Oral Cholecystography with Iopanoic Acid

Berk, Robert N.; Loeb, Peter M.; Goldberger, Lawrence E.; Sokoloff, Joel

doi:10.1056/nejm197401242900406

Cited by 54 publications

(7 citation statements)

References 55 publications

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“…The mechanism responsible for acute renal failure following administra tion of contrast materials is not known but a direct nephrotoxic effect seems most likely [27][28][29], The finding of acute tubular necrosis clinically supports this view. Experimentally, acute tubular necrosis has been induced in the dog by aortic injection of various radio-contrast agents [30,31], and investigators have concluded that these materials have a direct toxic effect on the renal tubule.…”

Section: Discussionmentioning

confidence: 98%

Acute Renal Failure due to Radio-Contrast Agents

Ansari

Baldwin²

1976

Nephron

114

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Over a 2-year period, acute renal failure following radio-contrast studies was observed in 25 patients after intravenous urography in 13, angiography in 10, oral cholecystography in 1, and cholangiography in 1. 20 had impaired renal function prior to the study. Renal failure, oliguric in 16 patients, occurred within 24 h. Serum creatinines reached levels of 5.3–13.3 mg% in 3–10 days. Recovery occurred in 20 patients within 5–37 days. Among the 5 patients in whom renal function was not restored, 1 died of progressive underlying renal disease and 4 of other causes while still in acute renal failure. These observations demonstrate the not infrequent occurrence of severe oliguric renal failure following radio-contrast study in patients with preexisting renal disease.

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Section: Discussionmentioning

confidence: 98%

Acute Renal Failure due to Radio-Contrast Agents

Ansari

Baldwin²

1976

Nephron

114

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“…Nevertheless, iodine has been demonstrated in adipose tissue for as long as 2 years after oral cholecystography (63). Other potential adverse effects include rash, thrombocytopenia, headache, nausea, vomiting, diarrhea, dysuria, uricosuria, and renal insufficiency (64)(65)(66)(67).…”

Section: Comparison With Other Antithyroid Drugsmentioning

confidence: 99%

The Use of Oral Radiographic Contrast Agents in the Management of Hyperthyroidism

Fontanilla

Schneider²,

Sarne³

2001

Thyroid

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Oral iodinated radiographic contrast agents such as ipodate and iopanoic acid form an important part of the armamentarium used to treat hyperthyroidism. They rapidly and dramatically reduce serum triiodothyronine (T3) levels by inhibiting conversion of thyroxine (T4) to T3 in the periphery and by blocking secretion from the thyroid. Potential risks from the large iodine load resulting from their use limit their widespread applicability. In addition, they are ineffective when used alone on a long-term basis. However, these agents may be especially useful in treating thyrotoxic patients preoperatively, in neonatal Graves' disease, in massive levothyroxine ingestion, and when other conventional antithyroid drugs are unsuccessful or contraindicated.

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“…Indeed, diarrhea is seen 2 to 10 times more often with Telepaque than with the other currently used OCG agents [6][7][8]. Presumably this difference relates to the poorer gastrointestinal absorption of Telepaque with subsequent greater irritation of the bowel [3]. Cholebrine (3.0g dose) has shown the lowest incidence of gastrointestinal side effects [7].…”

Section: Minor Reactions To Oral Cholecystographic Agentsmentioning

confidence: 99%

“…doses have been given [3]. Other cholecystographic agents used in the United States include sodium tyropanoate (Bilopaque | ipodate sodium (Oragrafin| and iocetamic acid (Cholebrine| All are based on the triiodinated benzene ring, but with alterations of the radical groups at the first and third positions of the aromatic ring ( Fig.…”

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confidence: 99%