Oral Candidal Load and Oral Health Status in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Case-Cohort Study

Khijmatgar, Shahnawaz; Belur, Giridhar; Venkataram, Rajesh; Karobari, Mohmed Isaqali; Marya, Anand; Shetty, Veena; Chowdhury, Avidyuti; Gootveld, Martin; Lynch, Edward; Shetty, Sunena; Shenoy, Shilpa; K, None Chaithra; Chowdhury, Chitta Ranjan

doi:10.1155/2021/5548746

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Most previous studies have focused on one or two indicators, such as periodontitis or the number of permanent teeth. 9 11 21 33 34 Additionally, Gaeckle and colleagues 35 recently showed that compared with healthy controls, participants with COPD had fewer teeth, a trend of a higher plaque index, and worse oral health-related quality of life. However, the study was limited by its small sample size.…”

Section: Discussionmentioning

confidence: 99%

Association Between Oral Health and Airflow Limitation: Analysis Using a Nationwide Survey in Korea

Kim

et al. 2023

J Korean Med Sci

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Background Although poor oral health is a common comorbidity in individuals with airflow limitation (AFL), few studies have comprehensively evaluated this association. Furthermore, the association between oral health and the severity of AFL has not been well elucidated. Methods Using a population-based nationwide survey, we classified individuals according to the presence or absence of AFL defined as pre-bronchodilator forced expiratory volume in 1 second/forced vital capacity < 0.7. Using multivariable logistic regression analyses, we evaluated the association between AFL severity and the number of remaining teeth; the presence of periodontitis; the Decayed, Missing, and Filled Teeth (DMFT) index; and denture wearing. Results Among the 31,839 participants, 14% had AFL. Compared with the control group, the AFL group had a higher proportion of periodontitis (88.8% vs. 79.4%), complete denture (6.2% vs. 1.6%), and high DMFT index (37.3% vs. 27.8%) ( P < 0.001 for all). In multivariable analyses, denture status: removable partial denture (adjusted odds ratio [aOR], 1.12; 95% confidence interval [95% CI], 1.04–1.20) and complete denture (aOR, 1.52; 95% CI, 1.01–2.05), high DMFT index (aOR, 1.13; 95% CI, 1.02–1.24), and fewer permanent teeth (0–19; aOR, 1.32; 95% CI, 1.12–1.52) were significantly associated with AFL. Furthermore, those with severe to very severe AFL had a significantly higher proportion of complete denture (aOR, 2.41; 95% CI, 1.11–3.71) and fewer remaining teeth (0–19; aOR, 2.29; 95% CI, 1.57–3.01). Conclusion Denture wearing, high DMFT index, and fewer permanent teeth are significantly associated with AFL. Furthermore, a reduced number of permanent teeth (0–19) was significantly related to the severity of AFL. Therefore, physicians should pay attention to oral health in managing patients with AFL, such as chronic obstructive pulmonary disease.

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Section: Discussionmentioning

confidence: 99%

Association Between Oral Health and Airflow Limitation: Analysis Using a Nationwide Survey in Korea

Kim

et al. 2023

J Korean Med Sci

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“…This inhaled medication can impact dental and oral health depending on the dose, frequency, and duration of use. (16) Conditions that are often encountered due to long-term side effects of inhaled drugs are xerostomia, dental caries, oral candidiasis, gingivitis, impaired sense of taste, and periodontitis. The underlying pathophysiology is the presence of inhaled drug residues in the oral cavity and oropharynx.…”

Section: Impact Of Copd On Oral Health Problemsmentioning

confidence: 99%

Bidirectional relationship between chronic obstructive pulmonary disease and oral disease

Made Agustya Darma Putra Wesnawa,

Putu Mariati Kaman Dewi

2024

World J. Adv. Res. Rev.

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Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that has various comorbid conditions and systemic complications. One of the complications is dental and oral disease, which can occur through systemic inflammatory mechanisms and the long-term side effects of inhaled drugs. Dental and oral diseases can also cause COPD progression, increase the risk of exacerbations, and affect the patient's quality of life. Some mechanisms that may play a role include aspiration of oral pathogens, aspiration of inflammatory proteins, and systemic inflammation. Dysbiosis of the lung microbiome can result from dental and oral conditions, increasing the risk of COPD and pulmonary infections. The association between COPD and oral disease includes the presence of systemic inflammatory conditions, the risk factor of smoking, and the indirect effects of inhaled medication use. Comprehensive management of COPD patients regarding dental and oral health is needed, which includes prevention of dental and oral disease, routine assessment of dental and oral health, provision of specific dental therapy, and personalized treatment in selecting COPD therapy.

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“…Khijmatgar et al reported that oral Candida was more common in the COPD group than in the controls (21.42% vs. 1.1%). They also observed higher DMFT and significant caries index scores in patients with COPD [ 98 ].…”

Section: Biological Mechanisms Underlying This Relationshipmentioning

confidence: 99%

“…Anticholinergics may also decrease salivary production and can interfere with the clearance of oral bacteria [ 113 ]. Theophylline medication can be a risk factor for increased candidal load in patients with COPD [ 98 ].…”

Section: Biological Mechanisms Underlying This Relationshipmentioning

confidence: 99%

Putative Bidirectionality of Chronic Obstructive Pulmonary Disease and Periodontal Disease: A Review of the Literature

Tamiya,

Mitani,

Abe

et al. 2023

JCM

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The prevalence of chronic obstructive pulmonary disease (COPD) is increasing worldwide and is currently the third leading cause of death globally. The long-term inhalation of toxic substances, mainly cigarette smoke, deteriorates pulmonary function over time, resulting in the development of COPD in adulthood. Periodontal disease is an inflammatory condition that affects most adults and is caused by the bacteria within dental plaque. These bacteria dissolve the gums around the teeth and the bone that supports them, ultimately leading to tooth loss. Periodontal disease and COPD share common risk factors, such as aging and smoking. Other similarities include local chronic inflammation and links with the onset and progression of systemic diseases such as ischemic heart disease and diabetes mellitus. Understanding whether interventions for periodontal disease improve the disease trajectory of COPD (and vice versa) is important, given our rapidly aging society. This review focuses on the putative relationship between COPD and periodontal disease while exploring current evidence and future research directions.

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Oral Candidal Load and Oral Health Status in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Case-Cohort Study

Abstract: Objective. The objective of this study was to determine the candidal load of the patients with Chronic Obstructive Pulmonary Disease (COPD) and evaluate the oral health status of subjects with COPD. Material and Methods. N = 112 COPD subjects and N = 100 … Show more

Cited by 9 publications

References 33 publications

Association Between Oral Health and Airflow Limitation: Analysis Using a Nationwide Survey in Korea

Association Between Oral Health and Airflow Limitation: Analysis Using a Nationwide Survey in Korea

Bidirectional relationship between chronic obstructive pulmonary disease and oral disease

Putative Bidirectionality of Chronic Obstructive Pulmonary Disease and Periodontal Disease: A Review of the Literature

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