Oral dyskinesia induced by fluoxetine therapy for infantile autism

Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice

“…In addition, cocaine-induced ataxia and PCs degeneration have been suggested as a consequence of the early-life modification to the cerebellar serotonergic system (Arpin-Bott et al, 2006; Summavielle et al, 2004). There is also growing evidence that early selective 5-HT reuptake inhibition may induce motor deficits later in life in both humans (Albertini et al, 2004; Casper et al, 2003) and rodents (Bairy et al, 2007; Lisboa et al, 2007; Maciag et al, 2006). Moreover, clinical studies demonstrate improved cerebellar ataxia in response to treatment with 5-HT precursor (Trouillas et al, 1988; Trouillas et al, 1995) as well as 5-HT1a agonist (Lou et al, 1995; Trouillas et al, 1997).…”

Extrapyramidal Reactions Associated With Serotonergic Antidepressants

“…Nine patient cases were identified in the previous review, 8 and 18 cases are summarized in our current review. [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] SSRI treatments were implicated in 72.2% of cases (citalopram/escitalopram, fluoxetine, paroxetine most frequently) with venlafaxine and duloxetine comprising the other cases. Monotherapy was present in 11.1% of cases, and treatments with D2 receptor antagonism were present in 27.8% of cases.…”

“…Our PubMed search identified 574 published articles, and of these, a total of 110 citations were selected for review; 86 (78%) citations, yielding 91 patient cases, were determined as relevant. There were 17 cases of akathisia, [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] 18 cases of dyskinesia, [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] 27 cases of dystonic reactions, 19 cases of parkinsonism, 27,77-94 and 10 "mixed" EPR cases. 19,[95][96][97][98][99][100][101][102][103] An overview of each case report by EPR category can be found in Table 1.…”

“…Albertini et al 37 reported the case (Naranjo total score = 5) of an oral dyskinesia in a 15-month-old male patient with a diagnosis of autism. The patient was admitted for impaired attention, poor responsiveness to environmental stimuli, poor emotional interaction with his mother, and stereotyped, repetitive mannerisms.…”

Informational Digest Bulletin from the San Raffaele Foundation and Tosinvest Sanità (No. 8). Child, Adult and Aging Developmental Centre Silvana Paolini Angelucci, a Modern Concept of Rehabilitation: Our Model in Cassino

“…Every child’s assessment and treatment scheduling is recorded on a comprehensive computerized database. This relational database (MAGIC I) contains demographic, clinical, diagnostic, and treatment (Albertini et al., 2004) information of all patients treated by the medical staff throughout a 7‐year period.…”