Oral delivery and enhanced efficacy of antimonal drug through macrophage-guided multifunctional nanocargoes against visceral Leishmaniasis

Sarwar, Hafiz Shoaib; Sohail, Muhammad; Sarwar, M.; Akhtar, Sohail; Satoskar, Abhay R.; Shahnaz, Gul

doi:10.1016/j.ejpb.2020.05.029

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…The Glucantime (Glu)-loaded thiolated nanocarriers (Glu-Thi-CHI) improved penetration into the intestinal barrier in comparison to the same dose of oral Glu. The increased hepatic and serum concentration of stibogluconate after Glu-Thi-CHI treatment reduced the hepatic and splenic parasite burden more efficiently than the standard intraperitoneal treatment (Shoaib Sarwar et al, 2020). Considering the renal toxicity caused by Glu, Cosco et al developed biocompatible Glu-loaded aqueous-core polylactic acid (PLA) nanocapsules in an attempt to reduce kidney t o x i c i t y .…”

Section: Leishmaniasismentioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment.

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Section: Leishmaniasismentioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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“…In the direct method, metal-NPs kill the parasitic cells by causing vacuolation inside parasites and damage to the cellular membrane without generating immunomodulatory intermediaries, that is, reactive oxygen species (ROS), nitric oxide (NO), and apoptotic and necrotic factors (Fanti et al, 2018). In situations when Leishmania parasites override the oxidative burst inside phagocytic cells and reside in phagolysosomes, nanoformulations assist site-specific delivery and accumulation of drugs, which is responsible for parasite killing (Shoaib Sarwar et al, 2020). According to Fanti et al (2018), Ag-NPs after diffusion through the cellular membranes get oxidized due to acidic conditions within the phagolysosomes, and eventually, the release of free Ag + ions causes parasite assassination.…”

Section: Restorative Mechanism Of Nanoformulations Against Leishmaniasismentioning

confidence: 99%

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

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The present review focuses on a dreaded vector-mediated leishmaniasis, with the existing therapeutic approaches including a variety of drugs along with their limitations, the treatment with natural compounds, and different types of metal/metal oxide nanoparticles (NPs). As evidenced, various metallic NPs, comprising silver, silver oxide, gold, zinc oxide, titanium, lead oxide, etc., played a curative role to treat leishmaniasis, are also presented. Keeping in view the advance success of vaccines against the prevalent dreaded diseases in the past and the present scenario, efforts are also being made to develop vaccines based on these NP formulations.

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Nanomedicines for the Treatment of Veterinary Parasitic Infections

Surve,

Bhide,

Jindal

et al. 2023

AAPS Advances in the Pharmaceutical Sciences Series

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Oral delivery and enhanced efficacy of antimonal drug through macrophage-guided multifunctional nanocargoes against visceral Leishmaniasis

Cited by 10 publications

References 21 publications

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Nanomedicines for the Treatment of Veterinary Parasitic Infections

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