Oral exposure to culture material extract containing fumonisins predisposes swine to the development of pneumonitis caused by Pasteurella multocida

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

“…Mononuclear and neutrophils infiltration in the interstitium and alveolar or bronchial lumina in the present experiment were mainly observed in infected animals compromised by FB 1 , which is in agreement with pathomorphological findings reported by Halloy et al (2005).…”

“…Histopathological damages in P. multocida infected pigs were similar, but less expressed than those described by Halloy et al (2005), who observed inflammatory mononuclear proliferation in the interstitium of lung. Mononuclear and neutrophils infiltration in the interstitium and alveolar or bronchial lumina in the present experiment were mainly observed in infected animals compromised by FB 1 , which is in agreement with pathomorphological findings reported by Halloy et al (2005).…”

“…This circumstance is considered to be a possible reason for the increased susceptibility to P. multocida infection in swine (Halloy et al, 2005) as seen in the present study. It was also supposed, that the increased susceptibility of porcine pulmonary capillary endothelium to FB 1 (Gumprecht et al, 2001) may also contribute to the increased susceptibility to infectious and/or inflammatory diseases (Halloy et al, 2005), which was supported in the present study. Some other studies have also confirmed the pro-inflammatory effects of FB 1 and contributed significantly to the explanation of these effects via some investigations on the cytokine profile of FB 1 exposed pigs (Taranu et al, 2005).…”

“…In this regard, Oswald and collaborators observed a significant increase of intestinal colonization of pathogenic Escherichia coli in FB 1 -treated pigs (Oswald et al, 2003). On the other hand, a heavy progression of Pasteurella multocida (Halloy et al, 2005) or porcine reproductive and respiratory syndrome (PRRS) virus infections in swine (Ramos et al, 2010) were seen when the same animals were compromised by feed exposure to FB 1 . There are also some recent reports about aggravations of pathological infections in pigs, when fed on FB1 contaminated diet (Pósa et al, 2011(Pósa et al, , 2013.…”

“…Nevertheless, the data available about the possible interaction between FB 1 and some frequent infectious pathogens in pigs can be evaluated as insuficient and scarce. As FB1 is a frequent contaminant of pigs' diet, and P. multocida is the most frequent secondary pathogen which can generate a respiratory disorder in predisposed or immunocompromised pigs (Halloy et al, 2005), such studies could have significant scientific and/or practical importance. In this regard, the data on the predisposing effect of FB 1 on the appearance and/or progression of the lesions provoked by toxigenic strain of P. multocida, serotype A and the interaction between the toxin and the bacterium are scarce (Halloy et al, 2005), independently of the circumstance that both agents (toxic and infectious) have the same target organ localization (lung), and the same can be encountered simultaneously in the pig production farms.…”