Oral Contraceptives, Pyridoxine, and Depression

Winston, Frank

doi:10.1176/ajp.130.11.1217

Cited by 54 publications

(7 citation statements)

References 47 publications

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“…Depression is among the many reported premenstrual symptoms [46,47]. It has also been suggested that use of oral contraceptives worsens depressive symptoms [13,[48][49][50]. We found that dietary intake of vitamin B 6 was more strongly associated with depressive symptoms in an older cohort than total intake or plasma PLP.…”

Section: Discussionmentioning

confidence: 45%

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Vitamin B₆Is Associated with Depressive Symptomatology in Massachusetts Elders

Merete

Falcón

Tucker

2008

Journal of the American College of Nutrition

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Objective-We examined the cross-sectional relationship between dietary vitamin B 6 and plasma pyridoxyl-5′-phosphate concentrations (PLP) with depressive symptomatology among a representative sample of 618 elderly Caribbean Hispanics, and a neighborhood based comparison group of 251 non-Hispanic white (NHW) older adults in Massachusetts.Methods-Depressive symptomatology was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). 41% of Hispanics and 22.6% of NHWs had CES-D scores greater than 16, indicating depressive caseness. Dietary intake was calculated from a semi-quantitative food frequency questionnaire (FFQ) designed for this population.Results-PLP was significantly associated with CES-D score and depressive caseness in the total sample and in non-supplement users. Deficient levels of plasma PLP (plasma PLP < 20 nmol/L) approximately doubled the likelihood of depressive caseness. Total intake (diet + supplement) of vitamin B 6 was not associated with these outcomes. However, dietary vitamin B 6 was significantly associated with CES-D score and depressive caseness.Conclusion-Longitudinal studies are needed to clarify the direction of causality between vitamin B 6 and depressive symptoms.

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Section: Discussionmentioning

confidence: 45%

“…PLP is a necessary cofactor in decarboxylation reactions in tryptophan metabolism, which result in the conversion to the monoamine neurotransmitter, serotonin [13]. Regulation of mood, specifically depression, is highly dependent on tryptophan metabolism and serotonin production.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B₆Is Associated with Depressive Symptomatology in Massachusetts Elders

Merete

Falcón

Tucker

2008

Journal of the American College of Nutrition

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“…50 51 The combined odds ratio of the four trials (representing 541 patients) that presented data for depressive symptoms was 1.69 (1.39 to 2.06), and this was homogeneous. This indicates that vitamin B-6 is better than placebo in treating premenstrual depression.…”

Section: Discussionmentioning

confidence: 98%

Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review

Wyatt

Dimmock

Jones

et al. 1999

BMJ

239

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Objective To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects Nine published trials representing 940 patients with premenstrual syndrome. Main outcome measures Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo. Results Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients. Conclusion Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.

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“…Examples of other effects of pyridoxine not covered in this review include the interactions of pyridoxine with oral contraceptives (167), the antagonism of quinidine-induced atrial contractions (168), and the antagonism of penicillamine used in the treatment of Wilson's disease (169).…”

Section: Pyridoxinementioning

confidence: 99%