Oral cavity infection: an adverse effect after the treatment of oral cancer in aged individuals

Abstract

ObjectiveThe immune compromised patients after treatment of oral cancer may have a chance of infection by drug-resistant opportunistic microbes. We investigated the occurrence of opportunistic microorganisms in aged individuals receiving follow-up examinations after treatment of oral cancer in China. Material and MethodsThese patients were used as test group and the respective age grouped healthy individuals as control group. In this study, the oral cavity microorganisms such as bacteria and yeast were taken for the analysis. After the screening of representative microorganisms, their aptitude of pervasiveness against drugs was studied. Here, we used antimicrobial agents which are common in clinical practice. We also performed studies to investigate the presence of toxin genes in methicillin-resistant S. aureus (MRSA). ResultsThe results indicate that the prevalence of drug-resistant microbes was more pronounced in oral cancer patients after initial treatment above 70 years old. The oxacillin resistance of S. aureus isolate confirms that the prevalence of MRSA is increasing in accordance to age-factor and immune compromise in elderly patients. ConclusionsThis study reveals the occurrence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer in aged individuals. Special attention should be directed to MRSA during the treatment of oral cancer, and to realize the fact of immune compromise in elderly patients.

RETRACTED: Efficacy of Chelerythrine against Mono- and Dual-Species Biofilms of Candida albicans and Staphylococcus aureus and Its Properties of Inducing Hypha-to-Yeast Transition of C. albicans

“…C. albicans, a dimorphic fungal organism, is present primarily in the oral cavity in a non-pathogenic yeast state in C T E D about one half of healthy individuals, but, under nutrition-rich conditions, has the ability to switch to a disease-causing hyphae form [4]. Under poor oral health conditions, pathogens including methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa were easy to colonize in the oral cavity [5]. Oral microorganisms adhere to a surface and evolve to persist in the varying environments in protective biofilms [6].…”

Prevalence of methicillin resistant Staphylococcus aureus isolated from saliva samples of patients with oral squamous cell carcinoma

“…Specific bacterial markers in saliva in oral cancers can be used in planning of new treatment options for cancer prevention. 23 Similarly, occurrence of MSRA in OSSC cases can be used as an early diagnostic marker for OSCC. However, more analysis and research is required in this subject to find a clearer association between MRSA or other bacterial species and OSCC.…”

Bacteria Modify Candida albicans Hypha Formation, Microcolony Properties, and Survival within Macrophages

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