Oral Docosahexaenoic Acid in the Prevention of Exudative Age-Related Macular Degeneration

Souied, Eric H.; Delcourt, Cécile; Bassols, Ana Margareth Siqueira; Merle, Bénédicte M. J.; Zourdani, A.; Smith, Theodore; Benlian, Pascale

doi:10.1016/j.ophtha.2013.01.005

Cited by 129 publications

(107 citation statements)

References 40 publications

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“…[37][38][39][40][41][42][95][96][97] Also, subgroup analysis from the Nutritional AMD Treatment 2 Study from 2013, revealed that high levels of n-3 PUFAs in red blood cells can prevent AMD progression. 98 To assess if antioxidants and n-3 PUFAs could induce additive effects, a second AREDS2 study was designed to evaluate if inclusion of n-3 PUFAs to the AREDS formulation further reduced the risk of progression to advanced AMD. However, no additional effect was observed in preventing AMD progression.…”

Section: Discussionmentioning

confidence: 99%

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

et al. 2015

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Section: Discussionmentioning

confidence: 99%

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

et al. 2015

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“…Also, no significant correlation was established for EPA+DHA supplementation with the progression of AMD (P = 0.74) (143). In contrast with the AREDS2 result, the Nutritional AMD Treatment-2 study, in which patients were administered 840 mg DHA/d and 270 mg EPA/d for 3 y, suggested that the CNV incidence was markedly reduced in DHA-supplemented patients (72).…”

Section: Introductionmentioning

confidence: 81%

The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration

Gorusupudi

Nelson

Bernstein

2017

Advances in Nutrition

101

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Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. With an increasingly aged population worldwide, the need for the prevention of AMD is rising. Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress-related retinal damage as an important contributing factor. In general, diet is an excellent source of the antioxidants, vitamins, and minerals necessary for healthy living; moreover, the general public is often receptive to recommendations made by physicians and health care workers regarding diet and supplements as a means of empowering themselves to avoid common and worrisome ailments such as AMD, which has made epidemiologists and clinicians enthusiastic about dietary intervention studies. A wide variety of nutrients, such as minerals, vitamins, v-3 (n-3) fatty acids, and various carotenoids, have been associated with reducing the risk of AMD. Initial results from the Age-Related Eye Disease Study (AREDS) indicated that supplementation with antioxidants (b-carotene and vitamins C and E) and zinc was associated with a reduced risk of AMD progression. The AREDS2 follow-up study, designed to improve upon the earlier formulation, tested the addition of lutein, zeaxanthin, and v-3 fatty acids. In this review, we examine the science behind the nutritional factors included in these interventional studies and the reasons for considering their inclusion to lower the rate of AMD progression. Adv Nutr 2017;8:40-53.

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“…Similarly, individuals with moderate to high risk of progression to late-stage AMD under-reporting high consumption of omega-3 long-chain PUFAs had a 30% lower incidence rate of neovascular AMD comparing to those individuals who reported a low dietary consumption of such FAs (Tan et al, 2009). The administration of a daily dose of EPA (350 mg) and DHA (650 mg) for 3 years has been shown to lower the risk of CNV in patients with early lesions of AMD, steadily achieving the highest tertile of omega-3 long-chain PUFAs in their red blood cell membranes (Souied et al, 2013). As long-term biomarkers of omega-3 long-chain PUFAs (Gorusupudi et al, 2016), red blood cell membranes with increased content of EPA and DHA (and plasma EPA) after dietary intake of seafoods are associated with a lower risk for neovascular AMD (Merle et al, 2014).…”

Section: Dietary Fatty Acids In Age-related Macular Degenerationmentioning

confidence: 97%

Dietary fatty acids and lipoproteins on progression of age-related macular degeneration

et al. 2017

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SUMMARY:Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management. This review summarizes the effects of dietary omega-3 long-chain PUFAs, MUFAs, and SFAs, and lipoproteins on AMD. Findings are consistent with the beneficial role of dietary omega-3 long-chain PUFAs, while the effects of dietary MUFAs and SFAs appeared to be ambiguous with respect to the possible protection from MUFAs and to the possible adverse impact from SFAs on AMD. Some of the pathological mechanisms associated with lipoproteins on AMD share those observed previously in cardiovascular diseases. It was also noticed that the effects of FAs in the diet and lipoprotein on AMD could be modulated by genetic variants. From a population health perspective, the findings of this review are in favour of omega-3 long-chain FAs recommendations in a preventive and therapeutic regimen to attain lower AMD occurrence and progression rates. Additional long-term and short-term nutrigenomic studies are required to clearly establish the role and the relevance of interaction of dietary FAs, lipoproteins, and genes in the genesis and progression of AMD. KEYWORDS: Age-related macular degeneration; Dietary fats; Fatty acids; Lipoproteins; Olive oil; RetinaRESUMEN: Efecto de los ácidos grasos y lipoproteínas de la dieta sobre la progresión de la degeneración macular relacionada con la edad. La degeneración macular asociada a la edad (DMAE) es una condición patológica caracterizada por pérdida de visión central y ceguera. Numerosos estudios han revelado que ciertos cambios en los ácidos grasos de la dieta podrían tener efectos beneficiosos en el manejo de la DMAE. En esta revisión se recogen los efectos de los ácidos grasos de la dieta poliinsaturados omega-3, monoinsaturados y saturados, y de las lipoproteínas en la DMAE. La literatura es consistente en el papel beneficioso de los ácidos grasos polinsaturados omega-3 de cadena larga, mientras que se muestra ambigua con los efectos de los ácidos grasos monoinsaturados y saturados de la dieta, respecto al posible papel protector de los ácidos grasos monoinsaturados como al posible efecto adverso de los ácidos grasos saturados en la DMAE. Además algunos mecanismos patológicos que asocian las lipoproteínas con la DMAE son los mismos observados previamente en las enfermedades cardiovasculares. Hacen falta estudios nutrigenómicos a corto y largo plazo para establecer el papel y la importancia de los ácidos grasos de la dieta, y las lipoproteínas en la aparición y progresión de la DMAE.PALABRAS CLAVE: Aceite de oliva; Ácidos grasos; Degeneración macular asociada a la edad; Grasas de la dieta; Lipoproteínas; Retina ORCID ID: Montserrat-de la Paz S http://orcid.org/0000-0001-5400-3192, Naranjo MC http://orcid.org/0000-0002-1516-8098, Bermúdez B http://orcid.org/0000-0002-7429-6567, López S http://orcid.org/0000-0001-5952-3568, Abia R http://orcid.org/0000-0003-2741-189...

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Oral Docosahexaenoic Acid in the Prevention of Exudative Age-Related Macular Degeneration

Cited by 129 publications

References 40 publications

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration

Dietary fatty acids and lipoproteins on progression of age-related macular degeneration

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