Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia)

Kaku, Yo; Shimamoto, Noriko; Matsunaga, Hiromi; Makiura, Munehiko; Fujisawa, Akihiro; Morita, Kazumasa

doi:10.1684/ejd.2010.1183

Cited by 10 publications

(5 citation statements)

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“…Three LP patients accompanied by thymoma are summarized in Table . In addition, we summarize 29 LP patients accompanied by thymoma previously reported in the English‐language published works (Table ) . The mean age of patients was 56.2 ± 11 years, and the male : female ratio was 1:1.…”

Section: Discussionmentioning

confidence: 95%

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Motegi

Uchiyama

Yamada

et al. 2015

The Journal of Dermatology

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Thymoma is recognized to be complicated with autoimmune diseases, such as myasthenia gravis, pemphigus vulgaris and bullous pemphigoid. Abnormal regulation of autoreactive lymphocytes may be involved in the pathogenesis of the autoimmune diseases. The association of thymoma and lichen planus (LP) is relatively rare. Among 50 patients with LP, we identified three patients with LP accompanied by thymoma (6%; 3/50) in our department from 2004 to 2014. This is the first report identifying the frequency of thymoma accompanied by LP among patients with LP. We herein report three cases of LP accompanied by thymoma along with clinical and histological features. In addition, we summarize 29 LP patients accompanied by thymoma previously reported in the English-language published works. Regarding the complications, hypogammaglobulinemia accompanied 58.6% (17/29) of patients diagnosed with Good's syndrome. Alopecia was present in 13.8% (4/29) of patients, and myasthenia gravis was present in 17.2% (5/29) of patients with LP and thymoma. Among the 27 patients with thymectomy, only 25.9% (7/27) experienced the improvement of LP, suggesting that thymectomy may not be effective for the lesions of LP. Treatment-resistant LP was reported in 54.2% (13/24) of patients. In all our cases, oral lesions were intractable to treatment with oral predonisone and topical steroids and/or tacrolimus. It is important for dermatologists to recognize the clinical characteristics of the patients with both LP and thymoma.

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Section: Discussionmentioning

confidence: 95%

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Motegi

Uchiyama

Yamada

et al. 2015

The Journal of Dermatology

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“…Lichen planus may be induced by neoplasia; paraneoplastic LP, and a cell-mediated immune reaction possibly backs this association. It was reported with thymoma, autoimmune diseases and Castleman's tumor [14][15][16]. After tumor resection LP lesions regressed and melanosed.…”

Section: Discussionmentioning

confidence: 98%

Post Radiotherapy “Isolated LP of the Lips” in a Non-Hodgkin Lymphoma Patient: A Possible Relation

Shelleh¹,

Hateeti²,

Fahhad³

et al. 2012

JCDSA

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We report upon a case of 62 years old Saudi male with non-Hodgkin lymphoma who developed lichen planus (LP) on the inner aspect of the upper lip six months after finishing radiotherapy. The diagnosis of LP was confirmed by histopathology. Literature review reveals few countable similar reports of “post radiotherapyoral LP (OLP)”. However, the isolated location of lichen planus on the upper lip per se in this case merits reporting being exceptional and reported before as isolated lichen planus of the lips (ILPL). We assume, after screening literature, that this is the first report of post radiotherapy ILPL in Arabian Gulf countries, though it may be underestimated and underreported. The etiological relation between radiotherapy and LP is discussed

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“…Lichen planus has frequently been documented to be associated with GS [ 11 – 14 ]. In this study, case 4 presented with recurrent oral lichen planus for unknown reasons.…”

Section: Discussionmentioning

confidence: 99%

Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

Zhang

Chen

et al. 2021

BMC Immunol

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Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed. Methods We used the hospital information system to retrospectively screen thymoma and hypogammaglobulinemia patients at the First Affiliated Hospital of Wenzhou Medical University from Apr 2012 to Apr 2020. The clinical, laboratory, treatment, and outcome data for these patients were collected and analyzed. Results Among the 181 screened thymoma patients, 5 thymoma patients with hypogammaglobulinemia were identified; 3 patients had confirmed diagnoses of GS, and the other 2 did not have a diagnosis of GS recorded in the hospital information system. A retrospective review of the clinical characteristics, laboratory results, and follow-up data for these 2 undiagnosed patients confirmed the diagnosis of GS. All 5 GS patients presented with pneumonia, 2 patients presented with recurrent skin abscesses, 2 patients presented with recurrent cough and expectoration, 1 patient presented with recurrent oral lichen planus and diarrhea, and 1 patient presented with tuberculosis and granulomatous epididymitis. In the years after the diagnosis of hypogammaglobulinemia with mild symptoms, all 5 patients had received irregular intravenous immunoglobulin (IVIG) treatment. As the course of the disease progressed, the clinical symptoms of all patients worsened, but the symptoms were partly resolved with IVIG in these patients. However, 4 patients died due to comorbidities. Conclusion GS should be investigated as a possible diagnosis in thymoma patients who present with hypogammaglobulinemia, especially those with recurrent opportunistic infections, recurrent skin abscesses, chronic diarrhea, or recurrent lichen planus.

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Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia)

Cited by 10 publications

References 0 publications

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Post Radiotherapy “Isolated LP of the Lips” in a Non-Hodgkin Lymphoma Patient: A Possible Relation

Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

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