Oral contraceptives, cigarette smoking and other factors in relation to arthritis

Vessey, Martin; Villard-Mackintosh, L; Yeates, D

doi:10.1016/0010-7824(87)90082-5

Cited by 209 publications

(117 citation statements)

References 5 publications

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“…We do find a significant association between smoking and risk of RA, as has been shown by multiple other studies (4)(5)(6)(7)(8)(9)(10)(11). An important distinction between the present study and previous analyses of coffee and tea is our ability to update information on both beverage intake and potential confounders; we do not assume that the initial information reported at baseline remains unchanged over time.…”

Section: Discussionsupporting

confidence: 57%

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Coffee consumption and risk of rheumatoid arthritis

Karlson¹,

Mandl²,

Aweh³

et al. 2003

Arthritis & Rheumatism

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Objective. Recent reports have suggested an association between consumption of coffee or decaffeinated coffee and the risk of rheumatoid arthritis (RA), although data are sparse and somewhat inconsistent. Furthermore, existing studies measured dietary exposures and potential confounders only at baseline and did not consider possible changes in diet or lifestyle over the followup period. We studied whether coffee, decaffeinated coffee, total coffee, tea, or overall caffeine consumption was associated with the risk of RA, using the Nurses' Health Study, a longitudinal cohort study of 121,701 women.Methods. Information on beverage consumption was assessed with a food frequency questionnaire (FFQ) that was completed every 4 years, from baseline in 1980 through 1998. Among the 83,124 women who completed the FFQ at baseline, the diagnosis of incident RA (between 1980 and 2000) was confirmed in 480 women by a connective tissue disease screening questionnaire and medical record review for American College of Rheumatology criteria. Relationships between intake of various beverages and the risk of RA were assessed in age-adjusted models and in multivariate Cox proportional hazards models including the cumulative average intake of each beverage during the followup period, adjusted for numerous potential confounders. In addition, for direct comparisons with prior reports, multivariate analyses were repeated using only baseline beverage information.Results. We did not find a significant association between decaffeinated coffee consumption of >4 cups/ day (compared with no decaffeinated coffee consumption) and subsequent risk of incident RA, in either an adjusted multivariate model (relative risk [RR] 1.1, 95% confidence interval [95% CI] 0.5-2.2) or a multivariate model using only baseline reports of decaffeinated coffee consumption (RR 1.0, 95% CI 0.6-1.7). Similarly, there was no relationship between cumulative caffeinated coffee consumption and RA risk (RR 1.1, 95% CI 0.8-1.6 for >4 cups per day versus none) or between tea consumption and RA risk (RR 1.1, 95% CI 0.7-1.8 for >3 cups/day versus none). Total coffee and total caffeine consumption were also not associated with the risk of RA.Conclusion. In this large, prospective study, we find little evidence of an association between coffee, decaffeinated coffee, or tea consumption and the risk of RA among women.

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Section: Discussionsupporting

confidence: 57%

“…RA (4)(5)(6)(7)(8)(9)(10)(11) and coffee consumption (12). Thus, because in the existing studies information on confounders such as smoking has not been updated, there is a possibility for residual confounding and a bias away from the null hypothesis if coffee drinkers are more or less likely to quit smoking than are non-coffee drinkers.…”

mentioning

confidence: 99%

Coffee consumption and risk of rheumatoid arthritis

Karlson¹,

Mandl²,

Aweh³

et al. 2003

Arthritis & Rheumatism

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“…The majority of previous studies did not find any significant association between BMI and RA overall (11)(12)(13)(14)(15). The most vital difference between these studies and the current study is that we looked at RA in the 2 major subsets and not only in RA overall.…”

Section: Discussionmentioning

confidence: 65%

Association between body mass index and anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis: Results from a population‐based case–control study

Wesley¹,

Bengtsson²,

Elkan³

et al. 2012

Arthritis Care & Research

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Objective. Being overweight or obese is associated with many chronic diseases, but previous studies of the association with rheumatoid arthritis (RA) have shown inconsistent results. The aim of this study was to investigate the association between body mass index (BMI) and the risk of developing the 2 main subtypes of RA. Methods. At inclusion, cases and controls answered questions about their weight and height and donated blood samples. The presence of antibodies to citrullinated protein antigens (ACPAs) was analyzed among 2,748 cases and 3,444 controls (28% men). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using conditional logistic regression. Results. Compared to those with normal weight (BMI <25 kg/m 2 ), the adjusted overall OR for developing ACPA-negative RA was 1.1 (95% CI 0.9 -1.3) for overweight individuals (BMI >25 to <30 kg/m 2 ) and 1.4 (95% CI 1.1-1.9) for obese individuals (BMI >30 kg/m 2 ). When stratified by sex, the OR for ACPA-negative RA for obese women was 1.6 (95% CI 1.2-2.2), and there was no association between obesity and ACPA-negative RA in men (OR 1.1, 95% CI 0.6 -1.8). In obese men compared to men with normal weight, the OR for ACPA-positive RA was 0.6 (95% CI 0.3-0.9), while there was no association between BMI and ACPA-positive RA among women (OR 1.0, 95% CI 0.8 -1.2). Conclusion. Our findings show that obesity is associated with developing ACPA-negative RA in women, and indicate an inverse association between BMI and ACPA-positive RA in men.

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“…The association of smoking with development and severity of RA was documented almost 30 years ago [10] and confirmed in many subsequent studies [11][12][13][14][15][16][17][18][19][20][21]. A recent dose-response meta-analysis (encompassing 4,552 RA patients) reported relative risks of 1.26 and 1.96 for the associations of RA with smoking histories of 1-10 and >20 pack years respectively [19].…”

Section: Smoking and Ramentioning

confidence: 77%

Smoking and Air Pollution as Pro-Inflammatory Triggers for the Development of Rheumatoid Arthritis

Anderson

Meyer

Ally

et al. 2016

NICTOB

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Smoking is now well recognised not only as a risk factor for rheumatoid arthritis (RA), but also as a determinant of disease activity, severity, response to therapy, and possibly mortality. Recent studies have provided significant insights into the molecular and cellular mechanisms which underpin the pathogenesis of smokingrelated RA. These involve release of the enzymes, peptidylarginine deiminases (PADs) 2 and 4 from smoke-activated, resident and infiltrating pulmonary phagocytes. PADs, in turn, mediate the conversion of various endogenous proteins to putative citrullinated autoantigens. In genetically susceptible individuals, these autoantigens trigger the production of anti-citrullinated peptide/protein pathogenic autoantibodies (ACPA), an event which precedes the development of RA. This review is focused primarily on smoking-mediated harmful chronic inflammatory responses, both local and systemic, which promote the formation of ACPA, as well as the possible involvement of other types of outdoor and indoor pollution in the pathogenesis of RA. This is preceded by a brief overview of the evidence implicating smoking as a risk factor for development of ACPA-positive RA.Keywords: Anti-citrullinated peptide/protein antibodies; airway microbiota; atmospheric pollution; heavy metals; peptidylarginine deiminases; smoking cessation strategies. ImplicationsChronic inflammatory mechanisms operative in the lungs of smokers lead to the production of anti-citrullinated protein antibodies which, in turn, drive the development of rheumatoid arthritis. These mechanistic insights not only reinforce the association between smoking and risk for rheumatoid arthritis, but also the necessity to increase the level of awareness in those at highest risk.

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Oral contraceptives, cigarette smoking and other factors in relation to arthritis

Cited by 209 publications

References 5 publications

Coffee consumption and risk of rheumatoid arthritis

Coffee consumption and risk of rheumatoid arthritis

Association between body mass index and anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis: Results from a population‐based case–control study

Smoking and Air Pollution as Pro-Inflammatory Triggers for the Development of Rheumatoid Arthritis

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