Oral giant cell tumor or giant cell granuloma: How to know?

Hoarau, E.; Quilhot, P.; Baaroun, V.; Lescaille, G.; Campana, F.; Lan, R.; Rochefort, J.

doi:10.1016/j.heliyon.2023.e14087

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e14087

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Oral giant cell tumor or giant cell granuloma: How to know?

E. Hoarau

P. Quilhot

V. Baaroun

et al.

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Cited by 4 publications

References 44 publications

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Radiotherapy Combined With Zoledronic Acid for Fibrous Dysplasia With a Central Giant Cell Granuloma: A Case Report

Xu,

Gao,

Liu

et al. 2024

Head & Neck

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BackgroundGiant cell reparative granulomas are nonneoplastic, benign lesions that can expand and dissolve bone. Fibrous dysplasia is a benign condition in which normal bone tissue is replaced by abnormally proliferating immature reticular bone and fibrous tissue. The combination of giant cell reparative granuloma and fibrous dysplasia is extremely rare and can pose diagnostic and therapeutic challenges because of the complexity of clinical presentation.Case PresentationWe here present a patient who had a combination of fibrous dysplasia of bone and a giant cell reparative granuloma. An elderly male was admitted to the hospital with a blood‐streaked nasal discharge, blurry vision in his right eye, and an enlarged mass under the chin. A CT scan revealed that the lesion had infiltrated the head and face extensively, including the right maxillary sinus, sieve sinus, and the right nasal cavity, contraindicating surgery. The patient received a total dose of 30 Gy of 6 MV x‐ray radiotherapy delivered through helical tomotherapy over 15 sessions, with a single dose of 2 Gy being administered five times a week. Concurrently, The dose is 4 mg of zoledronic acid administered intravenously once every 21 days. After treatment, the patient's nasal congestion was significantly relieved, the vision of the right eye improved, and the mandibular lesion was significantly reduced.ConclusionsTreatment with radiotherapy combined with zoledronic acid for our patient's inoperable osteolytic giant cell reparative granuloma adjacent to vital nerves and blood vessels was extremely effective and safe. This case report provides a reference for the management of this rare combination.

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Radiotherapy Combined With Zoledronic Acid for Fibrous Dysplasia With a Central Giant Cell Granuloma: A Case Report

Xu,

Gao,

Liu

et al. 2024

Head & Neck

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Management of a rare mandibular giant cell tumor of bone by neoadjuvant denosumab therapy and surgery: A 4-year follow-up case report

Klienkoff,

Weingertner,

Geyer

et al. 2023

International Journal of Surgery Case Reports

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Peculiaridades Do Granuloma Periférico De Células Gigantes: Relato De Caso E Implicações Clínicas

Reginaldo,

Pillusky,

Escobar

et al. 2024

Rev. Foco

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O Granuloma Periférico de Células Gigantes (GPCG) é uma lesão benigna relativamente comum observada na cavidade oral, surgindo de uma resposta hiperplásica exuberante do tecido conjuntivo diante de fatores irritantes ou trauma local. Paciente sexo feminino, 52 anos, parda, procurou atendimento odontológico queixando-se de “lesão com sangramento e inchaço facial de rápida evolução”. Durante o exame físico, foi observado abaulamento no lado esquerdo da face e presença de uma massa exofídica pulsátil na gengiva vestibular do elemento 24 até a tuberosidade maxilar. A tomografia computadoriza revelou uma extensa lesão hipodensa envolvendo o seio maxilar, palato, cornetos nasais e assoalho da órbita. A biópsia incisional, combinada com exames bioquímicos, confirmou o diagnóstico de GPCG. A paciente foi encaminhada a um serviço hospitalar para a remoção da lesão. Posteriormente, foi necessária a reabilitação da função mastigatória, fonética e estética com uma prótese adaptada, devido à comunicação entre a cavidade oral e nasal. O GPCG pode atingir grandes dimensões, gerar comorbidades e impactos significativos na qualidade de vida do paciente, necessitando de reabilitação multidisciplinar.

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Oral giant cell tumor or giant cell granuloma: How to know?

Cited by 4 publications

References 44 publications

Radiotherapy Combined With Zoledronic Acid for Fibrous Dysplasia With a Central Giant Cell Granuloma: A Case Report

Radiotherapy Combined With Zoledronic Acid for Fibrous Dysplasia With a Central Giant Cell Granuloma: A Case Report

Management of a rare mandibular giant cell tumor of bone by neoadjuvant denosumab therapy and surgery: A 4-year follow-up case report

Peculiaridades Do Granuloma Periférico De Células Gigantes: Relato De Caso E Implicações Clínicas

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