Oral Dosages Form: Medicine Containing Chewimg Gum: A Review

Rajesh, A.; Patel, Shreya; Sangeeta, Asija

doi:10.22270/jddt.v2i6.333

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…[ 23 ] The medicinal potentials of chewing gum are easy administration,[ 24 ] low overdosing risk, protection of drugs not to expose to enzymes, and acids of GI tract and fewer side effects. [ 25 26 ] They can be beneficial in people with xerostomia or people who have difficulties in swallowing tablets or capsules. [ 24 27 28 ] All types of chewing gums elevate blood flow to the brain through chewing and lead to stimulate alertness and improve cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Design, formulation, and evaluation of ginger medicated chewing gum

2016

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Background:Various ginger compounds improve gastrointestinal problems and motion sickness. The main effects of ginger allocate to some phenolics such as gingerols and shogaols that act as their active agents. Chewing gums are among convenient dosage forms which patients prefer due to their advantages. Hence, this study tried to design, formulate, and evaluate ginger chewing gum of favorable taste and texture to avoid motion sickness and have gastro-protective and anti-oxidant effect.Materials and Methods:Dried ginger rhizomes were percolated to extract ginger compounds. Total phenolics were measured in 70% hydro-alcoholic extract of ginger by gallic and tannic acid standards using Folin–Ciocalteu’s reagent. Chewing gums containing 50 mg of concentrated extract were prepared. Content uniformity, weight variation, release pattern, organoleptic, and mechanical properties were evaluated.Results:Phenolic content was measured 61.50 ± 5.27 mg/g and 76.75 ± 5.45 mg/g of concentrated extract as gallic acid and tannic acid equivalents, respectively. Release pattern of formulations with different gum bases and sweeteners demonstrated almost 100% release of drug. Evaluation of organoleptic properties was on 10 healthy volunteers and later prepared formulations exhibited better characteristics. Formulations without any flavorants have higher acceptability. Evaluation of mechanical properties showed higher stiffness of F15.Conclusion:Ginger chewing gum comprises admissible properties to be used as a modern drug delivery system due to its advantageous results in motion sickness. It passed all the specified tests for an acceptable chewing gum. Thus, it may be successfully produced to help GI problems.

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Section: Introductionmentioning

confidence: 99%

Design, formulation, and evaluation of ginger medicated chewing gum

2016

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A Review on Colon Targeted Drug Delivery System

Srujana¹,

Hemalatha²,

Padmalatha³

2023

AJPT

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Colon-specific drug delivery systems (CDDS) are advantageous for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. Colon targeted drug delivery system can be utilized to deliver protein and peptide drugs as they that are known to degrade in the extreme gastric pH. These approaches involve the use of formulation components that interact with one or more aspects of gastrointestinal (GI) physiology, such as the variation in the pH along the GI tract, the occurrence of colonic microflora, and enzymes, to attain colon targeting. This article highlights the advantages, limitations and factors influencing colon-specific drug delivery. Further, the review gives information of various conventional, as well as relatively newer formulation approaches presently being utilized for the improvement of CDDS.

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Formulation and Development of Medicated Chewing Gum Containing Ondansetron and Domperidone

S.,

A.,

et al. 2023

ijnrph

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This study aimed to determine the feasibility of combining ondansetron and domperidone into a single medicated gum. Molded Chewing Gum (MCG) was developed via direct compression. Our medicated chewing gum was designed with diabetics in mind, and Stevia was selected for the research because it does not increase blood glucose levels. Direct compression was used in the development of medicated gum. Each formulation's permissible flow characteristics and pre-compression parameters, including bulk density, tapered density, Carr's compressibility index, and Hausner ratio, were shown. After compression, it was determined that all of the parameters were within acceptable limits, including changes in weight, thickness, appearance, and in vitro drug release. There is no indication of drug-excipient interactions based on physical testing or TLC analysis. Two plasticizers only when comparing glycerol with coconut oil, the latter proved to be the superior plasticizer. Formulation F6 was chosen as the best option since all of the attributes fall within the expected range. The results of the F6 formulation were analyzed for their thickness, weight fluctuation, appearance, and in vitro drug release. Coconut oil shown to be the superior plasticizer for making MCG after testing and evaluation. Probably because the concentration is optimized for releasing the drug from the formulation, the fact that F6 includes 24 mg of coconut oil makes it a more effective formulation.

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Oral Dosages Form: Medicine Containing Chewimg Gum: A Review

Cited by 3 publications

References 10 publications

Design, formulation, and evaluation of ginger medicated chewing gum

Design, formulation, and evaluation of ginger medicated chewing gum

A Review on Colon Targeted Drug Delivery System

Formulation and Development of Medicated Chewing Gum Containing Ondansetron and Domperidone

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