2022
DOI: 10.1111/odi.14176
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Oral carcinogenesis triggers a nociceptive behavior and c‐Fos expression in rats’ trigeminal pathway

Abstract: Objective To recognize changes that occur along the trigeminal pathway in oral cancer in order to establish an effective approach to pain control. Methods Wistar rats were divided into control and 4‐NQO groups for 8, 12, 16, or 20 weeks. 4‐NQO suspension was administered on the animals’ tongues. Mechanical hyperalgesia, assessment of facial expressions, and an open‐field test were performed. After euthanasia, the animals’ tongues were removed for macro‐ and microscopic analysis. c‐Fos expression was analyzed i… Show more

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