Oral focal mucinosis of posterior maxilla

Kumar, Nilesh; Kothi, Huzaifa S; Patil, Rahul; Pramod, R

doi:10.4103/jomfp.jomfp_242_15

Cited by 9 publications

(11 citation statements)

References 5 publications

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“…However, in Case 1, resorption of the jaw bone, which is unusual for OFM, was also seen, which made an accurate clinical diagnosis difficult. There was only one case other than our case report that reported bone resorption in the radiological findings [23]. Even though radiographic findings have typically shown the mandibular cases of odontogenic myxoma to be multilocular [24], in these cases, the masses were unilocular on radiography; we presume that bone absorption was caused by compression with increasing size of the lesion.…”

Section: Discussionmentioning

confidence: 61%

“…While the pathophysiology of OFM is not clearly understood, it is characterized by the local deposition of mucin in connective tissue in which there has been mucoid degeneration [1]. To the best of our knowledge, there have been 65 reported cases of this disease in the English literature [1–23] (Table 1). The age of the patients ranged from 2 to 68 years, with a mean age of 38.4 years.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical diagnosis of OFM is particularly difficult, and the diagnoses in previous reports have included fibroma (32.8%), epulis (10.4%), papilloma (3.0%), mucocele (3.0%), benign tumor (1.5%), periodontal abscess (1.5%), and giant cell granuloma (1.5%), as well as pleomorphic adenomas in cases of lesions of palatal origin [23] (Table 1). A large number of cases (44.8%) were unidentified, with unrecorded clinical diagnoses at the first medical visit.…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis and treatment of oral focal mucinosis: a case series

et al. 2019

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Background Oral focal mucinosis, the oral counterpart of cutaneous focal mucinosis, is a rare disease. As it has no characteristic clinical or radiological features, diagnosis is established by histopathological and immunohistological examination. We present three cases of oral focal mucinosis occurring in the retromolar (which is extremely rare) and gingival regions. Case presentation Case 1 involved a 26-year-old Japanese man with radiolucency in the right retromolar region on panoramic radiograph and computed tomography; no obvious protrusion was observed in the region. This finding was clinically diagnosed as a tumor of the retromolar region. Case 2 involved a 60-year-old Japanese woman. A tumor-like mass of tissue was identified on the buccal gingiva at the maxillary right canine and first premolar region. The lesion measured 7 × 6 mm and exhibited elastic hardness and healthy-colored mucosa. The lesion was diagnosed as an epulis. Case 3 involved a 47-year-old Japanese woman. A tumor-like mass of tissue was identified on the buccal gingiva at the maxillary right canine and first premolar region. The lesion measured 10 × 10 mm and exhibited elastic hardness and redness of the surface mucosa. This lesion was also diagnosed as an epulis. Resection was performed in all three cases, and the lesions were histopathologically diagnosed as oral focal mucinosis. Postoperative courses were uneventful and, thus far, there have been no recurrences. Conclusions Although it is difficult to diagnose oral focal mucinosis based on clinical symptoms and imaging findings, the disease should be considered a possibility when diagnosing benign oral tumors. We believe that an emphasis on histopathologic study is essential to confirm the clinical suspicion.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnosis and treatment of oral focal mucinosis: a case series

et al. 2019

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“…Of these, 60 duplicates were eliminated, and the criteria for inclusion and exclusion were applied to 196 references. A total of 36 articles reporting 100 cases of OFM were selected 1‐5,7‐37 . Most papers were single case reports or case series that originated from 13 different countries: Canada (one case), the United States (34 cases), Venezuela (one case), Brazil (18 cases), Italy (three cases), Sweden (one case), Turkey (one case), Iran (one case), Israel (one case), Japan (five cases), South Korea (one case), India (16 cases), and Australia (16 cases).…”

Section: Resultsmentioning

confidence: 99%

Oral focal mucinosis: A multi‐institutional study and literature review

et al. 2020

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Background: Oral focal mucinosis (OFM) is a rare benign condition of unknown etiology, considered the oral counterpart of cutaneous focal mucinosis. We report the clinicopathologic features of 21 cases of OFM in conjunction with a review of the literature. Methods: Clinical data were collected from the records of five oral and maxillofacial pathology services. All cases were evaluated by hematoxylin and eosin staining, histochemistry, and immunohistochemistry (vimentin, S-100, α-SMA, CD34, and mast cell). Results: The series comprised 14 females (66.7%) and seven males (33.3%), with a mean age of 48.2 ± 20.7 years (range: 8-77 years) and a 2:1 female-to-male ratio. Most of the lesions affected the gingiva (n = 6, 28.6%) and presented clinically as asymptomatic sessile or pedunculated nodules with fibrous or hyperplasic appearance. All cases were negative for S-100 protein, CD34, and α-SMA and positive for Alcian blue staining. Conservative surgical excision was the treatment in all cases, and there was only one recurrence. Conclusion: OFM is a rare benign disorder that is often clinically misdiagnosed as reactive lesions or benign proliferative processes. Dermatologists and pathologists should consider OFM in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located in the gingiva. K E Y W O R D S connective tissue diseases, diagnosis, oral focal mucinosis, oral pathology 1 | INTRODUCTION Oral focal mucinosis (OFM) is considered to be the oral counterpart of cutaneous focal mucinosis (CFM) that likely develops due to an overproduction of hyaluronic acid by fibroblasts. 1-3 As a result, a well-demarcated myxomatous tissue positive for Alcian blue (pH 2.5) is observed microscopically; which may mimic other oral myxoid lesions, such as soft-tissue myxoma, fibrous hyperplasia with myxoid degeneration, nerve sheath myxoma (NSM), myxoid neurofibroma, and mucocele. 1

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“…Other staining methods used for histological assessment include Alcian blue and silver impregnated staining. 4 Management of the lesion is primarily by conservative surgical excision and recurrence is unlikely.…”

Section: Images In…mentioning

confidence: 99%