Oral Desensitization and Induction of Tolerance in Peanut-Allergic Children

Oral immunotherapy for the treatment of peanut allergy: systematic review of six case series studies

“…Three full-text articles and three abstracts relating to a total of six studies satisfied our inclusion criteria and were therefore included in this review (see the PRISMA flow diagram in Figure 1 and Table 1). [29][30][31][32][33][34] We also found several ongoing studies that had not yet reported on any of the outcomes of interest ( Table 2).…”

“…[29][30][31][32][33][34] The duration of maintenance treatment and the follow-up period varied considerably between studies, ranging from 6 PRIMARY CARE RESPIRATORY JOURNAL www.thepcrj.org days 31 to 36 months. 29 One study described the minimum length of the study period (i.e.…”

“…29 One study described the minimum length of the study period (i.e. 4 days) but did not mention the maximum duration of therapy .32 Four studies 29,[32][33][34] were multicentre, one of which was conducted in a private office-based setting. 32 The two other studies were based in a single centre.…”

“…32 The two other studies were based in a single centre. 30,31 Four of the studies were conducted in the USA, 29,[32][33][34] one in the UK, 30 and one in Germany. 31 …”

“…The study by Wasserman et al 32 differed in that the inclusion criterion was either a clinical history of peanut allergy or objective evidence of peanut sensitisation; also relevant is that this report relates to OIT being administered to patients with a range of food allergies so, in keeping with the focus of this review, we have concentrated solely on the data on patients with peanut allergy. Three studies 31,32,34 included participants who were judged to have severe peanut allergy and consequently were at high risk of subsequent anaphylactic reactions.…”