Oral cavity metastasis of renal cell carcinoma: A case report

Will, Thomas; Agarwal, Nidhi; Petruzzelli, Guy J.

doi:10.1186/1752-1947-2-313

Cited by 51 publications

(46 citation statements)

References 9 publications

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“…However the patient's treatment was changed to targeted therapy with sunitinib and sorafenib because of progressive disease. Will et al reported that most patients die within 1 year after the detection of head and neck metastasis [18]. Campbell et al reported the overall 5-and 10-year survival rates of patients with metastatic RCC are 5-30% and 0-5%, respectively [19].…”

Section: Discussionmentioning

confidence: 99%

Lingual metastasis as an initial presentation of renal cell carcinoma

et al. 2010

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Distant metastasis of malignant neoplasm to the oral soft tissue is extremely rare. We report a case of renal cell carcinoma (RCC) metastasizing to the tongue. A 47-year-old man visited our hospital with chief complaint of a lump on the middle third of the dorsum of his tongue, and the lesion fell off from the tongue. Although histopathological diagnosis of the mass was granuloma teleangiecaticum, similar nodule reappeared in the same area 2 weeks later. The second lesion was composed of granuloma teleangiectaticum and aggregation of neoplastic clear cells in ductal arrangement. The clear cells were immunohistochemically positive for EMA and CD10.The abdominal CT scan revealed a 5.5 cm mass in the left kidney, suggesting RCC.Thus the lingual lesion was consistent with metastaic RCC. There has been no recurrence for 2 years after the radical nephrectomy and local exicision of the tongue.

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Section: Discussionmentioning

confidence: 99%

Lingual metastasis as an initial presentation of renal cell carcinoma

et al. 2010

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“…12 It has been mentioned in the literature that the common site of metastatic renal cell carcinoma in the oral cavity is tongue. Possible routes of metastatic spread to the tongue include lymphatic, arterial and venous spread.…”

Section: Discussionmentioning

confidence: 99%

Metastatic renal cell carcinoma in the head and neck region

Gandla

Ramaswamy

Rao

2018

Int J Otorhinolaryngol Head Neck Surg

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<p>We describe 3 rare cases of metastatic renal cell carcinoma in the head and neck region. Our first case was a 72 years old male presented with profuse bleeding from the left ear. On examination, proliferative, pink, friable mass was present in the left external auditory canal. On eliciting the detailed history, it was found that patient had renal cell carcinoma in the left kidney four years back and underwent left radical nephrectomy. Patient underwent left lateral temporal bone resection with cul-de-sac closure. Histopathological examination of the specimen showed metastatic renal cell carcinoma. Our second case was a 64 years old male presented with complaints of growth in the oral cavity of 1 month duration. On examination, 5×3 cms proliferative growth was present in the hard palate. Biopsy from the growth in the hard palate showed metastatic renal cell carcinoma. Patient gave history of renal cell carcinoma in the past for which he did not receive treatment. Our third case was a 45 years old male who presented to us with a diffuse swelling in the left temporal region of 2 months duration. On examination, 3×2 cms swelling was present in the left temporal region. Patient had history of renal cell carcinoma of left kidney and underwent left nephrectomy one year prior to the presentation of the left temporal swelling. Ultrasonography guided biopsy of the left temporal region showed metastatic renal cell carcinoma.</p>

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“…Bu lezyonlar, ana tümör olan RHK gibi radyoterapi ve kemoterapiye dirençlidir. Ancak uygulanan lokal radyoterapi, semptomlarda kısa süreli rahatlama sağlayabilir (13). Metastatik RHK olgularında kullanılan hedefe yönelik immunoterapötik ajanlar, bu olgularda kullanılsa da sağ kalıma katkısı azdır.…”

Section: Olgu Sunumuunclassified

Gingiva Metastasis of Renal Cell Carcinoma: A Rare Case Report

Öztürk¹,

Selvi²,

Yıkılmaz³

et al. 2017

Acta Oncol Tur.

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ÖZETRenal hücreli karsinom, meme ve akciğer kanserlerinden sonra oral kaviteye metastaz yapan en sık üçüncü malignite olsa da, oldukça nadir görülmektedir. Gingivada metastaz yapması ise oransal olarak daha azdır ve bu tümörlerin ayırıcı tanıda akla gelmesi oldukça zordur. Genel olarak baş boyun bölgesine metastaz yapmış renal hücreli karsinomların prognozu oldukça kötü olup, bu aşamadan sonra beklenen sağ kalım 1 yıldan daha azdır. Tanıdan 1 ay sonra kosta metastazı gelişen renal hücre karsinomlu 51 yaşında bir erkek hastada, hedefe yönelik tedavilere rağmen, 42. ayda oluşan gingiva metastazı olgusunu sunduk. Anahtar Kelimeler: Çene kemiği osteonekrozu, gingiva, metastaz, oral kavite, renal hücreli karsinom ABSTRACT Renal cell carcinoma is the third most common malignancy that metastasizes to the oral cavity after breast and lung cancers, but it is rarely seen. Metastasis to the gingiva is proportionally less and it is difficult for these tumors to come to mind in the differential diagnosis. Generally, the prognosis of renal cell carcinoma metastasizing to the head and neck region is quite poor and the expected survival is less than 1 year. We presented a 51-year-old male patient with renal cell carcinoma, developing costa metastasis 1 month after diagnosis and showing gingiva metastasis at 42th months despite targeted treatment. Keywords: Gingiva, jaw bone osteonecrosis, metastasis, oral cavity, renal cell carcinoma GirişRenal hücreli karsinom (RHK), erişkin tümörlerin %3'ünü oluşturmakta ve oldukça ölümcül seyretmektedir. Tanı anında olguların yaklaşık %20-30'u metastatiktir. Yüksek vaskülarite özelliğinden dolayı, uzak anatomik lokalizasyonlara metastaz olma eğilimindedir. Metastazlar en çok akciğer, kemik ve lenf nodlarına olmaktadır.Baş boyun bölgesine metastaz yaygın değildir, olguların yaklaşık % 6-18' inde görülür (1). Oral kavite metastazı ise çok daha nadirdir ve tüm oral kavite malign tümörlerinin ancak %1'ini oluşturur. Oral kaviteye metastaz yapan en sık infraklaviküler malignite erkeklerde akciğer, kadınlarda meme kanseridir. RHK ise en sık gözlenen üçüncü malignitedir. Maksillofasiyal bölgede, RHK metastazından en sık etkilenen alan nazal kavite ve paranazal sinüslerdir ve bunları oral kavite izler. RHK öyküsü olan hastalarda, yeni gelişen oral kavite ve maksillofasiyal kitle varlığında, RHK metastazı akla gelmelidir.Metastatik RHK tanısı nedeniyle hedefe yönelik tedavi başlanmasına rağmen, progresyon gösteren ve 42 ay sonra gingiva metastazı yapan bir olgu sunduk.

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Oral cavity metastasis of renal cell carcinoma: A case report

Cited by 51 publications

References 9 publications

Lingual metastasis as an initial presentation of renal cell carcinoma

Lingual metastasis as an initial presentation of renal cell carcinoma

Metastatic renal cell carcinoma in the head and neck region

Gingiva Metastasis of Renal Cell Carcinoma: A Rare Case Report

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