Oral glucose effectiveness and metabolic risk in obese children and adolescents

Spreghini, Nicola; Cianfarani, Stefano; Spreghini, Maria Rita; Baratto, Claudia; Morino, Giuseppe; Inzaghi, Elena; Convertino, Alessio; Fintini, Danilo; Manco, Melania

doi:10.1007/s00592-019-01303-y

Cited by 14 publications

(9 citation statements)

References 33 publications

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“…Therefore, the obtained results fully correspond to the literature data about lipid profile in patients with obesity and indicate in favor of proatherogenic potential, more pronounced on the background of MS [16][17][18]. In particular MS is characterized by a li-pid triad, which is represented by high values of TG, LDL cholesterol and low values of HDL cholesterol, which increase the risk of cardiovascular diseases even in the absence of carbohydrate metabolism disorders and hypertension [19,20].…”

Section: Blood Lipid Spectrum In Adolescents With Obesity (M ± σ)supporting

confidence: 86%

Indicators of lipid metabolism disorders in the blood serum of adolescents with metabolic syndrome

Strashok¹,

Buznytska²,

Meshkova³

2020

Ukr.Biochem.J

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atherogenic dyslipidemia is one of the main and early indications of adolescents with metabolic syndrome. Because there is not enough information about the nature of dyslipidemia in adolescents and the possibilities of its correction and prevention, the study of this problem is relevant. The goal of the study was to estimate the indexes of lipid metabolism in blood serum of adolescents with metabolic syndrome. We examined 200 obese patients aged 14-18 years, who were divided into two groups with and without metabolic syndrome. The control group consisted of 30 adolescents of similar age with normal body weight. The lipid profile of blood was studied by standardized methods using semi-automatic photometer . The level of β-lipoproteins in blood serum was determined by the turbidimetric method. elevated levels of triglycerides, low and very low density lipoprotein cholesterol, β-lipoproteins and a tendency to decreased high density lipoprotein level cholesterol were found in the blood serum of adolescents with metabolic syndrome as the signs of atherogenic dyslipidemia. Reliable correlations both between the indexes of lipid profile and between atherogenic dyslipidemia indicators and anthropometric indexes were established, indicating an increased risk of lipid metabolic disturbances in individuals with abdominal obesity. k e y w o r d s: adolescents, metabolic syndrome, dyslipidemia.

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Section: Blood Lipid Spectrum In Adolescents With Obesity (M ± σ)supporting

confidence: 86%

Indicators of lipid metabolism disorders in the blood serum of adolescents with metabolic syndrome

Strashok¹,

Buznytska²,

Meshkova³

2020

Ukr.Biochem.J

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“…These results confirm the current ideas about obesity as a psychosomatic disease, in the origin of which both psychological and somatic factors play a role [16,17,18]. The psychological effects of childhood obesity on the patient and his or her family require screening for mental health and counseling if needed.…”

Section: Discussionsupporting

confidence: 86%

Nutrition Peculiarities of Ukrainian Adolescents With Metabolic Syndrome

2021

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The aim: To study the dietary peculiarities of Ukrainian adolescents with obesity and to identify the eating disorders on the background of metabolic syndrome. Materials and methods: A survey on the nutrition of Ukrainian adolescents was conducted at O. Yaremenko Ukrainian Institute for Social Research within the framework of the international project Health and Behavioral Orientations of Student Youth (HBSC), 2018. As a result, a sample of 200 adolescents with obesity (age 14-18 years: 100 boys and 100 girls) was formed, with the following examination by the Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine. Results: A survey conducted revealed the problem of irrational and unbalanced diet in Ukrainian adolescents. Thus, irregular and unbalanced diet naturally causes digestive disorders and contributes to the formation of comorbid pathologies such as obesity and metabolic syndrome. The general analysis of the DEBQ survey results revealed that patients with metabolic syndrome were twice as likely to have abnormalities in eating behavior (71.8 ± 3.7)% than in patients without them (39.4 ± 4.1)%, (φ < 0.05). Adolescents with obesity experienced significant zinc and magnesium deficiency in the body (φ < 0.05). Conclusions: Modification of eating behaviour through healthy balanced nutrition and psychological support is one of the most important tasks in the treatment of patients with obesity and metabolic syndrome.

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“…In summary, regular physical exercise emerges as a cornerstone as a preventive measure to improve host defense against influenza viral infection and other metabolic diseases in obese subjects (but not only). Furthermore, the increase in overweight and metabolic syndrome among adolescents in US [33,34] and other industrialized countries [35,36] constitutes an additional problem. In fact, being social distancing the only preventive measure that can be taken waiting for a vaccine against COVID-19, children and adolescents constitute a population where the actuation of social distancing is more difficult than in adults and where, apparently, there is a less symptomatic disease with a higher chance of having asymptomatic virus carriers.…”

Section: What Are the Lessons To Be Learned From Previous Influenza Vmentioning

confidence: 99%

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

2020

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Aims Analyze the relationship between obesity and influenza. Methods Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic. Results Waiting for the development of a vaccination against COVID-19, isolation of positive cases and social distancing are the primary interventions. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. Conclusions Due to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Oral glucose effectiveness and metabolic risk in obese children and adolescents

Cited by 14 publications

References 33 publications

Indicators of lipid metabolism disorders in the blood serum of adolescents with metabolic syndrome

Indicators of lipid metabolism disorders in the blood serum of adolescents with metabolic syndrome

Nutrition Peculiarities of Ukrainian Adolescents With Metabolic Syndrome

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

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