Oral erythema multiforme: trends and clinical findings of a large retrospective European case series

Celentano, Antonio; Țovaru, Șerban; Yap, Tami; Adamo, Daniela; Aria, Massimo; Mignogna, Michele Davide

doi:10.1016/j.oooo.2015.08.010

Cited by 49 publications

(42 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Erythema multiforme (EM) is an acute mucocutaneous disease with classic target-like skin lesions that has been postulated as a type IV hypersensitivity reaction to various causative factors, with herpes simplex virus being the most common (3,10). Cytotoxic intra-and subepithelial damage follows, possibly due to non-self antigens on keratinocytes.…”

Section: Erythema Multiforme Stevens-johnson Syndrome and Toxic Epimentioning

confidence: 99%

“…EM can be subdivided into EM major and minor, with differences in mucosal involvement and clinical course (1,22). Although EM is largely self-limiting within a few weeks, a recurrent form of the disease also exists, with documented association with herpes simplex virus between 61 and 100% (10).…”

Section: Erythema Multiforme Stevens-johnson Syndrome and Toxic Epimentioning

confidence: 99%

“…However, the mucosal surfaces in EM are only slightly affected; in fact, among them the oral cavity most commonly undergoes changes (3,23). Broadly speaking, erythema and vesicles leaving painful pseudomembrane-covered ulcerations or necrotic mucosa can be found, particularly on the buccal and labial mucosa as well as the vermilion border (1,3,10,21,23). In addition, bloodstained crusts on the lips with subsequent speech and feeding problems are another notable manifestation (1,3,23).…”

Section: Erythema Multiforme Stevens-johnson Syndrome and Toxic Epimentioning

confidence: 99%

See 2 more Smart Citations

Oral manifestations of autoinflammatory and autoimmune diseases

Baglama

Trčko

Rebol³

et al. 2018

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

View full text Add to dashboard Cite

Section: Erythema Multiforme Stevens-johnson Syndrome and Toxic Epimentioning

confidence: 99%

Section: Erythema Multiforme Stevens-johnson Syndrome and Toxic Epimentioning

confidence: 99%

Section: Erythema Multiforme Stevens-johnson Syndrome and Toxic Epimentioning

confidence: 99%

See 1 more Smart Citation

Oral manifestations of autoinflammatory and autoimmune diseases

Baglama

Trčko

Rebol³

et al. 2018

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

View full text Add to dashboard Cite

“…The authors are very appreciative of comments presented by Professor Brown regarding our recent publication, 1 which highlighted the applicability of diagnostic criteria proposed by several authors in the last two decades. [2][3][4][5][6][7] We agree that future studies should consider the use of these presently well-established diagnostic criteria differentiating between erythema multiforme minor (EMm), erythema multiforme major (EMM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN).…”

mentioning

confidence: 83%

Oral erythema multiforme: trends and clinical findings of a large retrospective: European case series

Brown

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

al. 1 are to be congratulated on their recent publication. This excellent addition to the literature reports a retrospective case series of 60 oral erythema multiforme (EM) patients. However, presently, diagnostic criteria that distinguish between EM major (EMM), EM minor (EMm), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are available. Celentano et al. 1 have combined all of these diagnostic entities within the category of EM. This grouping is certainly appropriate, since the study patient population was initiated in 1982, when all such diagnoses would have been described within the category of EM. The authors commented that diagnostic criteria between EMM, EMm, SJS, and TEN presently are not universally accepted. However, a case can be made that such diagnostic criteria are presently relatively well established, although not universally accepted. 1-7 In 2005, Williams and Conklin 2 summarized the dermatologic diagnostic standards for EM, SJS, and TEN, as reported by Bastuji-Garin et al., 3 Assier et al., 4 and Auquier-Dunant et al., 5 and Cote et al. 6 These standards describe EM, SJS, and TEN as separate diagnostic entities with relatively well-defined diagnostic characteristics. Furthermore, Ayangco and Rogers 7 defined the similarities and differences between EMm and EMM. Hopefully in the near future, the oral medicine and oral and maxillofacial pathology communities will undertake confirmation of universally accepted diagnostic standards for EMM, EMm, SJS, and TEN, possibly at the next World Workshop of Oral Medicine.

show abstract

“…The prognosis of PNP remains poor, with mortality rates reaching 90% (Yong and Tey, ). – Erythema multiforme (EM) and Stevens‐Johnson syndrome (SJS). EM and SJS are two acute immune‐mediated disorders that can be triggered by numerous factors (Celentano et al, ). The skin and mucous membranes can be affected through a type 4 cytotoxic reaction, mediated by T lymphocytes and triggered by numerous factors.…”

Section: Desmosome Diseasesmentioning

confidence: 99%

Pathophysiology of the Desmo-Adhesome

et al. 2016

Self Cite

View full text Add to dashboard Cite

Advances in our understanding of desmosomal diseases have provided a clear demonstration of the key role played by desmosomes in tissue and organ physiology, highlighting the importance of their dynamic and finely regulated structure. In this context, non-desmosomal regulatory molecules have acquired increasing relevance in the study of this organelle resulting in extending the desmosomal interactome, named the "desmo-adhesome." Spatiotemporal changes in the expression and regulation of the desmo-adhesome underlie a number of genetic, infectious, autoimmune, and malignant conditions. The aim of the present article was to examine the structural and functional relationship of the desmosome, by providing a comprehensive, yet focused overview of the constituents targeted in human disease. The inclusion of the novel regulatory network in the desmo-adhesome pathophysiology opens new avenues to a deeper understanding of desmosomal diseases, potentially unveiling pathogenic mechanisms waiting to be explored. J. Cell. Physiol. 232: 496-505, 2017. © 2016 Wiley Periodicals, Inc.

show abstract

Oral erythema multiforme: trends and clinical findings of a large retrospective European case series

Cited by 49 publications

References 58 publications

Oral manifestations of autoinflammatory and autoimmune diseases

Oral manifestations of autoinflammatory and autoimmune diseases

Oral erythema multiforme: trends and clinical findings of a large retrospective: European case series

Pathophysiology of the Desmo-Adhesome

Contact Info

Product

Resources

About