Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries

Rivera, César; Jones-Herrera, Carolina; Vargas, Pablo Agustín; Venegas, Bernardo; Droguett, Daniel

doi:10.1101/134056

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Sua prevalência na mucosa da bochecha é de 39,2%, e na mucosa do lábio inferior, de 10,8%. Ou seja, trata-se de lesões hiperplásicas comuns da cavidade oral [16,23]. Fibromas são clinicamente vistos como crescimentos pedunculados ou sésseis, em qualquer região da mucosa, sendo em sua maioria pequenas lesões sem nenhum potencial maligno.…”

Section: Introductionunclassified

Conduta clínica e tratamento de duas lesões bucais em paciente diabética: relato de caso

Stroparo¹,

Oliveira²,

Kusma³

et al. 2021

RSBO

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Lesões hiperplásicas intraorais são de comum diagnóstico no dia a dia do cirurgião-dentista. Mesmo que pareçam inofensivas, podem apresentar potencial de malignidade, tornando necessários uma minuciosa anamnese e um bom exame clínico. Neste o profissional deve chegar à correta intervenção, na qual muitas vezes se faz preciso uma biópsia. Objetivo: Demonstrar a conduta clínica e o tratamento de duas lesões bucais em paciente diabética. Relato de caso: A paciente MNV, 59 anos, sexo feminino, diabética, procurou tratamento para doença periodontal. Durante o exame clínico, observaram-se duas lesões em mucosa jugal presentes havia mais de duas semanas. Foram solicitados os exames de sangue da paciente, os quais apresentaram valor de glicemia de 139 mg/dL.F e de hemoglobina glicada de 6,5%. Como essas lesões estavam presentes na cavidade bucal da paciente havia mais de duas semanas e por causa da sua dimensão, foram avaliados os riscos e benefícios do procedimento. Com isso, o tratamento proposto foram a biópsia excisional de ambas as lesões e o envio para análise histopatológica. Resultados: O resultado da análise da lesão da mucosa jugal do lado esquerdo, com 7 mm em seu maior diâmetro, foi fibroma oral com ausência de alterações citopáticas virais e/ou malignidade. Conforme análise da lesão da mucosa jugal do lado direito, com 2,5 mm em seu maior diâmetro, foi provável ectopia/grânulo de Fordyce com ausência de alterações citopáticas virais e/ou malignidade. Conclusão: A excisão das lesões, conforme a literatura, é indicada quando há indício de malignidade e/ou queixa do paciente que procura o cirurgião-dentista com a dúvida da lesão persistente. No caso descrito, não ocorreram recidivas no acompanhamento de 180 dias.

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Section: Introductionunclassified

Conduta clínica e tratamento de duas lesões bucais em paciente diabética: relato de caso

Stroparo¹,

Oliveira²,

Kusma³

et al. 2021

RSBO

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“…2 Usually it occurs in young healthy individuals, with a high frequency in the labial and buccal mucosa and tongue. 3 RAS occurs in three clinical presentations: minor, major, and herpetiform. 4 Several medical disorders are associated with ulcers.…”

Section: Introductionmentioning

confidence: 99%

Immune system and zinc are associated with recurrent aphthous stomatitis. An assessment using a network-based approach.

Rivera¹

2017

J Oral Res

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Objective: The aim of this research was to identify genes, proteins and processes from the biomedical information published on recurrent aphthous stomatitis (R AS) using network-based foci. Methods: The clinical context was defined using MeSH terms for R AS and biomarkers, combined with words associated with risk. A set of protein coding genes was prioritized using the Génie web server and classified with PANTHER. For defining biologically relevant proteins, protein-protein interaction networks were constructed using Reactome database and Cytoscape. Top 20 proteins were then subjected to functional enrichment using STRING. Results: From 1,075,576 gene-abstract links, 1,491 genes were prioritized. Proteins were related to signaling molecule proteins (n=221), receptor proteins (n=221) and nucleic acid binding proteins (n=169). The network constructed with these proteins included 3,963 nodes and functional analysis showed that main processes involved immune system and zinc ion binding function. Conclusions: For the first time, bioinformatics tools were used for integrating pathways and networks associated with R AS. Molecules and processes associated with immune system recur robustly in all analyzed information. The molecular zinc ion binding function could be an area for exploring more specific and effective therapeutic interventions.

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Bednar’s Aphthae in Infants in Duhok; A Prospective Cross-Sectional Study

Haleem,

Abdulrahman,

Atrushi

2022

JSMC

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Background Bednar’s aphthae are small shallow ulcers at the margin of the palate of newborns. They primarily result from the traumatic action of a bottle teat or the nipple of the mother’s breast during feeding. More recently, an immune process has been hypothesized to explain its pathogenesis. Objectives To study the clinical features, the associated factors, and the time of healing of Bednar’s aphthae in Duhok. Patients and Methods This study was conducted from January 1st, 2020, to February 1st, 2021. It enrolled 17 newborns and infants diagnosed with Bednar’s aphthae through clinical examination while undergoing routine health checkups. Information about sex, delivery mode, age, birth weight, gestational age, perinatal problems, feeding method, feeding habits, type of milk (formula, breast milk, or both), and using a pacifier or not were obtained from mothers through direct interviews. Through the use of a tongue depressor, the palate was visualized. In addition, parents were educated on how to posture the patient while feeding properly. Four weeks later, a follow-up visit was for the ulcers’ course follow-up. Results Male is the predominant gender. Vaginal delivery was the most common. All the participants were full-term with normal birth weights. The age at which diagnosis was made ranged from 14 to 60 days. Most of them were formula-fed. In 15 patients (88.23%), feeding was in a horizontal posture; 11 (64.7%%) had weak sucking, 10(58.82%) had prolonged feeding time, and 13(76.47%) used pacifiers. The location is marginal in 12 cases (70.58%). The shape was oval in 13 patients (76.47%), and the healing time ranged from 1 week to 4 weeks. The largest ulcer was 2x2 cm, and the smallest was 0.2x0.3 cm. Conclusion Bednar’s aphthae are self-limiting disorders in newborns and infants. Mechanical and immunologic factors can be responsible for their pathogenesis. Health education for mothers can help the healing of the ulcers and prevent their recurrence.

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Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries

Cited by 3 publications

References 26 publications

Conduta clínica e tratamento de duas lesões bucais em paciente diabética: relato de caso

Conduta clínica e tratamento de duas lesões bucais em paciente diabética: relato de caso

Immune system and zinc are associated with recurrent aphthous stomatitis. An assessment using a network-based approach.

Bednar’s Aphthae in Infants in Duhok; A Prospective Cross-Sectional Study

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