Oral Crohn′s disease without intestinal manifestations

Harikishan, G; Reddy, Nagate Raghavendra; Prasad, Harikrishnan; Anitha, S

doi:10.4103/0975-7406.100322

Cited by 21 publications

(16 citation statements)

References 10 publications

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“…These findings may be associated with pain, impairment of oral function, and psychosocial stress ( 9 ). Other non-specific oral findings of CD include angular cheilitis, persistent submandibular lymphadenopathy, gingivitis, and pe-riodontal disease ( 4 , 11 ).…”

Section: Discussionmentioning

confidence: 99%

Oral manifestations as the first presenting sign of Crohn's disease in a pediatric patient

et al. 2017

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Crohn’s disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal (GI) tract. Although the GI tract is the primary site of involvement, many patients, particularly in pediatric cases, first present with non-intestinal manifestations, including oral lesions. Oral manifestations of CD in children occur in around 50-80% of cases, and about 30% of CD cases in children occur first in the mouth. Recognizing such oral lesions in the pediatric population, and requesting a biopsy, may expedite the diagnosis of CD. We describe a 15 year old male who presented with oral findings of multiple aphthous ulcers and plaques of pink papules of the buccal vestibule. We highlight the initial pathology findings, including non-caseating granulomas, sialadenitis, and a notable plasmacytosis, from biopsy of the left retromolar pad area, which triggered further testing for CD. We provide discussion of how CD was eventually diagnosed and treated and highlight the significance of the pathological findings in this case as they relate to the pathogenesis of CD. Key words:Crohn’s disease, Inflammatory bowel disease, Oral manifestations, Pediatric, Granulomatous inflammation, Monotypic plasma cells.

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Section: Discussionmentioning

confidence: 99%

Oral manifestations as the first presenting sign of Crohn's disease in a pediatric patient

et al. 2017

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“…The whole gingiva, up to the mucogingival line, might be involved. The gingiva may become edematous, granular and hyperplastic with or without ulceration [ 19 , 20 ]. Other specific lesions are deep swelling with vertical fissures and deep linear ulceration.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Orofacial Granulomatosis: Clinical Signs of Different Pathologies

et al. 2015

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Orofacial granulomatosis (OFG) is an uncommon disease characterized by persistent or recurrent soft tissue enlargement, oral ulceration and a variety of other orofacial features. It could be an oral manifestation of a systemic disease. For a correct differential diagnosis, local and systemic conditions characterized by granulomatous inflammation should be excluded using appropriate clinical and laboratory investigations. In fact, the diagnosis of OFG may be confirmed only by histopathological identification of noncaseating granulomas. The literature from 1943 to 2014 was reviewed with emphasis on the etiology of OFG and on clinical manifestations of systemic pathologies associated with OFG. The precise cause of OFG is still unknown, although several theories have been suggested, such as infection, hereditary factors and allergy. OFG is a disease that has a wide spectrum of presentation, which may include the oral manifestation of a systemic condition such as Crohn's disease, sarcoidosis, granulomatosis with polyangiitis and Melkersson-Rosenthal syndrome.

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“…3 In rare cases, oral manifestations may be the initial and/or only presentation of disease. 4 Histologically, Crohn's disease presents with non-necrotizing granulomatous inflammation. Differential diagnosis includes sarcoidosis, foreign body reaction, and infections such as tuberculosis, cat-scratch disease, histoplasmosis, etc.…”

Section: Case Reportmentioning

confidence: 99%