Oral Cleft Related-Genes may be Involved in Root Curvature of Maxillary Lateral Incisors

Abstract

The maxilla is formed by the medial nasal and maxillary processes fusion. The dental lamina develops from 2 origins connecting in the lateral incisor. The maxillary lateral incisor region is often affected by dental anomalies and clefting. It is possible that genes involved in oral cleft could also be associated with a variety of phenotypic variations in the maxillary lateral incisor. In this phenotype–genotype study, we explored the association between polymorphisms in the oral-cleft-related genes BMP2 and BMP4 and root curvature of maxillary lateral incisors. Cross-sectional study. Universities and private clinics. Panoramic radiographs and DNA from 231 patients were analyzed. Schneider method (1971) was applied to estimate the degree of root curvature of the maxillary lateral incisors and to classify the root as straight (5° or less) or curved (higher than 5°). Genetic polymorphisms in BMP2 (rs235768 and rs1005464) and BMP4 (rs17563) were genotyped. Statistical analysis was performed. A total of 401 teeth (199 left and 202 right) were evaluated. Genetic analysis demonstrated trends toward association for the rs1005464 in BMP2 ( P = .025) in co-dominant model and in dominant model ( P = .026) for left incisors. The rs235768 in BMP2 showed trends toward association with the degree of root curvature in left incisors in the recessive model ( P = .031). rs17563 in BMP4 also showed trends toward association with the degree of the root curvature in left incisors ( P = .019). BMP2 (rs235768 and rs1005464) and BMP4 (rs17563) might be involved in maxillary lateral incisor root curvature.

Evaluation of Root Dilaceration and Taurodontism in Children with and without Cleft Lip and Palate

“…In our study, the left maxillary region was found to be the most common localization of both cleft and root dilaceration, contrary to the expected outcome. Although genetic studies have reported common genes associated with these root anomalies and clefts, current findings are still insufficient to explain the same localization (Küchler et al, 2022). On the other hand, Hereman et al (2018) reported that there is a great risk for canine impaction at the cleft side in unilateral CLP patients.…”

Single Nucleotide Polymorphisms in RUNX2 and BMP2 contributes to different vertical facial profile

“…We also investigated SNPs in BMP4 and SMAD6 genes due to their previous association with skeletal malocclusions [ 8 ]. BMP4 is well-known for its involvement in cell differentiation, bone development and the studied SNP rs17563 is involved in craniofacial phenotypes [ 30 ]. BMP4 signaling is complex, with potential cross-talks, including SMAD signaling.…”