Oral candidiasis in patients with psoriasis: Correlation of oral examination and cytopathological evaluation with psoriasis disease severity and treatment

Picciani, Bruna Lavinas Sayed; Michalski-Santos, Bruna; Carneiro, Sueli; Sampaio, Ana Luisa; Avelleira, João Carlos Regazzi; Azulay, David Rubem; Pinto, Jony Arrais; Dias, Eliane Pedra

doi:10.1016/j.jaad.2012.11.033

Cited by 47 publications

(80 citation statements)

References 23 publications

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“…Although the triggers for PsA are not clear, various infections, inflammation-induced stimuli, and physical injuries to the skin (the "Koebner response") were shown to initiate/exacerbate psoriatic lesions (6). Candida infections usually lead to different skin pathologies, and increased oral Candida albicans infections were reported in patients with Ps (7).…”

mentioning

confidence: 99%

Mannan induces ROS-regulated, IL-17A–dependent psoriasis arthritis-like disease in mice

Khmaladze

Kelkka

Guérard

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

130

168

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Significance We identified a previously undescribed disease mechanism for psoriasis (Ps) and psoriasis arthritis (PsA)-like disease by developing a new mouse model having characteristic features similar to those of Ps and PsA in human patients. Mannan-induced activation of tissue macrophages triggers IL-17A secretion from γδ T cells, causing Ps-like inflammation. Such inflammation was significantly increased under a reduced oxidative environment. Increased frequency of monocytes/macrophages, depletion experiments, and the disease suppressor function of macrophage-derived reactive oxygen species clearly argue in favor of a role for monocytes/macrophages in this disease model, which is in accordance with the findings in patients with the psoriatic form of skin lesions and arthritis. This novel PsA model could be immensely useful to test new therapeutics for patients with Ps and PsA.

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mentioning

confidence: 99%

Mannan induces ROS-regulated, IL-17A–dependent psoriasis arthritis-like disease in mice

Khmaladze

Kelkka

Guérard

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

130

168

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“…in healthy and asymptomatic populations (4,26,34,40) . According to Odds (1994), the diagnosis of oral candidiasis cannot be made adequately only by clinical findings: it must be based on the presence of clinical signs allied to the observation of hyphae or pseudohyphae at cytopathology (32) .…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of Candida spp. in the oral cavity of clinically normal patients ranges from 3% to 48%; it is found in healthy children, young adults and, with a higher prevalence, in hospitalized patients (4,34,35) . Oral candidiasis has a variable clinical presentation, and its diagnosis is based on symptoms and clinical aspects, in association with medical history (3,24,36,39,45) .…”

mentioning

confidence: 99%

Comparative analysis of Gram’s method and PAS for the identification ofCandidaspp. samples from the oral mucosa

Padilha¹,

Picciani²,

Santos

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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“…albicans in patients with psoriasis compared to healthy controls correlates with disease severity (26). C. albicans is an opportunistic dimorphic fungus that causes mucocutaneous and systemic candidiasis, usually colonizing humans since birth and persisting throughout life as a commensal in the skin and the oral, gastrointestinal, and vaginal mucosae.…”

Section: Skin Inflammatory Disease Atopic Dermatitismentioning

confidence: 99%

“…C. albicans is an opportunistic dimorphic fungus that causes mucocutaneous and systemic candidiasis, usually colonizing humans since birth and persisting throughout life as a commensal in the skin and the oral, gastrointestinal, and vaginal mucosae. The mouth is a suitable place for colonized Candida, and oral candidiasis is frequently present in the mouths of patients with psoriasis (26). Indeed, treatment with a systemic antifungal is very effective in some psoriatic patients, particularly those with mouth lesions (27).…”

Section: Skin Inflammatory Disease Atopic Dermatitismentioning

confidence: 99%

Mast Cells and Microbiome in Skin Immunity

Park

Cho

2017

J Bacteriol Virol

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The skin functions as a physical barrier against entry of pathogens while concomitantly supporting a myriad of commensal organisms. The characterization of these microbial communities has enhanced our knowledge of the ecology of organisms present in normal skin, and studies have begun to illuminate the intimate relationship between the host and resident microbes. The cutaneous innate and adaptive immune responses can modulate skin microbiota, while simultaneously, the microbiota educates the host immune system. A crucial element of the innate immune response is mast cells, which reside strategically in tissues that are commonly exposed to the external environment, such as the skin and mucosae. Mast cells are present on the frontline of defense against pathogens, suggesting they may play an important role in fostering the host-microbiota relationship. In this review, we highlight findings regarding the interaction between skin microbiota and mast cells and the resulting outcomes in skin homeostasis.

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Oral candidiasis in patients with psoriasis: Correlation of oral examination and cytopathological evaluation with psoriasis disease severity and treatment

Cited by 47 publications

References 23 publications

Mannan induces ROS-regulated, IL-17A–dependent psoriasis arthritis-like disease in mice

Mannan induces ROS-regulated, IL-17A–dependent psoriasis arthritis-like disease in mice

Comparative analysis of Gram’s method and PAS for the identification ofCandidaspp. samples from the oral mucosa

Mast Cells and Microbiome in Skin Immunity

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