Oral carriage of staphylococci in patients with rheumatoid arthritis

Jackson, Margaret S.; Bagg, J.; Gupta, Monica; Sturrock, R. D.

doi:10.1093/rheumatology/38.6.572

Cited by 73 publications

(55 citation statements)

References 5 publications

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“…2). Accordingly to these results, several important pathogenic microorganisms have been identified in the oral cavity, such as H. pylori (21), B. cereus (15), viruses (7), S. aureus (16,18,27,28), respiratory pathogens and enteric bacilli (32). These observations support the idea that the oral cavity may act as a reservoir and a source of these microorganisms to other area of the body.…”

Section: Figuresupporting

confidence: 60%

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Souto¹,

Andrade²,

Uzeda³

et al. 2006

Braz. J. Microbiol.

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The oral cavity may act as a reservoir for several pathogens related to systemic infections. Therefore, the purpose of this study was to determine the prevalence and levels of pathogenic bacteria in the subgingival biofilm of chronic periodontitis lesions and healthy periodontal sites using the checkerboard DNA-DNA hybridization technique. 200 samples of subgingival biofilm from sites with periodontitis (probing pocket depth ≥ 4 mm and /or clinical attachment level ≥ 4 mm) and 200 samples from healthy sites of 14 patients with chronic periodontitis, as well as 200 samples from 3 periodontally healthy patients were obtained. The presence and levels of 11 pathogenic bacteria were determined using whole genomic DNA probes and the checkerboard method, computed for each site and then across sites within each subject group. Significance of differences in clinical and microbiological parameters among groups were examinated using the MannWhitney and Wilcoxon sign tests. The predominant species in all 600 samples included Corynebacterium diphtheriae, Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii and Escherichia coli. In general, most of the species were detected in greater prevalence and levels in sites with and without disease from patients with periodontitis in comparison to the periodontally healthy group. In particular, C. diphtheriae, E. coli, E. faecalis, Pseudomonas aeruginosa and S. aureus were significantly more prevalent and detected in higher counts in diseased sites of patients with periodontal disease compared to healthy subjects (p < 0.05). Clinical signs of disease presented a positive correlation with the species A. baumannii, Streptococcus pyogenes, E. coli, S. aureus and P. aeruginosa. In conclusion, "non-oral" pathogenic bacteria are detected in high prevalence and levels in periodontal sites of chronic periodontitis patients.

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Section: Figuresupporting

confidence: 60%

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Souto¹,

Andrade²,

Uzeda³

et al. 2006

Braz. J. Microbiol.

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“…12 The end result is joint destruction and systemic sepsis. • History of chronic disease 9 • Superficial skin ulceration or other minor primary infection 5,9 • Oral carriage of Staphylococcus aureus 10 • Prosthetic joint 5,7 • Diabetes 5…”

Section: Pathophysiologymentioning

confidence: 99%

Septic arthritis in patients with pre-existing inflammatory arthritis

Kherani¹,

Shojania²

2007

Canadian Medical Association Journal

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The case: A 56-year-old woman presents to her family physician with a 7-day history of tenderness, swelling and redness of 2 metacarpophalangeal joints and 1 proximal interphalangeal joint in her right hand. She also reports pain and redness of her right knee that makes it difficult to walk. On examination, her right knee appears swollen and red. The patient has a 10-year history of rheumatoid arthritis with intermittent polyarticular flares, primarily involving her wrists, fingers (metacarpophalangeal and proximal interphalangeal joints), feet (metatarsophalangeal joints) and occasionally her knees. However, the condition has been well managed with methotrexate and hydroxychloroquine therapy. She had no flares in the year before presentation and is able to perform household chores and to work as a dry-cleaning attendant. What other history, physical examination and laboratory investigations would you seek to distinguish a simple flare of inflammatory polyarthritis from a superimposed infection?

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“…Indeed the human oral cavity is extensively populated with a vast variety of microbes out of which S. aureus having reported a carriage rate of 24-84% in healthy oral cavity and 48% incidence among the denture-wearing population [19], takes the credit for causing majority of the deleterious clinical diseases involving the hard and soft tissue of the mouth [20]. Since its spread by contact is vividly documented in literature posing a great deal of threat to the dental personnel, this study therefore provides a significantly useful alternative to control the pathologies connected with S. aureus and other associated microbes.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Property of Hydrocolloid Impression Material Incorporated with Silver Nanoparticles AgainstStaphylococcusAureus

et al. 2017

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Abstract. Dental impressions can easily become contaminated with patient's blood and saliva which are capable of transmitting infectious diseases to dental personnel. The addition of antimicrobial agents into impression materials could be effective in reducing the chances of cross-infection. Silver nanoparticles have been applied in dentistry as a potent antimicrobial agent. This study aims to evaluate the in vitro antimicrobial efficacy of silver nanoparticles incorporated to irreversible hydrocolloid impression material against Staphylococcus aureus. Silver nanoparticles (AgZrPO4, National Direct Network Company, Thailand) at concentrations of 0.25%, 0.50%, 1.00% and 1.50% w/w were added to powder of impression materials (Kromopan, Lascod, Ilaty). Impression material samples were prepared on sterile plate in accordance with manufacturer's instruction. After setting, a 100 microliter of S. aureus ATCC6538 suspension (10 6 cells/mL) were inoculated on the surface of the impression sample and left for 10 minutes. The amount of S. aureus on the surface was quantified using imprint technique on Mannitol Salt agar. Impression materials incorporated with AgZrPO4 showed antimicrobial property against S. aureus (up to 95% reduction) compared with control (impression material without AgZrPO4). Even though the mechanism of antimicrobial action was not clearly understood, AgZrPO4 incorporated to impression material was demonstrated to possess an inhibitory effect against pathogenic bacteria. Further studies are needed to investigate physical properties of the material and the clinical usage.

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Oral carriage of staphylococci in patients with rheumatoid arthritis

Abstract: Oral carriage of S. aureus appears to be common in patients with rheumatoid arthritis and studies of the mouth as a source of infection in septic arthritis would be merited.

Cited by 73 publications

References 5 publications

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Septic arthritis in patients with pre-existing inflammatory arthritis

Antimicrobial Property of Hydrocolloid Impression Material Incorporated with Silver Nanoparticles AgainstStaphylococcusAureus

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