Oral gallic acid improve liver steatosis and metabolism modulating hepatic lipogenic markers in obese mice

Sousa, Jaciara Neves; Paraíso, Alanna Fernandes; Andrade, João Marcus Oliveira; Lelis, Deborah Farias; Santos, Emanuele; Lima, Juliana Pinto de; Monteiro-Júnior, Renato Sobral; D’Angelo, Marcos Flávio Silveira Vasconcelos; Paula, Alfredo Maurício Batista de; Guimarães, André Luiz Sena; Santos, Sérgio Henrique Sousa

doi:10.1016/j.exger.2020.110881

Cited by 43 publications

(12 citation statements)

References 44 publications

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“…For example, a study found that the treatment of caffeine could increase the level of MDA in the zebrafish brain (de Carvalho et al., 2019). Several studies showed that ellagic acid and gallic acid could ameliorate liver steatosis in mice (Sousa et al., 2020; Zhang et al., 2019).…”

Section: Resultsmentioning

confidence: 99%

Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high‐fat diet

Mao

Meng

et al. 2021

Food Science & Nutrition

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Nonalcoholic fatty liver disease (NAFLD) is considered as a severe threat to human health. It has been reported that tea has abundant bioactive compounds and beneficial effects. In our study, the effects of 12 tea extracts on NAFLD were assessed and compared at the dose of 200 mg/kg body weight in mice fed with a high‐fat diet (HFD) for 15 weeks. Enshi Yulu Tea, Fenghuang Narcissus Tea, and Yihong Tea showed strong effects in suppressing the accumulation of epididymal and perirenal adipose tissue as well as the increases of body weight and liver weight. The histopathological analysis revealed that hepatic steatosis and adipocyte hypertrophy induced by a HFD could be ameliorated by tea supplementation. In addition, Enshi Yulu Tea and Qing Brick Tea exerted more remarkable functions on decreasing the level of serum triglyceride and preventing hepatic fat accumulation, respectively. Furthermore, Fenghuang Narcissus Tea, Enshi Yulu Tea, and Qing Brick Tea could reverse the abnormal change in the levels of glutathione and superoxide dismutase. Moreover, 13 phytoconstituents were detected and quantified in these teas with high‐performance liquid chromatography (HPLC) method. The correlation analysis demonstrated that gallic acid might decrease MDA level, and the reduction of liver weight might be attributed to ellagic acid. However, it should be paid attention to some teas that showed hepatotoxicity with elevated levels of aspartate transaminase and alanine aminotransferase. Several teas showed strong effects in the prevention of NAFLD, which could be developed into functional foods against NAFLD.

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Section: Resultsmentioning

confidence: 99%

Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high‐fat diet

Mao

Meng

et al. 2021

Food Science & Nutrition

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“…There are many scientific reports indicating the positive health influence of phenolic compounds isolated from selected edible or nonedible plants [ 30 , 31 ]. This potential is attributed to phenolics’ high antioxidant activity, the ability to restrain steatosis and the expression of lipogenic proteins, as well as improvement of glucose uptake and reduction of insulin resistance, among others [ 17 , 32 , 33 , 34 , 35 ]. On the other hand, there are few reports of the above-mentioned in vitro activities observed for plant preparations rich in phenolic compounds after the digestion process.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Simulated In Vitro Digestion on Biological Activity of Viburnum opulus Fruit Juices

et al. 2021

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In the present study, an in vitro digestion method has been used to assay the influence of the physiological conditions in the mouth, stomach, and intestine on the stability and activity in different cell models of the main phenolic compounds from Viburnum opulus fresh juice (FJ), phenolic-rich juice (PJ), and the bioavailable fractions (DFJ and DPJ). The data obtained indicate that the V. opulus samples achieved after in vitro digestion had an influence on cellular glucose and lipid metabolism. The bioavailable fraction of both digested juices stimulated glucose uptake and decreased lipid accumulation by L6 myoblasts and HepG2 hepatocytes. Both DFJ and DPJ reduced the secretion of inflammatory cytokines by 3T3-L1 adipocytes: interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Simultaneously, DFJ and DPJ enhanced oxidative stress in MIN6 cells and decreased glucose-stimulated insulin secretion (GSIS). UPLC–MS analysis revealed qualitative and quantitative changes in hydroxycinnamic acids. In particular, the content of chlorogenic acid decreased drastically; its content in the bioavailable fraction was almost 7 times and 30 times lower than in the FJ and PJ, respectively. Our results suggested that although the phenolic compounds of V. opulus juices undergo transformation during digestion, they are still potent antioxidant agents with biological activity.

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“…Gallic acid can also improve blood glucose levels, insulin levels, body weight, and hepatic steatosis. [119][120][121][122] In an in vitro study by Makihara et al, 123 gallic acid prevented and treated MS by upregulating adiponectin levels and regulating adipocyte differentiation. Previous in vitro and in vivo experiments fully demonstrated the beneficial effects of gallic acid in treating obesity, NAFLD, diabetes, DN and other diseases.…”

Section: Reviewmentioning

confidence: 99%

Natural polyphenols: a potential prevention and treatment strategy for metabolic syndrome

Wang

Meng

et al. 2022

Food Funct.

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Oral gallic acid improve liver steatosis and metabolism modulating hepatic lipogenic markers in obese mice

Cited by 43 publications

References 44 publications

Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high‐fat diet

Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high‐fat diet

The Effect of Simulated In Vitro Digestion on Biological Activity of Viburnum opulus Fruit Juices

Natural polyphenols: a potential prevention and treatment strategy for metabolic syndrome

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