in the selection of both the drug and dose regimen.Therapeutic drug monitoring can be recommended for selected antifungal agents.

show abstract

Section: Azolesmentioning

confidence: 99%

Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Voriconazole can be used as step-down treatment of C. glabrata or C. krusei infections (if susceptibility results suggest that they are active) or if additional mould coverage is required [ 2 , 3 ]. In the elderly, colonisation and infections with non- albicans species, including C. glabrata , has been shown to be increased [ 6 , 33 , 34 ]. In recent studies, the susceptibility to fluconazole and voriconazole of non- albicans species isolated from the elderly was approximately doubled when compared with the susceptibility of isolates obtained from younger patients [ 6 , 7 , 35 ].…”

Section: Antifungal Treatment In the Elderlymentioning

confidence: 99%

Invasive Candidiasis in the Elderly: Considerations for Drug Therapy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Over the last ten years, some studies have found an increase in the Non-Albicans Candida (NAC) recovery frequency in oral mucosa: from 10 % in 1996 [15] to 15.0% [16] in 2010, 15.4 % in 2011 [17], and 20.0% in 2017 [35] in the case of C. parapsilosis at the level of healthy subjects. Among the local and/or systemic factors associated with the higher distribution of NAC species in the oral cavity, we could mention the use of prosthetic devices; [64] being elderly [65], elderly with low body mass index [66]; being an oncological patient undergoing chemotherapy or radiotherapy…”

Section: Oral Mucosa As a Potential Source Of Candidemia By Candida Pmentioning

confidence: 99%

“…Reports have indicated that C. parapsilosis and C. dubliniensis are the Candida species most frequently detected in oral niches after C. albicans among immune competent subjects [16,17,35,65,72,73]. Nevertheless, the epidemiology and behavior of the C. parapsilosis complex given different conditions of the oral cavity are still unknown.…”

Section: Oral Mucosa As a Potential Source Of Candidemia By Candida Pmentioning

confidence: 99%

Oral mucosa as a potential source of candidemia by Candida parapsilosis sensu stricto, under pathological conditions

Ml¹,

Ac²,

Jg³

et al. 2018

SOJMID

View full text Add to dashboard Cite

Over the past 10 years, there have been increasingly frequent reports of colonization of niches in the oral cavity by Non-Candida Albicans Candida (NCAC) species. Among these species, Candida parapsilosis sensu stricto plays a major part both locally and systemically. Evidence shows that it may be the second most frequent yeast isolate, after Candida albicans, as commensal in the oral cavity and as pathogen in blood cultures of patients diagnosed with fungemia. Recent reports suggest that both its distribution and its virulence may be affected by environmental conditions and may increase in situations of oral dysbiosis. Based on this background, we hypothesize that oral mucosa in pathological condition may be a source of candidemia by Candida parapsilosis sensu stricto, when promoted by the conditions in the host. We reviewed the scientific databases in search of evidence which may support such hypothesis.

show abstract

Oral Candida isolates and fluconazole susceptibility patterns in older Mexican women

Cited by 17 publications

References 33 publications

Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board

Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board

Invasive Candidiasis in the Elderly: Considerations for Drug Therapy

Oral mucosa as a potential source of candidemia by Candida parapsilosis sensu stricto, under pathological conditions

Contact Info

Product

Resources

About