Oral Carriage of <i>Helicobacter pylori</i>: A Review

Madinier, I.; Fosse, T.; Monteil, R

doi:10.1902/jop.1997.68.1.2

Cited by 63 publications

(52 citation statements)

References 44 publications

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“…2). Accordingly to these results, several important pathogenic microorganisms have been identified in the oral cavity, such as H. pylori (21), B. cereus (15), viruses (7), S. aureus (16,18,27,28), respiratory pathogens and enteric bacilli (32). These observations support the idea that the oral cavity may act as a reservoir and a source of these microorganisms to other area of the body.…”

Section: Figuresupporting

confidence: 59%

“…For instance, a higher prevalence of respiratory pathogens such as Pseudomonas aeruginosa colonizing the dental biofilm has been observed in hospitalized patients and elderly institutionalized individuals (31). In addition, Helycobacter pylori, a pathogen associated with the development of peptic ulcers and gastric cancer, has been frequently detected in the dental biofilm and saliva of subjects with periodontitis (21). One aspect that should be pointed out is that eradication of these pathogens from dental biofilm may be more difficult due to their greater resistance to antimicrobials, increasing the risk of treatment failure and reinfection in these individuals (8,32).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Souto¹,

Andrade²,

Uzeda³

et al. 2006

Braz. J. Microbiol.

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The oral cavity may act as a reservoir for several pathogens related to systemic infections. Therefore, the purpose of this study was to determine the prevalence and levels of pathogenic bacteria in the subgingival biofilm of chronic periodontitis lesions and healthy periodontal sites using the checkerboard DNA-DNA hybridization technique. 200 samples of subgingival biofilm from sites with periodontitis (probing pocket depth ≥ 4 mm and /or clinical attachment level ≥ 4 mm) and 200 samples from healthy sites of 14 patients with chronic periodontitis, as well as 200 samples from 3 periodontally healthy patients were obtained. The presence and levels of 11 pathogenic bacteria were determined using whole genomic DNA probes and the checkerboard method, computed for each site and then across sites within each subject group. Significance of differences in clinical and microbiological parameters among groups were examinated using the MannWhitney and Wilcoxon sign tests. The predominant species in all 600 samples included Corynebacterium diphtheriae, Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii and Escherichia coli. In general, most of the species were detected in greater prevalence and levels in sites with and without disease from patients with periodontitis in comparison to the periodontally healthy group. In particular, C. diphtheriae, E. coli, E. faecalis, Pseudomonas aeruginosa and S. aureus were significantly more prevalent and detected in higher counts in diseased sites of patients with periodontal disease compared to healthy subjects (p < 0.05). Clinical signs of disease presented a positive correlation with the species A. baumannii, Streptococcus pyogenes, E. coli, S. aureus and P. aeruginosa. In conclusion, "non-oral" pathogenic bacteria are detected in high prevalence and levels in periodontal sites of chronic periodontitis patients.

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Section: Figuresupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Souto¹,

Andrade²,

Uzeda³

et al. 2006

Braz. J. Microbiol.

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“…The oral cavity may be a reservoir of this bacterium (Thomas et al, 1997). However, other authors maintain that H. pylori is present in the oral cavity due to regurgitation of contaminated gastric juice (Madinier et al, 1997). Our finding of Helicobacter sp.…”

contrasting

confidence: 40%

Evidence of Helicobacter sp. in Dental Plaque of Captive Dolphins (Tursiops gephyreus)

Goldman

Loureiro

Quse

et al. 2002

Journal of Wildlife Diseases

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Gastrointestinal lesions have been extensively reported in wild and captive marine mammals. However, their etiology remains unclear. In humans and other animals, chronic gastritis and peptic ulcers have been associated with Helicobacter sp. Therefore, the aim of our study was to investigate the presence of Helicobacter sp. in the gastric juice, dental plaque, and saliva of marine mammals living in a controlled environment. Five dolphins (Tursiops gephyreus), one killer whale (Orcinus orca), one false killer whale (Pseudorca crassidens), three sea lions (Otaria flavescens), two elephant seals (Mirounga leonina), and two fur seals (Arctocephalus australis) were studied. Saliva, dental plaque, and gastric juice samples were examined for Helicobacter sp. using polymerase chain reaction. None of the gastric juice or saliva samples were positive for Helicobacter sp. However, Helicobacter sp. DNA was detected in dental plaque from two dolphins, suggesting the oral cavity might be a reservoir of this bacterium.

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“…Because the mouth functions as the portal of entry to the gastrointestinal system, the possible role of the oral cavity in the transmission of Helicobacter pylori has been debated in recent years (22)(23)(24). H. pylori plays a causative role in the pathogenesis of gastritis, gastric atrophy, and peptic and duodenal ulcers (25,26).…”

Section: Introductionmentioning

confidence: 99%

Salivary MUC5B-Mediated Adherence (Ex Vivo) of Helicobacter pylori During Acute Stress

Bosch

Geus

Ligtenberg

et al. 2000

Psychosomatic Medicine

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Objective: Biochemical host defenses at mucosal sites, such as the oral cavity, play a key role in the regulation of microbial ecology and the prevention of infectious disease. These biochemical factors have distinct features, some of which benefit the host and some that benefit bacteria. We investigated the effects of acute stress on the salivary levels of the carbohydrate structure sulfo-Lewis a (sulfo-Le a ), which is linked to the mucosal glycoprotein MUC5B. Sulfo-Le a was recently identified as an adhesion molecule for Helicobacter pylori; therefore, we also measured saliva-mediated adherence (ex vivo) of H. pylori. The oral cavity is suspected to be involved in the transmission of H. pylori. Methods: Saliva was collected from 17 undergraduates before (baseline), during (stress), and after (recovery) exposure to a video showing surgical procedures. In addition, blood pressure, an impedance cardiogram, and an electrocardiogram were recorded. Results: During stressor exposure, participants reported increased state anxiety. In addition, stroke volume increased and heart rate decreased. The stressor induced a strong increase in salivary sulfo-Le a concentration (U/ml), sulfo-Le a output (U/min), sulfo-Le a /total protein ratio (U/mg protein), and saliva-mediated adherence (ex vivo) of H. pylori. As expected, sulfo-Le a concentration correlated with the adherence of H. pylori (r ϭ 0.72, p Ͻ .05). It was demonstrated that the observed adherence was induced by MUC5B and that the carbohydrate structure sulfo-Le a contributed to this process. Conclusions: Our study demonstrated a direct link between stress-mediated biochemical changes and altered host-microbe interactions in humans. Increased bacterial adherence may be a contributing factor in the observed relationship between stress and susceptibility to infectious disease.

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Oral Carriage of Helicobacter pylori: A Review

Cited by 63 publications

References 44 publications

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Evidence of Helicobacter sp. in Dental Plaque of Captive Dolphins (Tursiops gephyreus)

Salivary MUC5B-Mediated Adherence (Ex Vivo) of Helicobacter pylori During Acute Stress

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