Oral Cholera Vaccine Coverage, Barriers to Vaccination, and Adverse Events following Vaccination, Haiti, 20131

Tohme, Rania A.; François, Jeannot; Wannemuehler, Kathleen; Iyengar, Preetha; Dismer, Amber; Adrien, Paul; Hyde, Terri B.; Marston, Barbara J.; Date, Kashmira; Mintz, Eric D.; Katz, Mark A.

doi:10.3201/eid2106.141797

Cited by 41 publications

(41 citation statements)

References 23 publications

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“…Some reasons for partial and non-acceptance of OCV such as lack of time and fear of side effects were consistent with reasons found in other settings and with reasons captured in WHO's vaccine coverage survey data from the PoCs [5][6][7]. These reasons are increasingly important aspects of research on vaccination uptake as public perceptions have led to declines in rates of routine vaccination, and to barriers to the introduction of new vaccinations [9,10].…”

Section: Discussionsupporting

confidence: 65%

“…Fear of illness from combining the vaccine with alcohol and the perception of alcohol as a means for personal resilience affected decisions. The problem of alcohol abuse in conflict-affected populations warrants further study since it relates to behaviors that lead to greater risk of cholera and as a potential contributor to lower rates of vaccination among men [5,6,12].…”

Section: Discussionmentioning

confidence: 97%

“…followed by lack of information about the campaign, sickness and fear of possible side effects [7]. OCV campaigns in Haiti, Guinea and Thailand indicated a lower level of acceptance among adult men [5,6].…”

Section: Introductionmentioning

confidence: 95%

“…Only 7 countries have documented experiences with OCV campaigns and reasons influencing vaccine acceptance, three of which included humanitarian actors [4]. In Guinea and Haiti, non-vaccination was mostly attributed to being absent during the time of the campaign [5,6]. The greatest barrier to OCV uptake in Tanzania was described as an extended absence from home because of competing obligations or priorities in relation to work, education or visiting relatives.…”

Section: Introductionmentioning

confidence: 97%

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Perceptions of oral cholera vaccine and reasons for full, partial and non-acceptance during a humanitarian crisis in South Sudan

Peprah

Palmer

Rubin

et al. 2016

Vaccine

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Perceptions of oral cholera vaccine and reasons for full, partial and non-acceptance during a humanitarian crisis in South Sudan

Peprah

Palmer

Rubin

et al. 2016

Vaccine

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show abstract

“…This finding suggests a need to remind vaccine recipients to bring back vaccination cards for the second round and to improve vaccination card recording training for vaccination teams. Previous OCV campaigns in Haiti that reported higher card-documented 2-dose coverage (51%–70%) emphasized the value of keeping vaccination cards for receiving the second vaccine dose ( 21 ). Where feasible, the use of serologic studies may also be helpful in validating reported coverage.…”

Section: Discussionmentioning

confidence: 99%

Oral Cholera Vaccine Coverage during an Outbreak and Humanitarian Crisis, Iraq, 2015

Lam¹,

Al-Tamimi²,

Russell³

et al. 2017

Emerg. Infect. Dis.

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During November–December 2015, as part of the 2015 cholera outbreak response in Iraq, the Iraqi Ministry of Health targeted ≈255,000 displaced persons >1 year of age with 2 doses of oral cholera vaccine (OCV). All persons who received vaccines were living in selected refugee camps, internally displaced persons camps, and collective centers. We conducted a multistage cluster survey to obtain OCV coverage estimates in 10 governorates that were targeted during the campaign. In total, 1,226 household and 5,007 individual interviews were conducted. Overall, 2-dose OCV coverage in the targeted camps was 87% (95% CI 85%–89%). Two-dose OCV coverage in the 3 northern governorates (91%; 95% CI 87%–94%) was higher than that in the 7 southern and central governorates (80%; 95% CI 77%–82%). The experience in Iraq demonstrates that OCV campaigns can be successfully implemented as part of a comprehensive response to cholera outbreaks among high-risk populations in conflict settings.

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Model distinguishability and inference robustness in mechanisms of cholera transmission and loss of immunity

Lee

Kelly

Ochocki

et al. 2017

Journal of Theoretical Biology

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Mathematical models of cholera and waterborne disease vary widely in their structures, in terms of transmission pathways, loss of immunity, and a range of other features. These differences can affect model dynamics, with different models potentially yielding different predictions and parameter estimates from the same data. Given the increasing use of mathematical models to inform public health decision-making, it is important to assess model distinguishability (whether models can be distinguished based on fit to data) and inference robustness (whether inferences from the model are robust to realistic variations in model structure). In this paper, we examined the effects of uncertainty in model structure in the context of epidemic cholera, testing a range of models with differences in transmission and loss of immunity structure, based on known features of cholera epidemiology. We fit these models to simulated epidemic and long-term data, as well as data from the 2006 Angola epidemic. We evaluated model distinguishability based on fit to data, and whether the parameter values, model behavior, and forecasting ability can accurately be inferred from incidence data. In general, all models were able to successfully fit to all data sets, both real and simulated, regardless of whether the model generating the simulated data matched the fitted model. However, in the long-term data, the best model fits were achieved when the loss of immunity structures matched those of the model that simulated the data. Two parameters, one representing person-to-person transmission and the other representing the reporting rate, were accurately estimated across all models, while the remaining parameters showed broad variation across the different models and data sets. The basic reproduction number (ℛ0) was often poorly estimated even using the correct model, due to practical unidentifiability issues in the waterborne transmission pathway which were consistent across all models. Forecasting efforts using noisy data were not successful early in the outbreaks, but once the epidemic peak had been achieved, most models were able to capture the downward incidence trajectory with similar accuracy. Forecasting from noise-free data was generally successful for all outbreak stages using any model. Our results suggest that we are unlikely to be able to infer mechanistic details from epidemic case data alone, underscoring the need for broader data collection, such as immunity/serology status, pathogen dose response curves, and environmental pathogen data. Nonetheless, with sufficient data, conclusions from forecasting and some parameter estimates were robust to variations in the model structure, and comparative modeling can help to determine how realistic variations in model structure may affect the conclusions drawn from models and data.

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Oral Cholera Vaccine Coverage, Barriers to Vaccination, and Adverse Events following Vaccination, Haiti, 20131

Abstract: Coverage was comparable to or higher than that in other countries.

Cited by 41 publications

References 23 publications

Perceptions of oral cholera vaccine and reasons for full, partial and non-acceptance during a humanitarian crisis in South Sudan

Perceptions of oral cholera vaccine and reasons for full, partial and non-acceptance during a humanitarian crisis in South Sudan

Oral Cholera Vaccine Coverage during an Outbreak and Humanitarian Crisis, Iraq, 2015

Model distinguishability and inference robustness in mechanisms of cholera transmission and loss of immunity

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