Oral ciprofloxacin versus intravenous cefuroxime as prophylaxis against postoperative infection in vascular surgery: A randomised double-blind, prospective multicentre study

Abstract

The infection rate was similar in the two groups. Thus, oral administration of ciprofloxacin is an attractive, cost-effective and safe alternative to prophylaxis in vascular patients capable of taking oral medication on the day of surgery.

Clinical practice guidelines for antimicrobial prophylaxis in surgery

“…872 A multicenter, randomized, double-blind, prospective trial of 580 patients undergoing arterial procedures involving the groin who received either two doses of ciprofloxacin 750 mg orally or three doses of cefuroxime 1.5 g i.v. on the day of the procedure found an SSI rate of 9.2% (27 patients) and 9.1% (26 patients), respectively, within 30 days of the procedure 889 Although oral ciprofloxacin was shown to be as effective as i.v. cefuroxime, this study did not address concerns about resistance with routine use of fluoroquinolones.…”

“…Prophylactic antimicrobials decrease the rate of infection after procedures involving the lower abdominal vasculature and procedures required to establish dialysis access. The follow-up time for patients with late surgical-site complications was at least once after hospital discharge (not further defined) for most studies, 829,865,871,[885][886][887] at one month, 869,871,888,889 at six months, 872 and at three years. 138 A meta-analysis of 10 randomized controlled trials in patients undergoing peripheral arterial reconstruction with biological or prosthetic graft procedures found an overall consistent reduction in SSIs with systemic antimicrobial prophylaxis compared with placebo (relative risk, 0.25; 95% CI, 0.17-0.38; p < 0.00001).…”

Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery

“…A multicenter, randomized, double-blind, prospective trial of 580 patients undergoing arterial procedures involving the groin who received either two doses of ciprofloxacin 750 mg orally or three doses of cefuroxime 1.5 g i.v. on the day of the procedure found an SSI rate of 9.2% (27 patients) and 9.1% (26 patients), respectively, within 30 d of the procedure [889] Although oral ciprofloxacin was shown to be as effective as i.v. cefuroxime, this study did not address concerns about resistance with routine use of fluoroquinolones [891].…”

“…Prophylactic antimicrobials decrease the rate of infection after procedures involving the lower abdominal vasculature and procedures required to establish dialysis access. The follow-up time for patients with late surgical site complications was at least once after hospital discharge (not further defined) for most studies [829,865,871,[885][886][887], at one month [869,871,888,889], at six months [872], and at three years [138].…”

A Randomized Prospective Study of Oral versus Intravenous Antibiotic Prophylaxis against Postoperative Infection after Sagittal Split Ramus Osteotomy of the Mandible

“…In other fields, Tuji et al [19] reported that the prophylactic effect of oral tosufloxacin was equivalent to that of intravenous cefotiam after transurethral resection of the prostate. Risberg et al [20] reported that oral ciprofloxacin was as effective as intravenous cefuroxime in peripheral vascular surgery involving the groin. When both methods are compared regarding costeffectiveness, the daily cost of oral levofloxacin at a dose of 100 mg t.d.s.…”