Oral Contraception and Breast Diseases

Carbonaro, A.; Ciotta, L; Stracquadanio, Mariagrazia; Formuso, C.; Giunta, M R; Agati, A. D.; Leanza, Vito; Giannone, Tania; Chammas, Mayada; Chammas, F; Pafumi, C; Zarbo, Giuseppe

doi:10.11648/j.ajns.20120101.11

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…Study of Carbonaro concluded the same as earlier clinical trials, that in women who used hormonal contraceptive preparations there was no development of new benign breast changes nor worsening of preexisting, so the neutral effect was shown. However, there was a mastodynia reduction in patients who used OC for 36 months [35]. In our study, use of progesterone local therapy for 6 months showed no solid benign or malignant thickening, which was in accordance with the above mentioned research.…”

Section: Discussionsupporting

confidence: 91%

The Influence of Progesterone Gel Therapy in the Treatment of Fibrocystic Breast Disease

Brkic¹,

Vujović²,

Ivanisevic³

et al. 2016

OJOG

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The effect of progesterone therapy on E2/P ratio changes during the luteal phase, and its consequences are on mastalgia and cyst, within a fibrocystic breast disease (FBD). Fifty women with FBD were included. Information for mastalgia and mastodynia were checked with a questionnaire. All women had (E2) and (P) concentration checked before and during the therapy on the 21st and 24th day of a cycle, ultrasound measured size and number of cysts before and during the therapy. T-test, X 2-test, McNemar test, Wilcoxon test and Friedman test were used for statistics. There was a decrease E2/P relation during the therapy vs. before the treatment p < 0.01, as well as the decrease of E2 level on the 24th day during the therapy vs. same day of E2 level, before the therapy (p = 0.164). There was an increase of p level on the 24th day vs. on 24th day before the therapy (p < 0.001). During the therapy, it was found decrease in pain and tension (p < 0.001), and the number and size of the cysts (p < 0.001). Mastalgia and mastodynia significantly decreased during the local p gel therapy, and there was a significantly lower number and size of the cysts in patients with FBD.

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Section: Discussionsupporting

confidence: 91%

The Influence of Progesterone Gel Therapy in the Treatment of Fibrocystic Breast Disease

Brkic¹,

Vujović²,

Ivanisevic³

et al. 2016

OJOG

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“…This study showed the majority of patients suffering from benign breast tumors do not use oral contraceptives, which is as much as 75.5%. This is in line with Carbonaro (10) that said there is no significant difference between users of oral contraceptives and non-users of oral contraceptives for the incidence of benign breast disease. But this study differs from Sihombing's study (8) which states that oral contraceptives increase the risk of breast tumors and Yu's study (9) in which oral contraceptives increase the risk of fibroadenoma.…”

Section: Discussionsupporting

confidence: 89%

“…Sihombing (8) said that contraceptive pill users have a 3.63 times risk greater for breast tumors compared to noncontraceptive pill users as well as Yu (9) said that oral contraceptive use causes the increased risk for fibroadenoma. While Carbonaro (10) said there is no significant difference between users of oral contraceptives and non-users of oral contraceptives for the incidence of benign breast disease. This is an important situation to study because oral contraception is a method that mostly used by Indonesian women as much as 2,261,480 women in 2013 (11) .…”

Section: Introductionmentioning

confidence: 99%

Oral Contraception Use in Benign Breast Tumor Patients in Dr. Soetomo General Academic Hospital

Putri

Mustokoweni

Ernawati

2019

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The growth of breast tumors is influenced by estrogen and progesterone hormones. One source of this hormone is hormonal contraception, including oral contraception which still in demand by Indonesian women. This study wants to identify oral contraception use in patients with benign breast tumors. This used descriptive study with a retrospective cross-sectional design. Samples were taken using the total sampling method in patients with benign breast tumors according to ICD 10 D-24 which was confirmed by FNAB examination at the POSA Dr. Soetomo General Academic Hospital between 2015-2017. Fifty three case of benign breast tumor were found with dominant characteristics at the age of group 40-49 years old (47.2%), had a breastfeeding history (50.9%), multiparous woman(64.2%), mean of menarche age at 13.28 years old and fertile periode women (83.0%). The most common type of benign tumors found were fibrocystic change. Patients who used oral contraceptives were 24.5% with an average length of use for 8 years 2 months, while another 75.5% used non-hormonal contraception or did not use any contraception. So the conclusion is majority of patients with benign breast tumors do not use oral contraception. Keywords: benign breast tumor; oral contraception; estrogen

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“…16 In this study, most of the BBL was found in OCP non users which is in contrast with recent study by A. Carbonaro et al who showed no direct relationship between OCP and BBL. 17 Fibroadenoma and fibrocystic disease of breast was more common in nullipara. Other studies showed increased incidence of fibrocystic disease with nulliparity but no relation of nulliparity with fibroadenoma.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of benign breast lumps, is it changing: a prospective study

Kumar

Prasad

2019

Int Surg J

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Background: There are wide range of benign breast diseases reported from India. Breast lumps are one of the commonest presentations. Although most of the breast lumps are benign but patient become anxious due to fear of malignancy. Due to this, there is an increase in the use of screening mammography and the fine needle aspiration cytology (FNAC) or core needle biopsy (CNB), most of which yield benign findings. This study is aimed to evaluate the incidence of different types of benign breast lumps in respect to age, size, side and site, relation with parity and use of oral contraceptive pills and analyses of this result in relation with the past and recent study on benign breast diseases.Methods: This study was conducted at Rajendra Institute of Medical Sciences, Ranchi (India) over a period of one and half years. Inclusion criteria was the cases with palpable breast lumps which were reported benign on either FNAC or CNB and exclusion criteria was the cases with breast malignancy and inflammatory breast lumps.Results: Most common benign breast lump (BBL) was fibroadenoma followed by fibrocystic disease of breast. Fibroadenoma was mainly presented with lump only whereas fibrocystic diseases of breast presented with lump and pain. Most of the BBL was found in nullipara and OCP non-users.Conclusions: Epidemiology of BBL is still the same when analyzed with past and recent study on the benign breast diseases. Triple assessment remains the key in the evaluation of breast lumps.

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Oral Contraception and Breast Diseases

Cited by 4 publications

References 11 publications

The Influence of Progesterone Gel Therapy in the Treatment of Fibrocystic Breast Disease

The Influence of Progesterone Gel Therapy in the Treatment of Fibrocystic Breast Disease

Oral Contraception Use in Benign Breast Tumor Patients in Dr. Soetomo General Academic Hospital

Epidemiology of benign breast lumps, is it changing: a prospective study

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