Oral colonization is unlikely to play an important role in Helicobacter pylori infection

Oshowo, A; Tunio, Mutahir A.; Gillam, DG; Botha, A; Holton, John; Boulos, PB; Hobsley, M

doi:10.1046/j.1365-2168.1998.00724.x

Cited by 55 publications

(39 citation statements)

References 8 publications

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“…This study investigated only adult patients. As H. pylori infection is mainly acquired in childhood [33], and the number of H. pylori in the mouths of adults is very low, this does not seem to be a signi®cant risk for hosts themselves [34,35]. According to a recent study, it seems likely that an infected mother may play a key role in transmission of H. pylori to her child, possibly via saliva [36].…”

Section: Discussionmentioning

confidence: 99%

Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR

Song¹,

Lange

Spahr

et al. 2000

Journal of Medical Microbiology

155

142

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The precise mode of transmission and the natural reservoir for Helicobacter pylori are unknown. PCR assays have proved to be highly sensitive and speci®c and are regarded as the method of choice for detecting H. pylori DNA in the oral cavity. The aim of this study was to investigate the prevalence and distribution of H. pylori in the oral cavity. Forty-two patients undergoing gastroscopy were investigated for the presence of H. pylori in dental plaque and saliva by nested PCR, and in the stomach by the 13 C-urea breath test. Samples tested comprised dental plaque from molars, premolars and incisors and saliva. Two sets of primers homologous to the 860-bp fragment of H. pylori DNA, which have been shown previously to be highly sensitive and speci®c, were used for nested PCR. Eleven patients (26.2%) were infected with H. pylori in the stomach. H. pylori DNA was identi®ed in dental plaque samples from 41 patients (97%) and in 23 saliva samples (55%). The prevalence in dental plaque from molars, premolars and incisors was 82%, 64% and 59%, with an odds ratio of 3.18, 1.24 and 1 (reference), respectively. In conclusion, H. pylori was present in the oral cavity of 97% of tested patients, with a characteristic distribution that was independent of the infection status of the stomach. Thus H. pylori may belong to the normal oral micro¯ora.

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Section: Discussionmentioning

confidence: 99%

Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR

Song¹,

Lange

Spahr

et al. 2000

Journal of Medical Microbiology

155

142

View full text Add to dashboard Cite

show abstract

“…However, it is a fact that H. pylori has been detected in various dental samples, and there have been reports that paired strains from the mouth and stomach were identical (7,9). Oshowo et al (7) reported that oral colonization was a rare event, but did occur.…”

Section: Methodsmentioning

confidence: 99%

“…Today, it is considered to be a pathogen important to the development of gastrointestinal ulcers and it has been implicated as a carcinogen for gastric cancer and mucosa-associated lymphoid-tissue lymphoma of the stomach (2,3). H. pylori has been detected in dental plaque, saliva, and the subgingival region (4)(5)(6)(7)(8), and there have been reports that H. pylori strains in the mouth and stomach are identical (7,9,10). It has been suggested that the oral cavity might be an alternative reservoir for H. pylori (11,12).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori in oral ulcerations.

Shimoyama

Horie

Kato

et al. 2000

Journal of Oral Science

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Abstract:Helicobacter pylori is an important pathogen involved in the development of gastrointestinal ulcers, but its involvement in oral ulcerous lesions is unclear. As culture is generally recognized as the gold standard for diagnosis of H. pylori infection, we employed this approach to assess the association of H.pylori with oral mucosal ulcerations. Samples were collected from patients with oral mucosal ulcerative disorders: 12 cases of recurrent aphthous stomatitis (RAS), 7 cases of herpes simplex virus (HSV) stomatitis, and 3 cases of erosive lichen planus (LP). Serum IgG antibodies against H. pylori were examined in all cases. All of the RAS and erosive LP cases were culturenegative for H. pylori, while two cases of HSV stomatitis were positive. The two culture-positive cases were also seropositve for the H. pylori antigen. It is suggested that H. pylori might not have a direct association with oral ulcerations. However, H. pylori in the oral cavity might exist in a non-culturable coccoid state without productive infection, and might form colonies only under special conditions such as HSV infection. (J. Oral Sci. 42, 225-229 , 2000)

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“…4 Human stomach is not the only reservoir of H. pylori and it has been detected in dental plaques, oral lesions, and saliva. 5 Recently, some researchers stated that H. pylori could play a role in the pathogenesis of various otorhinolaryngologic problems. It has been investigated in tonsils, adenoids, paranasal sinuses and in the middle ears of patients with chronic otitis media.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter pylori colonisation in tonsillar tissue in cases of chronic tonsillitis: a prospective study

Sreejaraj

Sumam

Nevil

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Human stomach is not the only reservoir of Helicobacter pylori but it has been detected in dental plaques, oral lesions and saliva. It could play role in the pathogenesis of various otorhinolaryngologic problems and remains debatable. This study was aimed to find out the prevalence of H. pylori in tonsillar tissue of patients with chronic tonsillitis by rapid urease test in a tertiary hospital in Kerala.Methods: Prospective cross sectional study was done in patients who attended the outpatient department of ENT with a history suggestive of chronic tonsillitis. The patient satisfied the criteria for chronic recurrent tonsillitis were subsequently posted for tonsillectomy. Each specimen was subjected to rapid urease test. Results: Total 228 patients were included in this study with age ranging between 3 and 31 years (10.0±7.1), with most common age being <10 years in 159 patients (69.7%). Male to female ratio was 1.4:1. Among these, the presence of H. pylori was seen in only 6/228 patients.Conclusions: The possibility of tonsillar tissue acting as a reservoir for H. pylori infection is very low.

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Oral colonization is unlikely to play an important role in Helicobacter pylori infection

Abstract: Oral colonization is a rare event, but does occur. Its rarity suggests that it is not an important factor in reinfection.

Cited by 55 publications

References 8 publications

Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR

Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR

Helicobacter pylori in oral ulcerations.

Prevalence of Helicobacter pylori colonisation in tonsillar tissue in cases of chronic tonsillitis: a prospective study

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