Oral findings in children and adolescents with Prader-Willi syndrome

Olczak‐Kowalczyk, Dorota; Korporowicz, Emil; Gozdowski, Dariusz; Lecka-Ambroziak, Agnieszka; Szalecki, Mieczysław

doi:10.1007/s00784-018-2559-y

Cited by 16 publications

(11 citation statements)

References 41 publications

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“…Olczak-Kowalczyk D et al (2019) showed that the mean gingival index values in PWS patients with mixed dentition, were significantly higher than in the control group, but the mean plaque index values were not [36]. In our sample there were more cases of gingivitis in patients with PWS than in their healthy peers, but the differences were not statistically significant.…”

Section: Discussioncontrasting

confidence: 59%

“…Olczak-Kowalczyk D et al also confirmed worse physical and chemical parameters of saliva in subjects with PWS compared to the control group. They found a negative correlation between the age of PWS patients and watery consistency of saliva, and suggested that salivary viscosity may increase with age [36]. As we mentioned above, the difficulty of obtaining saliva in some non-collaborative patients meant that our study lacked the statistical power needed to carry out an in-depth analysis of this correlation between age and salivary viscosity.…”

Section: Discussionmentioning

confidence: 89%

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Oral disorders in children with Prader-Willi syndrome: a case control study

Munné-Miralvés

Brunet‐Llobet

Cahuana-Cárdenas

et al. 2020

Orphanet J Rare Dis

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Introduction: Prader-Willi Syndrome (PWS) is a genetic disorder caused by the lack of expression of certain paternal genes located on chromosome 15q11-q13. This anomaly causes cognitive, neurological and endocrine abnormalities, among which one of the most important is hyperphagia. The aim of this study was to assess the oral health of children with PWA and to establish preventive criteria. Results: Thirty patients with PWS (mean age 10.2 years) and 30 age-and gender-matched controls were included in the study. Twenty-six patients with PWS(86.6%) followed dietary treatment prescribed by their endocrinologist. Individuals with PWS had a mean caries index of 53.3% and Decayed Missing Filled teeth (DMFT) index 2.5, and 53.3% had gingivitis, in the control group the respective figures were 43.3%, 0.93, and 60%. Only the DMFT index (p 0.017) presented significant differences. Regarding stimulated salivary secretion, patients with PWS presented a mean of 0.475 ml/min with a pH of 6.15, while controls presented a mean of 0.848 ml/min with a pH of 7.53; the differences between the groups were statistically significant in both cases (p 0.032 and p 0.0001 respectively). The population with PWS presented a higher plaque index (> 2) than their healthy peers, but the differences were not significant. Conclusion: Pediatric patients with Prader-Willi syndrome have an increased risk of caries and gingivitis. The children with this syndrome have a decreased salivary flow and a more acidic salivary pH. In these patients, dental care is an essential part of their multidisciplinary medical treatment.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 89%

Oral disorders in children with Prader-Willi syndrome: a case control study

Munné-Miralvés

Brunet‐Llobet

Cahuana-Cárdenas

et al. 2020

Orphanet J Rare Dis

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“…A variety of oral diseases are found in patients with PWS (Table 2) such as caries,1,17,21,25–31 hypoplastic enamel,1,17,25,28,31 viscous saliva,1,17,21,25,30–32 periodontal disease,25–28 tooth wear,1,26,27,31,32 dental erosion,33 rampant caries,1,29,31 oral microsomia,25,31 dental malocclusion,1,17,21,26–29 candidiasis,25,27 erythematous lesions of the oral mucosa,27 increased biofilm accumulation,1,21,25,31,32 gingivitis,1,25,27,31,32 angular cheilitis, dry mouth,28 demineralization,21,25,31 dentoalveolar abscess,29,31 hypotonic tongue,21,31 mouth breathing,21,31,32 root stumps30 and a delay in tooth eruption 28Table 2Oral manifestation, referenceOral manifestation Júnior et al, 2005Scardina; Fuca; Messina, 2007Bailleuil-Forestier et al, 2008Yanagita et al, 2011Witt et al, 2011Setti et al, 2012Gardens et al, 2014Song et al, 2015Hurren, Flack, 2016 (review)Tayal et al, 2016Roman-Torres et al, 2017Olczak-Kowalczyk et al, 2018*…”

Section: Introductionmentioning

confidence: 99%

“…A recent study observed that gingivitis and dental wear in children and adolescents with PWS presented with an etiology from changes in saliva. More viscosity, minor salivary secretion, and mouth breathing are components that predispose patients to the risks of plaque inducing gingivitis and tooth wear 32. Abnormal salivary fluid influences enamel loss, caries, and dental erosion.…”

Section: Introductionmentioning

confidence: 99%

“…The features of saliva features also influence and makes it difficult to clean the teeth. Viscosity and poor salivary flow are factors for dental plaque accumulation and gingivitis 32. Normal salivation has been shown to be crucial in protecting teeth against the acidic factors that initiate dental erosion through its buffering capacity, clearance by swallowing, pellicle formation, and remineralization of demineralized enamel 37…”

Section: Introductionmentioning

confidence: 99%

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<p>Oral health in patients with Prader-Willi syndrome: current perspectives</p>

Bantim¹,

Kussaba²,

Carvalho³

et al. 2019

CCIDE

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Prader-Willi syndrome (PWS) is a rare complex multisystem disorder and presents several aspects related to dentistry. The purpose of this review is to present current perspectives about oral health in patients with PWS. Delay development, hyperphagia, foamy and highly viscous saliva raise the risk of caries and contribute to tooth wear. Cariogenic foods uncontrolled consumption allows to obesity and dental problems progress worsening systemic disorders. These factors can be controlled. The success in follow-ups with caries free and oral health controlled demonstrate the importance of multidisciplinary team intervention corroborated by support at home from birth to adulthood. Thereby, current perspective on the disease is that there is possibility of proper maintenance of oral health in PWS patients. Guided care interferes positively with the overall well-being and quality of life of the individual with PWS and their family. A multidisciplinary team with a focus on teaching patients and family members will help minimize eventual problems.

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