Oral Contraceptives and Breast Cancer Risk Overall and by Molecular Subtype Among Young Women

Beaber, Elisabeth F.; Malone, Kathleen E.; Tang, Mei Tzu C; Barlow, William E.; Porter, Peggy L.; Daling, Janet R.; Li, Christopher I.

doi:10.1158/1055-9965.epi-13-0944

Cited by 72 publications

(91 citation statements)

References 49 publications

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“…In addition, in our study, the oral contraceptive use demonstrated a protective action, different from what has been described in the literature (30,31).…”

Section: Discussioncontrasting

confidence: 99%

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease

Conceição¹,

Dias²,

Pessoa³

et al. 2017

Nutr Hosp

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Introduction: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle.Objectives: Evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγpolymorphism.Material and Methods: A hospital-based case-control study was conducted including incident cases (n = 38 breast cancer; n = 75 benign breast disease; n = 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed.Results: No differences were observed for fatty acids intake. Interestingly, lauric acid (P = 0.001), myristic acid (P = 0.036), stearic acid (P = 0.031), and total saturated fatty acids (SFAs) (P=0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (P = 0.022), erucic acid (P = 0.002), total monounsaturated fatty acids (MUFAs) (P = 0.039) and oleic acid/stearic acid ratio (P = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (P = 0.977). The age at first full pregnancy (P = 0.004) was significantly associated with the development BC, whereas BMI (P = 0.005); percentage of body fat (P = 0.024); physical activity (P = 0.036); and age at menarche (P = 0.008), at first full pregnancy (P < 0.001), and of first mammogram (P = 0.018) were significantly associated with the development of BBD.Conclusion: The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC.

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“…In addition, in our study, the oral contraceptive use demonstrated a protective action, different from what has been described in the literature (30,31).…”

Section: Discussioncontrasting

confidence: 99%

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease

Conceição¹,

Dias²,

Pessoa³

et al. 2017

Nutr Hosp

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show abstract

“…This observation is in agreement with other works reporting the increased risk of breast cancer among women who consume oral contraceptive [47], [48]. Our observation suggests that the hormonal status and the genico-obstetric history of patients are important to direct miRs expression as potential prognostic biomarkers to predict some clinical features.…”

Section: Discussionsupporting

confidence: 93%

MicroRNAs Expression in Triple Negative vs Non Triple Negative Breast Cancer in Tunisia: Interaction with Clinical Outcome

et al. 2014

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IntroductionMicroRNAs are small, non coding regulatory molecules containing approximately 21 to 25 nucleotides. They function as controllers of expression at post transcriptional levels of most human protein-coding genes and play an essential role in cell signaling pathways. The objective of the present study is to evaluate the expression profile of the following micro-RNAs: miR-10b, miR-17, miR-21, miR-34a, miR-146a, miR-148a and miR-182, and to determine their possible interaction in triple-negative and non triple-negative primary breast cancers based on clinical outcome.Methods60 triple-negative and non triple-negative breast cancer cases, along with their corresponding normal samples were investigated in relation to the expression of the seven studied miRNAs using qPCR Syber Green.ResultsWe observed that miR-21, miR-146a and miR-182 were significantly over expressed in triple negative breast cancer. Moreover, miR-10b, miR-21 and miR-182 were significantly associated to lymph node metastases occurrence in triple negative breast carcinoma while only miR-10b was associated with grade III in non triple negative breast cancer cases. Almost all the analyzed microRNAs were strongly associated with patients’ genico-obstetric history in non triple negative breast cancer cases except for miR-34a. All the studied microRNAs were strongly correlated with the use of the contraceptive pills in non triple negative breast cancer groups. The additive effect of hormonal factors in triple negative breast cancer cases showed an association with all the studied miRs except for miR-34 and miR-146a.ConclusionThe studied microRNAs are strongly influenced by environmental factors especially with hormonal patients’ history. Moreover, miR-10b, miR-21 and miR-182 could be defined as biomarkers in breast cancer to predict both lymph node metastases and grade III occurrence.

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“…Indeed, Dolle et al (20), Beaber et al (18) and Kwan et al (23) reported that OC use increases the risk of TNBC; however, Marchbanks et al (29), Kawai et al (25) and Kabat et al (22) did not confirm this association.…”

Section: Discussionmentioning

confidence: 98%

Association between oral contraceptive use as a risk factor and triple-negative breast cancer: A systematic review and meta-analysis

Zhang

et al. 2017

Molecular and Clinical Oncology

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Abstract. Triple-negative breast cancer (TNBC), a unique subtype of breast cancer, which is resistant to endocrine and targeted therapy, usually relapses early, progresses rapidly and is associated with a poor prognosis. Epidemiological investigations focusing on the association between risk factors and the onset of TNBC demonstrated that the incidence of TNBC exhibits a significant correlation with anthropometric, geographical and demographic parameters. The aim of the present systematic review and meta-analysis was to evaluate the strength of the association between the use of oral contraceptives (OCs) and TNBC. Two databases (PubMed Central/PubMed, Web of Science) and secondary references were searched to identify studies meeting the priorly established inclusion criteria. Case-control studies published between January, 2005 and March, 2016 were searched using the key words (triple-negative breast cancer OR basal-like) AND (oral contraceptives). Finally, 9 eligible articles using as control other subtypes of invasive breast cancer and 7 articles using a healthy population as control were incorporated in the meta-analysis. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed-or random-effects models according to the heterogeneity between studies. The case-control comparison using other subtypes of breast cancer as the control arm exhibited a significant association between OC use and TNBC (OR = 1.31, 95% CI = 1.18-1.45; Z=5.26, P<0.00001). These results were further confirmed by the case-control comparison using the healthy population as the control arm (OR = 1.21, 95% CI = 1.01-1.46; Z=2.04, P=0.04). The present meta-analysis indicated that women who use OCs have a greater risk of TNBC compared with women who do not. This conclusion prompts that women who used OCs should be examined more closely in population screenings of breast cancer, as they may benefit from prevention and early detection strategies.

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Oral Contraceptives and Breast Cancer Risk Overall and by Molecular Subtype Among Young Women

Cited by 72 publications

References 49 publications

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease

MicroRNAs Expression in Triple Negative vs Non Triple Negative Breast Cancer in Tunisia: Interaction with Clinical Outcome

Association between oral contraceptive use as a risk factor and triple-negative breast cancer: A systematic review and meta-analysis

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