Oral Delivery of Silver Nanoparticles – A Review

Joshi, Vedamurthy; Sulthana, Firdos; Ramadas, Dinesha

doi:10.22159/ajpcr.2021.v14i11.42986

Cited by 3 publications

(2 citation statements)

References 62 publications

(64 reference statements)

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“…Nanoparticles of metallic materials are used in biological imaging and targeted drug delivery because of their excellent optical, magnetic, and photo thermal properties. Several types of metal nanoparticles are commonly used, including silver [102], copper, iron and gold nanoparticles. In intracellular drug delivery, gold nanoparticles are used due to their size and surface properties [103].…”

Section: Metallic Nanoparticlementioning

confidence: 99%

A Review of Nanoparticle Innovations in Cancer Therapy: Implications, Targeting Mechanisms and Clinical Prospects

R.,

VELMURUGAN

2024

Int J App Pharm

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The main reason for morbidity and death globally is cancer, which has a complex pathophysiology. There are several traditional treatments for cancer, including chemotherapy, radiation therapy, targeted therapies, and immunotherapies. Multiple drug resistance, cytotoxicity, and lack of specificity pose significant challenges to cancer treatments. Molecular diagnostics and cancer treatment have been transformed by nanotechnology. For cancer treatment, nanoparticles (1–100 nm) are ideal because they are biocompatible, have low toxicity, excellent stability, high permeability, are precise and stable, and can deliver clear and accurate results. There are several main categories of nanoparticles. When it comes to the delivery of nanoparticle drugs, tumour characteristics and the tumour environment are considered. As well as providing advantages over conventional cancer treatments, nanoparticles prevent multidrug resistance, further overcoming their limitations. As new mechanisms are unravelled in studying multidrug resistance, nanoparticles are becoming more critical. Nano formulations have gained a new perspective on cancer treatment due to their many therapeutic applications. The number of approved nanodrugs has not increased significantly despite most research being conducted in vivo and in vitro. A review of nanoparticle oncological implications, targeting mechanisms, and approved nanotherapeutics is presented here. A current perspective on clinical translation is also provided, highlighting its advantages and challenges.

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Section: Metallic Nanoparticlementioning

confidence: 99%

A Review of Nanoparticle Innovations in Cancer Therapy: Implications, Targeting Mechanisms and Clinical Prospects

R.,

VELMURUGAN

2024

Int J App Pharm

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“…Oral drug administration has got several benefits over other routes of administration. This route is non-invasive, safer, and comfortable, do not require a skilled person to administer, and dose adjustments can be tailor-made to suit the individual patient and hence it is most patient compliant [1]. The recent advance in nanotechnology has led to the development of a targeted drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Ceritinib Loaded Nanobubbles by Box-Behnken Design

MURALIKRISHNA

BABU²,

MAMATHA³

2022

Int J App Pharm

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Objective: Ceritinib is an anaplastic lymphoma kinase (ALK) inhibitor used to treat lung cancer. In the current research, the ceritinib-loaded nanobubbles were prepared by using perfluorobutane for inner core and medium molecular weight chitosan for the shell. Methods: A 33Box-Behnken design was used to determine the influence of L-α-Phosphatidylcholine (A), the concentration of chitosan (B) and concentration of palmitic acid (C) factors affecting particle size, and polydispersity index. The individual effects of these factors on particle size and polydispersity index were depicted in perturbation plot, response surfaces and counterplots based on Derringer’s desirability approach. Results: The extreme desirability function value was obtained at A: 1.31 % w/v, B: 3.00 % w/v, C: 1.5 % W/V. Three batches of formulation were prepared in accordance to the desirability function and evaluated. TEM images revealed the superficial morphology and core-shell structure of nanobubbles in the size range of 150-200 nm. Nanobubbles were able to load ceritinib with an encapsulation efficiency of 79.12 % and a loading capacity of 19.2 %. The nanobubbles released about 95.67 % drug in 24h. The in vitro cellular uptake study results show the enhanced cellular uptake of ceritinib with ultrasound from nanobubbles. In vitro cytotoxicity study results indicated that ultrasound-assisted nanobubbles can effectively release in the cells with high sensitivity. Conclusion: Chitosan-based ceritinib nanobubbles, therefore, offer a remarkable tool for the development of ultrasound-responsive formulations that deliver drugs to the target.

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Clinical translation of silver nanoparticles into the market

Younis

2024

Silver Nanoparticles for Drug Delivery

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Oral Delivery of Silver Nanoparticles – A Review

Cited by 3 publications

References 62 publications

A Review of Nanoparticle Innovations in Cancer Therapy: Implications, Targeting Mechanisms and Clinical Prospects

A Review of Nanoparticle Innovations in Cancer Therapy: Implications, Targeting Mechanisms and Clinical Prospects

Formulation and Optimization of Ceritinib Loaded Nanobubbles by Box-Behnken Design

Clinical translation of silver nanoparticles into the market

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