2013
DOI: 10.1016/j.psyneuen.2012.11.006
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Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive

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Cited by 127 publications
(111 citation statements)
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“…We found that women who had changed a hormonal contraceptive method because of a decrease in sexual desire had about an eightfold increased odds of considering stopping or changing their hormonal contraceptive method again, which is consistent with earlier findings 25 . Recall bias must, however, be considered and the calculated OR should be interpreted with some caution.…”
Section: Similarities and Differencessupporting
confidence: 91%
See 1 more Smart Citation
“…We found that women who had changed a hormonal contraceptive method because of a decrease in sexual desire had about an eightfold increased odds of considering stopping or changing their hormonal contraceptive method again, which is consistent with earlier findings 25 . Recall bias must, however, be considered and the calculated OR should be interpreted with some caution.…”
Section: Similarities and Differencessupporting
confidence: 91%
“…Half of the 13 women who used the LNG-IUS and reported reduced sexual desire had experienced the same adverse effect earlier with another hormonal contraceptive method. In a small randomised clinical trial, Gingnell et al 25 showed that women with subjective reports of previous COC-induced mood deterioration displayed depressed mood and mood swings when re-exposed to COCs.…”
Section: Similarities and Differencesmentioning
confidence: 99%
“…In the study by Nyberg (22) with the aim of improving the physical and mood symptoms in women using third generation OCPs, results showed that the level of negative mood reduced and positive mood increased 3 months after taking 250 mg norgestimat and 35 mg ethinyl estradiol. Another study reported that in women taking second generation of oral contraceptives, mood swings, depression and fatigue was higher than the control group receiving placebo (23) and other studies have also reported that the level of negative mood increased in second generation oral contraceptives consumers (24-26). …”
Section: Discussionmentioning
confidence: 93%
“…T deficiency in women has been associated with a broad range of undesired effects [3,4], some of which, including mood disturbances and interference with sexual function, have been reported as side effects of COCs [5][6][7][8]. Normalizing total T and other androgen levels in women using a COC may be achieved by the co-administration of the natural human adrenal androgen dehydroepiandrosterone (DHEA), because it is orally bioavailable [9] and partially metabolized into T [10][11][12].…”
Section: Introductionmentioning
confidence: 99%