Oral contraception and the risk of hepatocellular carcinoma

Maheshwari, Shail; Sarraj, Amrou; Kramer, Jennifer; El–Serag, Hashem B.

doi:10.1016/j.jhep.2007.03.015

Cited by 109 publications

(48 citation statements)

References 22 publications

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“…However, in populations with high prevalence of hepatitis virus infection, no significant relationship was found (WHO, 1989;Kew et al, 1990). A recent metaanalysis of 12 case-control studies indicated no association between short term OC use and risk of HCC, but the author did mention the possibility of a causal relationship in non-hepatitis B endemic areas with long-term OC use (Maheshwari et al, 2007).…”

Section: Oral Contraceptivesmentioning

confidence: 99%

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Gao¹,

Xie²,

Yang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

128

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Section: Oral Contraceptivesmentioning

confidence: 99%

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Gao¹,

Xie²,

Yang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

128

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“…However, they do not provide information on the prognosis of the tumour. 5 A disintegrin and metalloproteinase (ADAM)10 belongs to the disintegrin and metalloproteinase (ADAM) gene family. This family is a class of type I transmembrane proteins that participate in a wide range of physiological functions.…”

Section: Introductionmentioning

confidence: 99%

A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression

Zhang

Liu

et al. 2014

J Int Med Res

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Objective: A disintegrin and metalloprotease (ADAM)10 has been implicated in the progression of various solid tumours. Little is known, however, about its role in hepatocellular carcinoma (HCC). The aim of the present study was to evaluate the protein and transcript level expression of ADAM10 in HCC patients. Methods: Samples of HCC and adjacent noncancerous liver tissue were taken during liver resection surgery. Immunostaining was used to measure ADAM10 protein expression levels and quantitative reverse-transcription polymerase chain reaction was used to measure ADAM10 mRNA expression levels. Levels of ADAM10 were compared, and a survival analysis undertaken. Results: In total, 98 HCC patient samples were studied. There were significant associations between protein levels of ADAM10 and tumour grade, amount of tumour differentiation, tumour size and the presence of metastasis. Furthermore, ADAM10 protein expression was significantly associated with shortened patient survival. Conclusions: ADAM10 is strongly expressed in a large proportion of HCC cases, which is in agreement with findings in other tumour entities. Expression of ADAM10 may serve as a useful molecular marker for HCC.

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“…There is also accumulating evidence that OC use may decrease the risk of colorectal cancer. 5,12,13 In contrast, OC use has been associated with a borderline significantly increased risk of hepatocellular carcinoma (HCC) 14 and a significantly increased risk of cervical cancer in a pooled analysis. 15 It is speculated that OC use is only a cofactor in the presence of human papillomavirus (HPV).…”

Section: Introductionmentioning

confidence: 99%

Oral Contraceptive Use Among Women in the Military and the General U.S. Population

Enewold¹,

Brinton

McGlynn

et al. 2010

Journal of Women's Health

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Objective: To compare oral contraceptive (OC) use during a 12-month period among women aged 18-39 years in the U.S. military and the general U.S. population using data from the Military Health System Management Analysis and Reporting Tool (M2) and the National Health and Nutrition Examination Survey (NHANES), respectively. Methods: OC use was age adjusted to the 2000 U.S. Census population. Comparisons between the military (n ¼ 83,181) and the general population (unweighted n ¼ 360), as well as between the military branches, were conducted overall and stratified by age, race=ethnicity, and marital status. Results: OC use was higher in the military (34%) than in the general population (29%, p < 0.05). This difference increased with age and was most pronounced among Hispanics (military, 32.2%; general population, 19.8%). Within the military, OC use was highest in the Air Force (39%) and lowest in the Army (30%, p < 0.05). Conclusions: These findings suggest that OC use differs between the military and the general population and within the military by service branch. Further studies that assess whether OC use is related to variations in health outcomes between these two populations and within the military are warranted.

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Oral contraception and the risk of hepatocellular carcinoma

Cited by 109 publications

References 22 publications

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression

Oral Contraceptive Use Among Women in the Military and the General U.S. Population

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