Oral Contraception and Venous Thrombosis

Hormone replacement therapy and venous thromboembolism

“…Concern about the relationship between the use of hormonal therapies and venous thromboembolism (VTE), including deep venous thrombosis (DVT), pulmonary embolism (PE) and less commonly cerebral venous thrombosis (CVT), was first raised 5 decades ago in women taking oral contraceptives (OC) [1]. Evidence quickly demonstrated a definitive correlation between not only OC and VTE but also demonstrated a strong positive correlation between OC dose and VTE risk [2].…”

Hormonal Steroid Contraceptives1 III

“…The possible association received publicity in the United States because of 2 deaths in Los Angeles within 1 week in 1961 from idiopathic pulmonary embolism in young women on oral contraceptives (Tyler, 1963). Since then, hundreds of cases of thrombo-embolic phenomena of various kinds have been reported in the literature, and there have been thousands of reports to adverse drug reactions organisations in the countries in which these are functioning.…”

A Review of Hormonal Contraception and Venous Thromboembolism in Adolescents

“…8 Relative HC-associated VTE risk is highest in the first year of use, and particularly in the first six months. This risk does not increase with continued HC use.…”