Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet

Anatriello, Elen; Cunha, Mariana Gisely Amarante Teixeira da; Nogueira, Jeane de Souza; Carvalho, José A.M.; Sá, Ana Karolina; Miranda, Munique; Hc, Castro-Faria-Neto; Keller, Alexandre C.; Aimbire, Flávio

doi:10.1016/j.cellimm.2019.103928

Cited by 35 publications

(23 citation statements)

References 51 publications

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“…Recently, a systematic review conducted by Zimmermann showed that a lower relative abundance of Lactobacillaceae in the intestinal microbiota in the first month of life was associated with the development of allergic sensitization [32]. Studies have shown that probiotics may be adjuvants in preventing atopic disease, such as dermatitis [33,34] and asthma [35,36]. However, many conflicting studies exist.…”

Section: Discussionmentioning

confidence: 99%

Comparing the nasal bacterial microbiome diversity of allergic rhinitis, chronic rhinosinusitis and control subjects

Gan

Yang

Meng

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose Until now, the microbiome of the nasal cavity and its contribution to nasal mucosal disease has remained poorly understood. The advent of cultivation-free molecular methods makes it possible to characterize the total microbiome of the nasal cavity. We sought to assess the microbial diversity and composition of the middle meatus in allergic rhinitis (AR) patients, chronic rhinosinusitis patients without polyps (CRSsNP) and a control population to determine the microbiota associated with the pathogenesis of AR and CRSsNP. Methods Microbial characterization was determined using 16S rRNA gene sequencing of 122 nasal swabs collected from patients with AR (n = 52) and CRSsNP (n = 37), and from healthy controls (n = 33). Results There was no difference in nasal microbiome richness and diversity among the three groups, and the dominant phyla were similar among three groups including Firmicutes, Proteobacteria, Actinobacteria and Bacteroidetes. However, Spirochaetae abundance was significantly higher in AR than in the control group after FDR correction (FDR p = 0.021). At the genus level, although there was no statistical significance after FDR correction, there was a trend that Pseudomonas and Peptostreptococcaceae abundance were higher in AR than in controls (p = 0.005, p = 0.005) and CRSsNP (p = 0.023, p = 0.034); Lactobacillus abundance was lower in AR than in controls (p = 0.021); Moraxella abundance was lower in CRSsNP than in controls (p = 0.006); Haemophilus abundance was higher in CRSsNP than in AR (p = 0.003) but lower in AR than in controls (p = 0.018). Conclusion These results suggested that microbial dysbiosis may play a role in the pathogenesis of heterogeneous nasal mucosal inflammation.

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Section: Discussionmentioning

confidence: 99%

Comparing the nasal bacterial microbiome diversity of allergic rhinitis, chronic rhinosinusitis and control subjects

Gan

Yang

Meng

et al. 2020

Eur Arch Otorhinolaryngol

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“…Therefore, probiotic use improves the body’s defenses by triggering an immune response, according to the pathological state, and promoting a balance between pro- and anti-inflammatory cytokines that are secreted by activated immune cells. Probiotics hence act as a non-specific adjuvant to the innate immune response [ 50 ]. There is evidence that probiotics promote the production of some cytokines, including IL-10, transforming growth factor (TGF)-β, IL-12, and INF-γ, which regulate the immune response and reduce allergic inflammation [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review

López-Santamarina

Gonzalez

Lamas

et al. 2021

Foods

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Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and for this reason, alternatives for the treatment of allergic diseases or reduction in their symptoms are being sought. The main objective of this study was to compile the studies carried out on probiotics as a possible therapy for allergies. The most studied allergies on which probiotics have been shown to have a beneficial effect are rhinitis, asthma, and atopic dermatitis. Most studies have studied the administration of Lactobacillus and Bifidobacterium spp. in children and have shown beneficial effects, such as a reduction in hyperreactivity and inflammation caused by allergens and a decrease in cytokine release, among other beneficial effects. In the case of children, no clear beneficial effects were found in several studies, and the potential risk from the use of some opportunistic bacteria, such as probiotics, seems controversial. In the studies that reported beneficial results, these effects were found to make allergy symptoms less aggressive, thus reducing morbidity in allergy sufferers. The different effects of the same probiotic bacteria on different patients seem to reinforce the idea that the efficacy of probiotics is dependent on the microbial species or strain, its derived metabolites and byproducts, and the gut microbiota eubiosis of the patient. This study is relevant in the context of allergic diseases, as it provides a broader understanding of new alternatives for the treatment of allergies, both in children, who are the main sufferers, and adults, showing that probiotics, in some cases, reduce the symptoms and severity of such diseases.

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“…During a co-localization study, the authors suggested that Th1 cells are responsible for the release of IFN-γ [ 58 ]. Study also showed that Lactobacillus bulgaricus N45.10 can modulate the immune responses in mice by preventing Th2 polarization and Th17 cells and increasing Th1 responses through the modulation of STAT6 and T-bet transcription factors [ 59 ]. In a chronic asthma mouse model, the administration of L. rhamnosus GG reduced the levels of Th2 cytokines and up-regulated Th1 cytokines [ 58 ].…”

Section: Ageing-related Decline In Immune System and The Role Of Lactobacillusmentioning

confidence: 99%

“…In a chronic asthma mouse model, the administration of L. rhamnosus GG reduced the levels of Th2 cytokines and up-regulated Th1 cytokines [ 58 ]. L. plantarum 06CC2 effectively induced the production of Th1 cytokines activating Th1 immune responses linked to intestinal immunity in normal mice [ 59 ]. Some probiotic strains have shown the ex-vivo up-regulation of immune responses of blood mononuclear cells by oral supplementation, suggesting the pro-Th1 immune stimulation.…”

Section: Ageing-related Decline In Immune System and The Role Of Lactobacillusmentioning

confidence: 99%

Microbiota Targeted Interventions of Probiotic Lactobacillus as an Anti-Ageing Approach: A Review

et al. 2021

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With the implementation of modern scientific protocols, the average human lifespan has significantly improved, but age-related problems remain a challenge. With the advent of ageing, there are alterations in gut microbiota and gut barrier functions, weak immune responses, increased oxidative stress, and other age-related disorders. This review has highlighted and discussed the current understanding on the significance of gut microbiota dysbiosis and ageing and its inherent effects against age-related oxidative stress as well as on the gut health and gut-brain axis. Further, we have discussed the key mechanism of action of Lactobacillus strains in the longevity of life, alleviating gut dysbiosis, and improving oxidative stress and inflammation to provide an outline of the role of Lactobacillus strains in restoration of gut microbiota dysbiosis and alleviating certain conditions during ageing. Microbiota-targeted interventions of some characterized strains of probiotic Lactobacillus for the restoration of gut microbial community are considered as a potential approach to improve several neurological conditions. However, very limited human studies are available on this alarmed issue and recommend further studies to identify the unique Lactobacillus strains with potential anti-ageing properties and to discover its novel core microbiome-association, which will help to increase the therapeutic potential of probiotic Lactobacillus strains to ageing.

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Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet

Cited by 35 publications

References 51 publications

Comparing the nasal bacterial microbiome diversity of allergic rhinitis, chronic rhinosinusitis and control subjects

Comparing the nasal bacterial microbiome diversity of allergic rhinitis, chronic rhinosinusitis and control subjects

Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review

Microbiota Targeted Interventions of Probiotic Lactobacillus as an Anti-Ageing Approach: A Review

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