Oral colonization by anaerobic bacteria during childhood: role in health and disease

Könönen, Eija

doi:10.1111/j.1601-0825.1999.tb00090.x

Cited by 24 publications

(14 citation statements)

References 86 publications

(141 reference statements)

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“…The stability in their colonization pattern may thus fluctuate from time to time [van Winkelhoff et al, 2008;Crielaard et al, 2011]. Aggregatibacter actinomycetemcomitans, regarded by some as a putative periodontopathogen, especially in aggressive periodontitis of young individuals [Haubek et al, 2008] (previously designated "localized juvenile periodontitis"), should be an exception due to its facultative anaerobic character, not being sensitive for peroxides (catalase) and acids (low pH), having a good adhesion capacity and may successfully compete with streptococci and other early colonizers and can be frequently found in preschool children [Könönen, 1999;Cephas et al, 2011;Dominguez-Bello et al, 2010]. Some, including serious pathogens, such as Staphylococcus aureus, Klebsiella spp., Pseudomonas spp.…”

Section: The Core Microbiomementioning

confidence: 99%

“…The anaerobes are regularly present in the subgingival plaque, dorsum of the tongue, and saliva even in young healthy individuals, and are frequently found in young children as early as 6 months of age ("early colonizers" . Other anaerobes are late colonizers [Könönen, 1999], while it has been more controversial when socalled putative periodontal pathogens (Porphyromonas gingivalis, Tannerella forsythia and Treponema species) colonize the oral cavity [Darby and Curtis, 2001]. They are not detected regularly in the oral cavity by culture techniques, or are difficult to culture, although it is more likely that they are present in low numbers and will not be detected due to dilution or lack of selective and suitable media [Siqueira and Rocas, 2017].…”

Section: The Core Microbiomementioning

confidence: 99%

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Caries and Periodontitis: Contesting the Conventional Wisdom on Their Aetiology

Manji¹,

Dahlén

Fejerskov

2018

Caries Res

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We review the literature on the oral microbiome and the role of the microbiota in the development of dental caries and periodontitis. While most research has been focused on identifying one or more specific determinants of these diseases, the results have provided limited predictive value and have not been able to explain the variation in the distribution of these diseases observed in epidemiological or clinical studies. Drawing on existing knowledge about the nature of the oral microbiota, we suggest that a stochastic model based on the Weiner process provides simple and parsimonious explanations for the pathogenesis of both caries and periodontitis, making few assumptions, and providing explanations for phenomena that have hitherto proved difficult, or have required complex arguments, to explain. These diseases occur as the result of the dental hard tissues and periodontal tissues integrating the random “noise” caused by normal metabolic activities of commensal microorganisms in the dental biofilm. The processes that result in the progression and regression of caries and periodontitis may be considered as “natural,” rather than pathological, even if, when left unchecked over long periods of time, they can result in the development of pathologies. The likelihood of progression or regression can be influenced by other determinants, but these processes will nevertheless occur in the absence of such influences. The distributional characteristics of the model approximate the findings of epidemiological studies indicating that, for both caries and periodontitis, there will be few sites affected in the early period after the eruption of the permanent dentition, but in those older there is an almost linear relationship with increasing age; furthermore, the longer a site survives without being affected, the less likely that it will be affected. We discuss the clinical and public health importance of these findings.

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Section: The Core Microbiomementioning

confidence: 99%

Section: The Core Microbiomementioning

confidence: 99%

Caries and Periodontitis: Contesting the Conventional Wisdom on Their Aetiology

Manji¹,

Dahlén

Fejerskov

2018

Caries Res

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“…[35][36][37][38] In health, the child's oral flora has a variety of VGS, Neisseria species, Haemophilus species, and Staphylococcus species. In older children, species responsible for periodontal diseases (eg, Capnocytophaga) can be found along with others known to cause IE (eg, Aggregatibacter actinomycetemcomitans).…”

Section: Pathogenesis Of Ie On Prosthetic Materialsmentioning

confidence: 99%

Infective Endocarditis in Childhood: 2015 Update

Baltimore¹,

Gewitz²,

Baddour³

et al. 2015

Circulation

313

238

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“…For an individual, birth is a borderline between the sterile intrauterine life and the extrauterine existence with a continous exposure to microorganisms (Kononen, 1999). The microbial community is further shaped by diet, personal oral hygiene (Crielaard et al, 2011) and other parameters such as hormones and various systemic conditions.…”

Section: Gingivitis Associated With Hormonal Changesmentioning

confidence: 99%