Oral Ciprofloxacin Affects the Pharmacokinetics of Paracetamol in Saliva

Issa, Mohamed; Nejem, R’afat Mahmoud; El-Abadla, Naser S.

doi:10.2165/00044011-200626040-00007

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…Several studies that investigate the effects of some drugs/substances, including probenecid, mestranol, antipyrine, niprisan, ciprofloxacin, rutaecarpine, Vitex negundo Linn., and kale, on the pharmacokinetics of APAP in human beings and animals have been carried out (Kamali, ; Droździk et al ., ; Monshouwer et al ., ; Adzu et al ., ; Issa et al ., ; Lee et al ., ; Tripathi et al ., ; Yamasaki et al ., ). St. Omer and Mohammad () investigated the interaction between NAC and APAP in dogs.…”

Section: Pharmacokinetic Parameters (Mean ± Sd) Of N‐acetyl‐p‐aminophmentioning

confidence: 98%

Effect of N‐acetylcysteine on pharmacokinetics of acetaminophen in piglets

Qiu

Cao

et al. 2013

Vet Pharm & Therapeutics

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Section: Pharmacokinetic Parameters (Mean ± Sd) Of N‐acetyl‐p‐aminophmentioning

confidence: 98%

Effect of N‐acetylcysteine on pharmacokinetics of acetaminophen in piglets

Qiu

Cao

et al. 2013

Vet Pharm & Therapeutics

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“…Single-dose ciprofloxacin coadministration reduced single-dose acetaminophen C max by mean 30% and increased T max and t½ by means of 86% and 29%, respectively (all p < 0.05) [268]. The effects of single-dose acetaminophen coadministration on single-dose ciprofloxacin pharmacokinetics were non-significant [269].…”

Section: Metabolism Interactionsmentioning

confidence: 88%

Quinolones

Guay¹

2011

Drug Interactions in Infectious Diseases

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Fluoroquinolone (FQ) antimicrobials are among the most commonly used agents in the outpatient and institutional patient care environments. Due to this high frequency of utilization, the potential for deleterious drug-drug interactions with nonantimicrobials is also high. The majority of interactions with the FQs involve deleterious effects on the FQ component. These are also the most clinically-important interactions with these agents. Multivalent cations such as Mg , and other minerals as well as drugs such as sucralfate, lanthanum, sevelamer, and didanosine (the cation-supplemented version of the latter) can substantially reduce FQ bioavailability, leading the subtherapeutic drug concentrations at the infection site and clinical failure. Separation of dose administrations may or may not reduce the magnitude of these interactions. Ciprofloxacin, norfloxacin, and two experimental FQs in clinical trials (pazufloxacin and prulifloxacin) act as moderate cytochrome P450 enzyme inhibitors and may increase serum concentrations of theophylline and caffeine. Warfarin pharmacodynamics are variably affected by the FQs. The pharmacodynamic interactions between NSAIDs and FQs are only relevant if fenbufen is used concurrently with enoxacin or, possibly, prulifloxacin. Caution is warranted if sparfloxacin or moxifloxacin is used concurrently with other medications prolonging the QTc interval or if patients have other risk factors for prolongation of the QTc interval (e.g. abnormal QTc interval pre-treatment, electrolyte abnormalities, use of starvation-liquid diets, or history of heart disease). Fluoroquinolone antimicrobials can be used effectively and safely in the vast majority of patients if the clinician remembers those few drug-drug interactions that are clinically-important.

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Quinolones

Guay¹

2018

Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions

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Oral Ciprofloxacin Affects the Pharmacokinetics of Paracetamol in Saliva

Abstract: Concomitant administration of ciprofloxacin with paracetamol may result in a delayed onset of action of paracetamol.

Cited by 7 publications

References 7 publications

Effect of N‐acetylcysteine on pharmacokinetics of acetaminophen in piglets

Effect of N‐acetylcysteine on pharmacokinetics of acetaminophen in piglets

Quinolones

Quinolones

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