Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis

Chapron, Charles; Souza, Carlos Augusto Bastos de; Borghese, Bruno; Lafay-Pillet, Marie-Christine; Santulli, Piétro; Bijaoui, G; Goffinet, François; Ziegler, Dominique de

doi:10.1093/humrep/der156

Cited by 135 publications

(103 citation statements)

References 43 publications

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“…For this purpose, we confronted various characteristics of OC use and the surgical diagnosis of endometriosis, histologically graded as superficial, ovarian endometrioma, or DIE. 21 In 410 patients with histologically proven endometriosis, we confirmed the association between past OC users and endometriosis (OR: 2.79, 95% CI: 1.74, 5.12; P 5 .002). This association was observed for all rAFS * classifications.…”

Section: Oral Contraceptives Prescribed For Adolescent Dysmenorrheasupporting

confidence: 66%

Markers of Adult Endometriosis Detectable in Adolescence

Chapron

Borghese

Streuli

et al. 2011

Journal of Pediatric and Adolescent Gynecology

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Section: Oral Contraceptives Prescribed For Adolescent Dysmenorrheasupporting

confidence: 66%

Markers of Adult Endometriosis Detectable in Adolescence

Chapron

Borghese

Streuli

et al. 2011

Journal of Pediatric and Adolescent Gynecology

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“…44 Other studies were small including a total of 512-976 women with 168-410 endometriosis cases. 10,12 This study also has limitations, which should be considered. It is a cross-sectional study where information was collected at one time point with no follow-up, which probably affected the prevalence of endometriosis.…”

Section: Strength and Weaknessesmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11] A link between use of oral contraceptives (OCs) and endometriosis is still uncertain. Researchers have observed an increased risk, 12 a protective effect, 13 and even no association 14 between OC and endometriosis. It has been suggested that up to 50% of infertile women have endometriosis; however, a causal link has not yet been demonstrated.…”

mentioning

confidence: 99%

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Saha

Kuja‐Halkola

Tornvall

et al. 2017

Journal of Women's Health

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Objectives: Despite the high prevalence of endometriosis among women of reproductive age, risk factors or markers for developing the condition remain largely unknown. Many of the published studies are based on small selected samples. We therefore investigated the relationships of reproductive and lifestyle factors with endometriosis in a large sample of Swedish female twins. Material and methods: This cross-sectional study included 28,822 women. Among these, endometriosis was reported by 1,228 women and the self-reported diagnosis was confirmed by medical records. Potential risk factors or markers for risk considered were age at menarche, level of education, body mass index (BMI), parity, oral contraceptive (OC) use, infertility, coffee consumption, smoking, and alcohol intake, which were investigated using logistic regression with crude and adjusted analyses. We performed within-pair analysis to examine the sensitivity of the results. Results: Late age at menarche and higher parity showed an inverse association and infertility showed a strong association with endometriosis. We observed positive associations with coffee consumption and smoking and an inverse association with OC use in crude analysis but not in adjusted analysis. There were no significant associations between level of education, BMI, or alcohol intake and endometriosis. Within-pair analysis showed persistent inverse association of parity and association of infertility with endometriosis. Conclusions: Our study suggests that late age at menarche and higher parity are inversely associated and infertility is strongly associated with endometriosis. Future studies are needed to explore the significance of these factors in the diagnosis of endometriosis and understanding of its etiology.

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“…The best way of diagnosis is laparoscopy or laparotomy, along a histological confirmation of macrophages with hemosiderin, endometrial epithelium and endometrial glands or stroma. Malignant transformation has been observed in 0, 6 presented ovaric endometriosis. GnRH analogues are broadly used as medical treatment, while danazol is less used because of its androgenic effects.…”

Section: Endometriosis In the Inguinal Channel: A Casementioning

confidence: 99%

“…Chapron et al, realizó un estudio transversal de 566 pacientes con diagnóstico quirúrgico de endometriosis ovárica, peritoneal e infiltrante profunda; para evaluar si estaba asociado a anticonceptivos orales. Concluyeron que las pacientes que usaban anticonceptivos orales por dismenorrea asociaban principalmente endometriosis profunda infiltrativa, cabe destacar que aclaran que no significa que los anticonceptivos orales aumenten el riesgo d endometriosis [6]. Por otro lado, el uso cíclico de anticonceptivos orales monofásicos puede ayudar en el manejo de la endometriosis.…”

Section: Definición Y Epidemiologíaunclassified

Endometriosis en El Canal Inguinal: Reporte De Caso

Alpízar

González

2013

Rev.Med.UCR

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Resumen: Endometriosis se define como la presencia de tejido glandular y estromal endometrial fuera de la cavidad uterina y este tejido ectópico es dependiente de la estimulación estrogénica. Usua en ovarios, fondos de saco, ligamento ancho, ligamento uterosacro, útero, trompas de Falopio, tracto gastrointestinal y geniturinario. Sin embargo, puede inguinal. Prevalece en 10% de las mujeres en edad reproductiva. Existen muchos factores contribuyentes a esta patología como la herencia, edad, anomalías anatómicas del sistema reproductor femenino, paridad, alteraciones del ciclo menstrual, uso de anticonceptivos orales, factores am hay muchas teorías descritas entre estas la menstruación retrógrada que podría explicar la etiología del caso que se describe en este artículo. El síntoma más frecuente es el dolor pélv infertilidad. El diagnóstico de elección se realiza mediante laparoscopía o laparotomía, acompañado de confirmación histológica de macrófagos con hemosiderina, epitelio endometrial y glándulas o estroma endometrial. Se ha observado transformación maligna en 0.6 endometriosis ovárica. Dentro del tratamiento médico usados, mientras que se utiliza menos anticonceptivos orales se aplica cuando las pacientes asocian mucho dolor pélvico. El tratamiento quirúrgico consiste en la ablación del tejido endometrial ectópico a través de laparoscopia. Endometriosis se define como la presencia de tejido glandular y estromal endometrial fuera de la cavidad uterina y este tejido ectópico es dependiente de la estimulación estrogénica. Usua en ovarios, fondos de saco, ligamento ancho, ligamento uterosacro, útero, trompas de Falopio, tracto gastrointestinal y geniturinario. Sin embargo, puede presentarse en otras localizaciones, como en el canal las mujeres en edad reproductiva. Existen muchos factores contribuyentes a esta patología como la herencia, edad, anomalías anatómicas del sistema reproductor femenino, paridad, alteraciones del ciclo menstrual, uso de anticonceptivos orales, factores ambientales. Fisiopatoló hay muchas teorías descritas entre estas la menstruación retrógrada que podría explicar la etiología del caso que se describe en este artículo. El síntoma más frecuente es el dolor pélvico y se ha asociado también la lidad. El diagnóstico de elección se realiza mediante laparoscopía o laparotomía, acompañado de confirmación histológica de macrófagos con hemosiderina, epitelio endometrial y glándulas o estroma endometrial. Se ha observado transformación maligna en 0.6-0.8% de las mujeres que presentaron endometriosis ovárica. Dentro del tratamiento médico los análogos de la hormona GNRH son se utiliza menos el danazol por sus efectos androgénicos, el uso combinado de AINES y cuando las pacientes asocian mucho dolor pélvico. El tratamiento quirúrgico consiste en la ablación del tejido endometrial ectópico a través de laparoscopia. ENDOMETRIOSIS EN EL CANAL INGUINAL: REPORTE DEUniversidad de Costa Rica, San Pedro, San José, Endometriosis se define como la presencia de tejido glandular y estromal endometrial fuera ...

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Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis

Cited by 135 publications

References 43 publications

Markers of Adult Endometriosis Detectable in Adolescence

Markers of Adult Endometriosis Detectable in Adolescence

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Endometriosis en El Canal Inguinal: Reporte De Caso

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