Oral disorders related to acromegaly

Belmehdi, Akram; Chbicheb, Saliha

doi:10.11604/pamj.2019.34.96.19873

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…The development of the midface, including the sella turcica and teeth, may be modified by disrupting signaling pathways due to mutations in the homeobox genes [ 7 ]. Moreover, glandular anomalies may be associated with functional disorders, e.g., altered hormonal levels, thus influencing dental development [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Sella Turcica Morphology on Cephalometric Radiographs and Dental Abnormalities—Is There Any Association?—Systematic Review

Jankowski

Jedliński

Grocholewicz

et al. 2021

IJERPH

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Background: The sella turcica is a saddle-like structure in the middle cranial fossa on the intracranial surface of the sphenoid bone, visible on lateral cephalograms routinely conducted for orthodontic diagnosis. The development of facial structures follows similar traits to the sella turcica: glandular anomalies may be associated with functional disorders, e.g., altered hormonal levels, thus influencing dental development. The aim of this study is to find out if there is any association between the morphology of the sella turcica on cephalometric radiographs and the presence of dental abnormalities. (2) Methods: The search was conducted on 27 January 2021 in four search engines: Medline (PubMed Central), Scopus, Web of Science, Embase. The keywords used in the search strategy were as follows: “sella turcica” AND (“dental abnormalities” OR “dental anomalies” OR “malocclusion”). Since all the studies finally included were retrospective case–control studies, the Newcastle–Ottawa Quality Assessment Form for Case–Control Studies was applied. (3) Results: The search strategy identified 465 articles: 289 from PubMed, 121 from Scopus, 32 from Web of Science and 23 from Embase. Finally, 10 full-text papers were included into qualitative analysis. (4) Conclusions: Sella turcica bridging is very frequent among orthodontic patients. A clear association exists between dental abnormalities and sella turcica bridging.

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Section: Introductionmentioning

confidence: 99%

Sella Turcica Morphology on Cephalometric Radiographs and Dental Abnormalities—Is There Any Association?—Systematic Review

Jankowski

Jedliński

Grocholewicz

et al. 2021

IJERPH

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“…One study described mild to moderate gingival ‘enlargement’ in 8 acromegalic patients out of 11 examined ( 8 ) but it was not reported if this term means thick gingival biotype or gingival hypertrophy and if periodontitis was associated. In the same way, although there is preclinical evidence of a trophic role of acromegaly on cementum ( 25 ) and two published cases reports mentioning radiological hypercementosis on molars of acromegalic patients ( 12 , 13 ), systematic orthopantomogram revealed only two cases of hypercementosis, each affecting only one tooth per patient. Hypercementosis could result from local factors such as a chronic periapical infection, lack of function due to unopposed teeth and trauma from abnormal dental occlusion ( 26 ).…”

Section: Discussionmentioning

confidence: 92%

“…A total score below 80 points, that is, 66% is considered as a clinically significant impact of acromegaly on patients' quality of life. This score can be divided into three dimensions: Physical Symptoms subscale (i.e., Items 1,3,9,[13][14][15]19, and 22), Appearance Issues subscale (i.e., Items 2,4,7,11,12,16,and 17), and Personal Relation Issues subscale ( Items 5,6,8,10,18,20 and 21). As for the global score, results for each dimension were scored on a 0 to 100 basis.…”

Section: Study Populationmentioning

confidence: 99%

“…Some observations describe a gingival enlargement in acromegalic patients (8), which is known to promote periodontal disease leading to tooth loss, while others suggest that acromegaly could protect against this frequent medical condition (9,10,11). Besides, two cases reports described hypercementosis (overgrowth of the cement) in an acromegalic patient (12,13) but the link with the disease remains questionable. Most importantly, the dental state and the impact of oral manifestations on the patient's quality of life are not reported at all in acromegaly.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study

Roumeau

Thevenon

Ouchchane

et al. 2020

Endocrine Connections

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Objective: The dental and periodondal impact of GH/IGF-1 hypersecretion has been poorly investigated until now. Our aim is to precisely describe the oro-dental state of acromegalic patients and to study the impact of GH/IGF-1 hypersecretion on patients' reported oral health related quality of life (OHRQoL). Methods: After collecting characteristics of their disease, acromegalic patients answered the GOHAI questionnaire assessing their OHRQoL, the AcroQoL questionnaire and then benefited from a complete stomatological and radiological examination (orthopantomogram systematically, retro-alveolar radiography or Cone Beam computed tomography if necessary). Results: 29 patients aged 59.1±16.0 years were included. The average DMFT index (sum of Decayed, Missing and Filled Teeth per patient) was 19.0±7.8. 16/29 patients had a gingivitis and 18/29 a mild to moderate chronic periodontitis, but no case of severe chronic periodontitis was found, probably because the frequency of a protective thick gingival biotype was increased (9/29). No case of generalized gingival hypertrophy or diffuse hyper-cementosis was observed. According to the Add-GOHAI score, only 8/26 patients had a satisfactory OHRQoL. This parameter was correlated to the acromegaly-specific quality of life according to the AcroQoL score. Interestingly, 11/29 patients had bulky oral bony outgrowths (OBO) such as large maxillary or mandibular tori and multiple vestibular exostosis. Conclusions: The unsatisfactory OHRQoL reported by acromegalic patients contrasts with a rather good objective oro-dental state and annual oral examination seems relevant in this population. Finally, we report that huge OBO could be helpful signposts for the diagnosis of acromegaly.

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Orofacial Manifestations of Systemic Diseases

Atkin

2024

Pathological Basis of Oral and Maxillofacial Diseases

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Oral disorders related to acromegaly

Cited by 4 publications

References 18 publications

Sella Turcica Morphology on Cephalometric Radiographs and Dental Abnormalities—Is There Any Association?—Systematic Review

Sella Turcica Morphology on Cephalometric Radiographs and Dental Abnormalities—Is There Any Association?—Systematic Review

Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study

Orofacial Manifestations of Systemic Diseases

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