Oral dextrose gel to prevent hypoglycaemia in at-risk neonates

Roberts, Lily; Lin, Luling; Alsweiler, Jane; Edwards, Taygen; Liu, Gordon; Harding, Jane E

doi:10.1002/14651858.cd012152.pub4

Cited by 6 publications

(2 citation statements)

References 63 publications

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“…12 However, based on the Cochrane Review published in 2023 by Roberts et al, authors conclude that prophylactic administration of oral DG should not be incorporated into routine clinical practice until information from large follow-up studies looking at the neurological disabilities are available. 13 A retrospective population-based cohort study conducted by Kaiser et al showed that early transient newborn hypoglycemia was associated with lower achievement test scores at age 10 years. 14 Any reduction in the burden of hypoglycemia does, therefore, has the scope to produce signi cant bene ts on a population level.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Implementation of Oral Dextrose Gel on the Incidence of Multiple Hypoglycemia Events in the Well Newborn Nursery

Vaidyanathan,

Reid,

Yuan

et al. 2024

Preprint

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Objective: Evaluate the impact of 40% oral dextrose gel (DG) for management of neonatal hypoglycemia (NH) on the incidence of multiple hypoglycemic events in the well-baby nursery. Study Design: A retrospective chart review of 738 at-risk infants in 2 cohorts before (Cohort 1) and after (Cohort 2) DG implementation. Primary outcome was the incidence of ≥2 hypoglycemic episodes. Secondary outcomes were median number of hypoglycemia events per infant, lowest median glucose level, and incidence of NICU admission. Results: There were 384 and 354 at-risk newborns in Cohorts 1 & 2. Incidence of multiple hypoglycemia episodes decreased following DG implementation [62(42.5%) vs 29(25.9%), p=0.0058]. Median (range) number of hypoglycemic episodes per infant also decreased [1 (1-6) vs 1 (1-5), p=0.046]. There were no differences in lowest glucose level [37 (14-45) vs 37 (10-45), p=0.31] or NICU admission rate [31 (21.2%) vs 21 (18.8%), p=0.62]. Conclusions:Implementation of DG lowers the incidence of subsequent multiple hypoglycemia events.

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Section: Discussionmentioning

confidence: 99%

The Impact of Implementation of Oral Dextrose Gel on the Incidence of Multiple Hypoglycemia Events in the Well Newborn Nursery

Vaidyanathan,

Reid,

Yuan

et al. 2024

Preprint

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“…Review updates can have the same author composition as the previous version, although there are deviations (for example, see (19)(20)(21)(22)(23) and their previous versions). Also, in this study, the unit of analysis is a published paper and not a project.…”

Section: Data Sources and Retrievalmentioning

confidence: 99%

Geographical and Gender Diversity in Cochrane and non-Cochrane Reviews Authorship: A Meta-Research Study

Sofi-Mahmudi,

Stojanova,

Vounzoulaki

et al. 2024

Preprint

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Background: Cochrane is a recognized source of quality evidence that informs health-related decisions. As an organization, it represents a global network of diverse stakeholders. Cochrane's key organizational values include diversity and inclusion, to enable wide participation and promote access. However, the diversity of Cochrane review authorship has not been well summarized. Objective: The aim of this study was to examine the distribution of country, region, language, and gender diversity in the authorship of Cochrane reviews. Methods: We retrieved all published articles from the Cochrane Library (until November 6, 2023)-a web crawling technique that extracted pre-specified data fields, including publication date, review type, and author affiliations. We used E-utility calls to capture the data for non-Cochrane systematic reviews. We determined the country and region of affiliations and the gender of the first, corresponding, and last authors for Cochrane reviews, as well as the country and region of affiliations and the gender of the first authors for non-Cochrane reviews. Trends in geographical and gender diversity over time were evaluated using logistic regression. Fisher's exact test was used for comparisons. The diversity of first authors between Cochrane and non-Cochrane reviews was explored through visual presentation, Pearson's product-moment correlation, and the Granger Causality Test. We used R for data collection and analysis. Results: A total of 22681 citations were retrieved. The United Kingdom had the highest first-author representation (33.2%), followed by Australia (11.6%) and the United States (7.0%). We observed an increase in the proportion of first authors from non-English speaking countries, from 16.7% in 1996 to 42.8% in 2023. Female first authorship increased steadily, from 15.0% in 1996 to 55.6% in 2023. The proportion of first authors from lower-and-middle-income countries (LMICs) was highest in 2012 at 23.2%. Since then, it has decreased to 18.4% in 2023. Similarly, the proportion of last authors from LMICs decreased over time (25.0% in 1996 vs. 16.2% in 2023). Among review groups, Sexually Transmitted Infections and Consumers and Communication were the most and least diverse groups with 68.1% and 1.6% of first authors from LMICs, respectively. In terms of gender diversity, Fertility Regulation had the highest percentage of female first authors (72.1%). Urology (28.1%) had the lowest percentage of female first authors. In 2023, over half of the non-Cochrane reviews had first authors from non-English-speaking countries (n=14,589, 56.9%), 50.8% (n=13,014) had first authors from LMICs, and 42.3% (n=10,841) had female first authors. The Pearson's product-moment correlations between Cochrane and non-Cochrane reviews' trends were 0.265 (P=0.450) for LMICs, 0.823 (P<0.001) for non-English speaking, 0.634 (P<0.001) Spanish-speaking, and 0.829 (P<0.001) for female first authorship. Conclusion: Overall, this study found positive trends, with an increase in first authorship by individuals who were female and from non-English speaking countries. However, the representation of first authors from non-high-income countries decreased. Future research could further explore these trends, identifying potential barriers influencing access and participation of individuals and groups and assessing strategies that help promote diversity and inclusion.

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What are the effects of oral dextrose for preventing hypoglycemia in at-risk neonates?

Burch¹,

Tort²

2021

Cochrane Clinical Answers

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Oral dextrose gel to prevent hypoglycaemia in at-risk neonates

Cited by 6 publications

References 63 publications

The Impact of Implementation of Oral Dextrose Gel on the Incidence of Multiple Hypoglycemia Events in the Well Newborn Nursery

The Impact of Implementation of Oral Dextrose Gel on the Incidence of Multiple Hypoglycemia Events in the Well Newborn Nursery

Geographical and Gender Diversity in Cochrane and non-Cochrane Reviews Authorship: A Meta-Research Study

What are the effects of oral dextrose for preventing hypoglycemia in at-risk neonates?

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