Oral Controlled Release‐Based Products for Life Cycle Management

Davar, Nipun; Ghosh, Sangita

doi:10.1002/9780470640487.ch18

Cited by 4 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these, Seroquelis unique in formulation as it employs a sustained release technology for once-a-day delivery of quetiapine. Quite often, sustained release versions of drug formulations are developed for product lifecycle management[1]. Thus, the sustained release technology is important to make existing drugs more effective.…”

Section: Drugs and Drug Delivery Systemsmentioning

confidence: 99%

Controlled Drug Delivery: Historical perspective for the next generation

Yun

Lee

Park

2015

Journal of Controlled Release

302

155

View full text Add to dashboard Cite

The modern day drug delivery technology is only 60 years old. During this period numerous drug delivery systems have been developed. The first generation (1950–1980) has been very productive in developing many oral and transdermal controlled release formulations for clinical applications. On the other hand, the second generation (1980–2010) has not been as successful in generating clinical products. This is in large part due to the nature of the problems to overcome. The first generation of drug delivery technologies dealt with physicochemical problems, while the second struggled with biological barriers. Controlled drug delivery systems can be made with controllable physicochemical properties, but they cannot overcome the biological barriers. The third generation (from 2010) drug delivery systems need to overcome both physicochemical and biological barriers. The physicochemical problems stem from poor water solubility of drugs, large molecular weight of peptide and protein drugs, and difficulty of controlling drug release kinetics. The biological barriers to overcome include distribution of drug delivery systems by the body rather than by formulation properties, limiting delivery to a specific target in the body. In addition, the body's reaction to formulations limits their functions in vivo. The prosperous future of drug delivery systems depends on whether new delivery systems can overcome limits set by human physiology, and the development process can be accelerated with new ways of thinking.

show abstract

Section: Drugs and Drug Delivery Systemsmentioning

confidence: 99%

Controlled Drug Delivery: Historical perspective for the next generation

Yun

Lee

Park

2015

Journal of Controlled Release

302

155

View full text Add to dashboard Cite

show abstract

“…CR formulations also provide increased duration of drug therapeutic effect [Wen and Park, 2010; Jayanthi et al 2011; Moodley et al 2012]. For pharmaceutical companies, CR formulations mean having exclusivity on the market, financial gains and in some cases drug patent life extension [Davar and Ghosh, 2010].…”

Section: Advantages and Disadvantages Of Using Controlled-release Medmentioning

confidence: 99%

Curse of the ghost pills: the role of oral controlled-release formulations in the passage of empty intact shells in faeces. Two case reports and a literature review relevant to psychiatry

Tungaraza

Talapan-Manikoth

Jenkins

2013

Therapeutic Advances in Drug Safety

View full text Add to dashboard Cite

Orally taken tablets in different formulations continue to have a central role in the treatment of various psychiatric and medical conditions. In order to improve compliance, reduce the frequency of taking medications and minimize the peaks and troughs associated with certain immediate-release formulations, pharmaceutical companies have developed a number of novel methods of delivering oral solid dosage medications in the form of controlled-release (CR) formulations. Some CR formulations have been associated with pharmacobezoars and false-positive findings on certain physical investigations. Though CR drugs are commonly used in psychiatry, clinicians appear to have a limited understanding of how they are released for absorption once ingested. Some have insoluble parts that are excreted in faeces as 'ghost pills'. Due to lack of awareness of this phenomenon to both patients and the physicians, anxiety has ensued in some patients. Some clinicians have been puzzled or have been dismissive when faced with curious patients wanting to know more after they had observed tablet-like looking structures in faeces. We present two cases from our clinical setting and a few drawn from the World Wide Web to highlight the role of CR medications and their association with the ghost pill phenomenon. The mechanisms involved in drug release relevant to psychiatry medications are also briefly reviewed. The ghost pill phenomenon occurs with certain CR medications. This is a normal and expected outcome related to drug-release mechanisms of some of these products. It is inevitable that some patients will see what looks like tablets or capsules in faeces. Raising awareness of this phenomenon among clinicians would facilitate discussions and information sharing at the initial process of medication prescribing. Awareness among patients and carers would also help to allay anxiety.

show abstract

Antihypertensives’ Rock around the Clock

Rahić

Tucak

Sirbubalo

et al. 2021

View full text Add to dashboard Cite

Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.

show abstract

Oral Controlled Release‐Based Products for Life Cycle Management

Cited by 4 publications

References 27 publications

Controlled Drug Delivery: Historical perspective for the next generation

Controlled Drug Delivery: Historical perspective for the next generation

Curse of the ghost pills: the role of oral controlled-release formulations in the passage of empty intact shells in faeces. Two case reports and a literature review relevant to psychiatry

Antihypertensives’ Rock around the Clock

Contact Info

Product

Resources

About