Oral Corticosteroid Use in Asthma: A Wolf in Sheep's Clothing

Fuhlbrigge, Anne L.; Sharma, Sunita

doi:10.1016/j.jaip.2020.10.014

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Nevertheless, the frequency of these incidents continues to increase, highlighting the ongoing need to address the burden of disease, particularly among school-aged children (Asher et al 2021 ). The primary approach to managing asthma includes the use of short-acting β(2)-agonist (SABA) medications and inhaled corticosteroids (Fuhlbrigge and Sharma 2021 ; Nwaru et al 2020 ). These treatments are intended to prevent or minimize asthma symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…These treatments are intended to prevent or minimize asthma symptoms. However, it is important to note that the use of these medications has been associated with certain adverse effects, such as an increased likelihood of exacerbations and even higher mortality rates (Fuhlbrigge and Sharma 2021 ; Nwaru et al 2020 ). The pathophysiology of asthma encompasses inflammation, hyperresponsiveness, and airway remodeling.…”

Section: Introductionmentioning

confidence: 99%

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CDC167 exhibits potential as a biomarker for airway inflammation in asthma

Zhong,

Wu,

Cai

et al. 2024

Mamm Genome

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Current asthma treatments have been discovered to decrease the risk of disease progression. Herein, we aimed to characterize novel potential therapeutic targets for asthma. Differentially expressed genes (DEGs) for GSE64913 and GSE137268 datasets were characterized. Weighted correlation network analysis (WGCNA) was used to identify trait-related module genes within the GSE67472 dataset. The intersection of the module genes of interest, as well as the DEGs, comprised the key module genes that underwent additional candidate gene screening using machine learning. In addition, a bioinformatics-based approach was used to analyze the relative expression levels, diagnostic values, and reverently enriched pathways of the screened candidate genes. Furthermore, the candidate genes were silenced in asthmatic mice, and the inflammation and lung injury in the mice were validated. A total of 1710 DEGs were characterized in GSE64913 and GSE137268 for asthma patients. WGCNA identified 2367 asthma module genes, of which 285 overlapped with 1710 DEGs. Four candidate genes, CDC167, POSTN, SEC14L1, and SERPINB2, were validated using the intersection genes of three machine learning algorithms, including Least Absolute Shrinkage and Selection Operator, Random Forest, and Support Vector Machine. All the candidate genes were significantly upregulated in asthma patients and demonstrated diagnostic utility for asthma. Furthermore, silencing CDC167 reduced the levels of inflammatory cytokines significantly and alleviated lung injury in ovalbumin (OVA)-induced asthmatic mice. Our study demonstrated that CDC167 exhibits potential as diagnostic markers and therapeutic targets for asthma patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CDC167 exhibits potential as a biomarker for airway inflammation in asthma

Zhong,

Wu,

Cai

et al. 2024

Mamm Genome

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“…Airway inflammation is considered to be an important factor in causing BA. Therefore, controlling airway inflammation is important to treating BA 4 . Research has suggested that airway smooth muscle (ASM) responses play an important role in BA and that ASM contraction (ASMC) leads to bronchoconstriction 5 .…”

Section: Introductionmentioning

confidence: 99%

Yanghe Pingchuan granules mitigates oxidative stress and inflammation in a bronchial asthma rat model: role of the IKK/IκB/NF-κB signalling pathway

Pan,

Gong,

Chen

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Bronchial asthma (BA) is a chronic inflammatory airway disease. Previous research has shown that Yanghe Pingchuan granules (YPG), among the granules formulated by the First Affiliated Hospital of the Anhui University of Chinese Medicine, exerts a precise therapeutic effect on BA. We previously showed that YPG improves airway inflammation in BA rats. Other studies have shown that the inhibitor of kappa B kinase (IKK)/inhibitor of NF-κB (IκB)/nuclear factor kappa-B (NF-κB) signaling pathway plays a key role in inflammation mediation. Therefore, this study explored whether YPG could intervene in BA through the IKK/IκB/NF-κB signaling pathway. Methods: Ovalbumin-induced method was used to established BA rat model. After successful modeling, we used YPG to intervene the rats in BA rats. Hematoxylin-eosin (HE) staining was used to detect the bronchial pathological changes in BA rats, enzyme linked immunosorbent assay (ELISA) was used to detect the changes of inflammatory factors (IL-1β and IL-6) and oxidative stress indexes malondialdehyde (MDA), superoxide dismutase (SOD) and nitrogen monoxide (NO), Quantitative real-time PCR and Western-blot were used to detect the expression of IKK/IκB/NF-κB signaling pathway. Results: In BA model rats, YPG significantly improved the inflammatory response in bronchial tissues, reduced inflammatory factors IL-1β and IL-6, alleviated oxidative stress, reduced MDA and NO, and increased SOD. Quantitative real-time PCR and Western-blot results showed that YPG could block the IKK/IκB/NF-κB signaling pathway. Conclusion: These findings showed that YPG had a definite therapeutic effect on BA, which may be related to blocking the IKK/IκB/NF-κB signaling pathway and improving inflammation and oxidative stress.

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“…10 A more consistent threshold for cumulative OCS to initiate biologic therapy in patients with T2-high asthma and develop additional glucocorticoid-sparing strategies is needed. 11 It is equally important to recognize comorbid conditions and appropriately treat them for optimal asthma outcomes.…”

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confidence: 99%